The resulting alienation of the child from the parent creates degrees of diminished relationship between the child and the alienated parent in a manner which can result in loss of affection and a reduction in quality of life for that parent, and may create dysfunctional
effects over time for the child.
Not exact matches
Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the
timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential
for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the
effect on aircraft demand and build rates of changing customer preferences
for business aircraft, including the
effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the
effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals
for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand
for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price
for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the
effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the
effect of changes in tax law, such as the
effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the
effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate
for our additional capital needs or
for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control
over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions
for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.
«Having spare
time and perceiving control
over how to spend that
time (i.e. discretionary
time) has been shown to have a strong and consistent
effect on life satisfaction and happiness, even controlling
for the actual amount of free
time one has.»
Over time, as people became more and more aware of the
effects commonly used products can have on the environment, plastic - happy clients who once cared mostly
for cost and convenience morphed into savvy customers with real concerns about the impact polyethylene and other petroleum - based products have on the ecosystem.
Fees are extremely important to take into consideration when evaluating options
for retirement, because the
effects are compounded
over a long
time horizon, and high fees and costs can cause serious harm to your retirement savings.
The series of studies tested the
effects of power hierarchies on team productivity by creating teams with either a mixed propensity towards leadership — in one case some participants were primed to feel powerful by thinking of a
time they wielded power
over others while others subjects were asked to envision a
time they were bossed around before joining the group — or teams made up entirely of hard charging leadership types or participants primed
for a meeker, go along, get along approach.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues
for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement
for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding
for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the
effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications
for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all,
for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products
over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from
time to
time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
What social influencer lists don't account
for is the cumulative
effect of influence a person achieves
over time and in the «real world».
Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation
over our business and the potential
effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required
for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer
time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger;
effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.
However, the
effects could actually become slightly bullish
over time as the recovery efforts pick up, and intriguingly, there is «potential
for some sustained US onshore production curtailments.»
The same
effect could have been achieved by temporary employment, as the Bible itself stipulates
for Israelites (Lev 25:39)» @Chad «LOL you have ZERO understanding of the practice at the
time,
over 30 % of the Roman population was slaves.
Either they necessitate a deceptive «God», e.g. creating starlight «in transit» which means that
for some light the star that supposedly sent said light would never have actually existed, or they would cause
effect that should be evident but are not, e.g. temporarily fast starlight would effectively cook many things, such as life on earth, if the required light (and attendant gamma radiation) were compressed into a significantly shorter
time frame (think of the radiation from the apparent 13 billion years of the universe arriving at the same
time, or even
over a 1000 years).
I personally think religion should not be a factor.No one should ask the candidates what their religious views are and they should never mention them.Their religious preferences have absolutely no
effect on what type of leader they will be.Unless they are some kind of a religious fanatic.I think it's
time for an atheist.There was not a Christian president
for over the first 50 years of our nations existence.And, I do not think there has been one since.If you look it up you will find not one of our founding fathers were Christian.Not even Jefferson.I know he wrote the Jefferson bible, but, that's just because he, like the other founding fathers, did not believe Jesus to be of divine decent.So, he kept his philosophy while removing all the mystical and dogmatic concepts.
I would say guiding forces
for me are not concretely one thing or another, but more of a culmination of many
effects and experiences
over time.
For our purposes, the medical and psychiatric therapies may be divided into three categories according to their purpose: (1) those therapies that aid in the physical rehabilitation of the person suffering from the effects of an acute binge and / or prolonged excessive drinking over many years; (2) those that help to keep the addictive cycle broken and thus maintain sobriety for sufficient time to allow other therapies to take effect; (3) those that aim at lessening the alcoholic's personality problems — both those that contributed to the causation of his addiction and those resulting from the interpersonal chaos of progressive alcoholi
For our purposes, the medical and psychiatric therapies may be divided into three categories according to their purpose: (1) those therapies that aid in the physical rehabilitation of the person suffering from the
effects of an acute binge and / or prolonged excessive drinking
over many years; (2) those that help to keep the addictive cycle broken and thus maintain sobriety
for sufficient time to allow other therapies to take effect; (3) those that aim at lessening the alcoholic's personality problems — both those that contributed to the causation of his addiction and those resulting from the interpersonal chaos of progressive alcoholi
for sufficient
time to allow other therapies to take
effect; (3) those that aim at lessening the alcoholic's personality problems — both those that contributed to the causation of his addiction and those resulting from the interpersonal chaos of progressive alcoholism.
«
Over time, the
effect on the reward centre in the brain is similar to what makes drug addicts go back
for another line of cocaine.»
There remains a need
for future research to particularly show the
effects of sustained or longer - term exposures to food advertising and to test whether the observed increases in intake after acute exposures are not later compensated
for and, therefore, could lead to weight gain
over time (54).
While toasting on the tawa, make sure you toast them
over low flame taking enough
time for the crispy and crunchy
effect and
for even browning of the bread slices.
And to be fair, that tactic has been a very useful one
for us in recent
times as shown to such devastating
effect when Manchester United came to the Emirates about a month ago and the game was
over after 20 minutes following a three goal blitz.
If that's had a similar
effect to when he did the Indy 500 and made you want to watch it
for the first
time, or if you're unsure
over exactly what the Daytona 24 Hours is, then this handy guide should tell you all you need to know.
You can perfect the technique
for some of these moves
over a period of
time but it will be fine to simply perform the movements as best as you can as it won't take you too long to master the moves and develop a 20 - 30 minute workout that should have a positive
effect on your body.
Walking in a hunched
over position
for long periods of
time can drastically
effect your posture which can lead to some serious back problems down the line.
Individual growth curve models were developed
for multilevel analysis and specifically designed
for exploring longitudinal data on individual changes
over time.23 Using this approach, we applied the MIXED procedure in SAS (SAS Institute) to account
for the random
effects of repeated measurements.24 To specify the correct model
for our individual growth curves, we compared a series of MIXED models by evaluating the difference in deviance between nested models.23 Both fixed quadratic and cubic MIXED models fit our data well, but we selected the fixed quadratic MIXED model because the addition of a cubic
time term was not statistically significant based on a log - likelihood ratio test.
So while there is general agreement that some children do have serious sensory challenges, the disagreement is
over whether SPD should be considered an independent disorder, how far sensory issues go in explaining behaviors, and whether the treatment occupational therapists offer
for sensory issues has any
effect on a child's functioning
over time.
Fever
over 100.4 º F (38º C) during labor is five
times more likely overall
for women using an epidural; 44 this rise in temperature is more common in women having their first babies, and more marked with prolonged exposure to epidurals.45 For example, in one study, 7 percent of first - time mothers laboring with an epidural were feverish after six hours, increasing to 36 percent after 18 hours.46 Maternal fever can have a significant effect on the baby (see belo
for women using an epidural; 44 this rise in temperature is more common in women having their first babies, and more marked with prolonged exposure to epidurals.45
For example, in one study, 7 percent of first - time mothers laboring with an epidural were feverish after six hours, increasing to 36 percent after 18 hours.46 Maternal fever can have a significant effect on the baby (see belo
For example, in one study, 7 percent of first -
time mothers laboring with an epidural were feverish after six hours, increasing to 36 percent after 18 hours.46 Maternal fever can have a significant
effect on the baby (see below).
As a child, I had meningitis and still suffer the after -
effects of the illness at
times, and I've done fundraising and awareness
for Meningitis UK
over the years.
Second, I tend to agree with your assumptions about mandates and obesity —
for example, the regulations require that fat calories be limited to 30 percent of the meal but
over the
time period that's been in
effect, we've only seen an increase, not a reduction, in childhood obesity.
The strongest research methods
for psychological studies are: qualitative findings versus quantitative; experimental rather than descriptive or correlational; controlled - experiment, meta - analysis, and observation designs
over archival, case study, computational modeling, content analysis, field experiment, interview, neuroimaging, quasi experiment, self - report inventory, random sample survey, or twin study; and prospective (where subjects are recruited prior to the proposed independent
effects being administered) and longitudinal (where subjects are studied at multiple
time points) rather than retrospective or cross-section study.
Having created a company to offer these keepsake videos (at a cost of # 200 a
time), he was asked
for his views: «A great deal of research has been done
over the past 30 years to investigate if fetal ultrasound has any
effect on the baby and there is no evidence whatsoever of harm.»
This
time, we achieved a substantial majority in favour of law making powers, meaning that,
for the first
time in
over 600 years, laws that
effect only Wales are made only in Wales.
When the Saxbe fix was used
for Hillary Clinton, who had the same problem, there was some debate
over whether it would be valid, due to the
timing of when the raise by the Executive Branch took
effect compared to exactly when Clinton resigned from the Senate and when her term of service began at the State Dept.. The Constitutionality has nothing whatsoever to do with Clinton's personal actions and these particulars would hold
for others too if the
timing was similar.
- GDP per capita is still lower than it was before the recession - Earnings and household incomes are far lower in real terms than they were in 2010 - Five million people earn less than the Living Wage - George Osborne has failed to balance the Budget by 2015, meaning 40 % of the work must be done in the next parliament - Absolute poverty increased by 300,000 between 2010/11 and 2012/13 - Almost two - thirds of poor children fail to achieve the basics of five GCSEs including English and maths - Children eligible
for free school meals remain far less likely to be school - ready than their peers - Childcare affordability and availability means many parents struggle to return to work - Poor children are less likely to be taught by the best teachers - The education system is currently going through widespread reform and the full
effects will not be seen
for some
time - Long - term youth unemployment of
over 12 months is nearly double pre-recession levels at around 200,000 - Pay of young people took a severe hit
over the recession and is yet to recover - The number of students from state schools and disadvantaged backgrounds going to Russell Group universities has flatlined
for a decade
The global scope of the study could help researchers set upper and lower limits
for black carbon deposition and better account
for the
effects of photodegradation, a process by which sunlight alters the molecular composition
over time.
The massive star Sirius,
for example, is just
over twice as far away as Alpha Centauri — but because it shines some 25
times brighter than our sun, it offers a stronger radiation - pressure braking
effect, allowing light sails to approach at much higher speeds.
And once the El Niño is
over, it might not be
time for celebration, since it's likely to be followed by a strong La Niña, which will bring roughly opposite
effects to the world's weather.
Its durable construction also prevents the Melt Mat from degrading
over time, a problem observed with other passive methods of snow removal, such as spreading large amounts of soot particles
over snowbanks
for a similar
effect.
This study, following real - life patients
for up to ten years, shows now that these good
effects do not diminish
over time.
The results, however, show that valuing these behaviours actually has the opposite
effect, with peer relations worsening
over time for those kids turning to consumer - culture values.
By studying access to care and health outcomes
for five years after health reform took
effect in Massachusetts, the authors also were able to distinguish how access to care and health outcomes changed
over time.
The report also took the Corps to task
for failing to keep track of the
effects of subsidence: In New Orleans, the ground sinks
over time.
«We've been targeting traditional risk factors in public health campaigns
for many years,» said Susan Cheng, M.D., M.P.H., study lead author and Assistant Professor of Medicine at Brigham and Women's Hospital in Boston, Mass. «We wanted to take a look at how well we've been doing
over time at keeping these risk factors from causing heart and vascular disease — both by preventing the risks from occurring and by minimizing their
effects when they do occur.»
In order to examine the trend of vulnerability
over time, he normalised the losses to the year 2015 by examining the
effect of historic events
for today's conditions.
Over time, this has a significant
effect on the composition of the local neighbourhood and makes the area less affordable
for poorer families.
«We suggest studies that follow users
over time and seek to answer the cause - and -
effect questions surrounding social media use and risk
for eating and body image concerns.»
Pound
for pound, the
effect of methane on climate change is more than 20
times greater than carbon dioxide
over a 100 - year period, according to the Environmental Protection Agency.
The models included terms
for time (age in years, divided by 10 so the coefficients yield
effects of decline
over 10 years), age cohorts (age at baseline in five year bands) to adjust
for secular
effects, and an interaction term between age cohort and
time, separately in men and women.
I also hope that this research can be a model
for future studies that continue to investigate climate change
effects over time and space using the fossil record.
Dec. 18, 2017 - Lawrence Livermore National Laboratory (LLNL) scientists and engineers have developed a «brain - on - a-chip» device aimed at testing and predicting the
effects of biological and chemical agents, disease or pharmaceutical drugs on the brain
over time without the need
for human or animal subjects.
The Livermore PK analysis showed that SiNPs were rapidly cleared from the circulatory system (the «central compartment» in PK models) and were distributed to various body tissues, where they persisted
over the eight - week
time course of the study, raising questions about the potential
for bioaccumulation and associated long - term
effects.
Computational biology researchers at Pacific Northwest National Laboratory developed a model
for predicting what's happening during a stroke, how the process evolves
over time, the potential outcomes, and the
effects of different treatment options.