Sentences with phrase «effects over time on»

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

«Having spare time and perceiving control over how to spend that time (i.e. discretionary time) has been shown to have a strong and consistent effect on life satisfaction and happiness, even controlling for the actual amount of free time one has.»

Over time, as people became more and more aware of the effects commonly used products can have on the environment, plastic - happy clients who once cared mostly for cost and convenience morphed into savvy customers with real concerns about the impact polyethylene and other petroleum - based products have on the ecosystem.

The app produces a set of graphs so you can compare the effect a factor had on your symptoms over time or compare the severity of two symptoms.

But, this constant work mindset can have a negative effect on your personal well - being over time.

And over time this has an insidious effect on the free media because people start to check themselves, understanding that critiquing the president can actually hurt their bosses, or their media conglomerates bottom line.

«Their courage can have a buoying effect on everyone else — but they too will become risk averse over time as they encounter failure,» she explains.

The series of studies tested the effects of power hierarchies on team productivity by creating teams with either a mixed propensity towards leadership — in one case some participants were primed to feel powerful by thinking of a time they wielded power over others while others subjects were asked to envision a time they were bossed around before joining the group — or teams made up entirely of hard charging leadership types or participants primed for a meeker, go along, get along approach.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

CAP assumes annual wage growth matches the mean effect of experience and nonexperience on real wages measured in the NLSY data assuming full - time, full - year employment, and reports the cumulative difference between the no - leave earnings profile and the leave earnings profile over time.

But none of globalization's effects on inflation, not even the potential reduction in inflationary bias, diminish the importance of the principal objective of central banks: setting policy to achieve low and stable rates of inflation over time.

Since a larger share of deposit rates are fixed than are loan rates, this will overstate the effect on cash flows over longer time horizons, though the extent of this bias has not necessarily changed over time in an obvious way.

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

Part of this decline in GDP, stemming from the oil production shortfall, will probably be made back sometime in the third quarter, but the net effect on the level of GDP over time will depend on the pace of rebuilding, which at present is difficult to foresee.

Likewise, the frightening or exuberant features of any given business cycle typically have little effect on the very, very long - term stream of cash flows that stocks actually deliver over time.

Intermittent fasting over a certain period of time is a feature of great religions all over the world and it is well known that nutritional habits, sleeping patterns and meal frequency have profound effects on maintaining human health.

This is because interest rate changes have their largest effect on inflation risk, while stronger macroprudential settings will lead to a higher quality of household indebtedness over time.

Nevertheless, the early experience suggests that, while the resilience of both borrowers and lenders has no doubt improved, the initial effects on credit and some other indicators we use to assess risk may fade over time.

S&P noted that it expected that the breach will have a «somewhat lingering effect on customer traffic at least through the first half of fiscal 2014, but this should moderate over time.»

The fact is, the Earth's magnetic field has reversed thousands of times over the Earth's lifetime, with no apparent effect on it's rotation.

Either they necessitate a deceptive «God», e.g. creating starlight «in transit» which means that for some light the star that supposedly sent said light would never have actually existed, or they would cause effect that should be evident but are not, e.g. temporarily fast starlight would effectively cook many things, such as life on earth, if the required light (and attendant gamma radiation) were compressed into a significantly shorter time frame (think of the radiation from the apparent 13 billion years of the universe arriving at the same time, or even over a 1000 years).

I personally think religion should not be a factor.No one should ask the candidates what their religious views are and they should never mention them.Their religious preferences have absolutely no effect on what type of leader they will be.Unless they are some kind of a religious fanatic.I think it's time for an atheist.There was not a Christian president for over the first 50 years of our nations existence.And, I do not think there has been one since.If you look it up you will find not one of our founding fathers were Christian.Not even Jefferson.I know he wrote the Jefferson bible, but, that's just because he, like the other founding fathers, did not believe Jesus to be of divine decent.So, he kept his philosophy while removing all the mystical and dogmatic concepts.

However rational the hoarder's strategy may appear in the moment, it has a terrible effect on the body politic over time.

«Over time, the effect on the reward centre in the brain is similar to what makes drug addicts go back for another line of cocaine.»

We've added the following section to shed more light on the effects of hot dogs and other processed meats on the body over time.

I know some of you aren't going to like that and I do hope that rather than taking the time to comment or email to that effect, that you'll just go ahead and decide that you're going to trust me on this one and head over to Amazon and buy a scale =)

While toasting on the tawa, make sure you toast them over low flame taking enough time for the crispy and crunchy effect and for even browning of the bread slices.

I don't mean to support someone else I just mean don't spend any of your hard earned cash or time on this club, don't over hype our very limited abilities and don't let our awful performances effect your week or Saturday or Sunday.

Patience Crystal Palace game last weekend was a classic example of how Arsenal got frustrated, over time, and the effect it had on their, otherwise, slick passing and incisive movement.

These are usually pretty strong over-the-counter medications and could have more adverse effects on your own body if you continue to take them over a longer period of time.

You can perfect the technique for some of these moves over a period of time but it will be fine to simply perform the movements as best as you can as it won't take you too long to master the moves and develop a 20 - 30 minute workout that should have a positive effect on your body.

Small but constant deficits in sleep over time lead to escalating and most likely long - term effects on brain function.

Very little is known about the direct effects of drinking on breastfeeding; a 2017 study showed that over half of Australian women who breastfeed drink at low levels, and use strategies, such as timing when they drink and breastfeed, which does not seem to be harmful to babies at 12 months.

Finding a way to reconcile two competing demands - minimizing contact in practice in order to reduce the number of concussions sustained and the number of hits players sustain over the course of a week and a season that emerging science, now more than ever, suggests may have a deleterious cumulative effect [26] on a player's cognitive function over the long term, while at the same time maximizing the amount of time in practice learning how to tackle and block without head - to - head contact - time that is needed to maximize the protective effect of proper tackling on the number of head - to - head hits players sustain in game action, which can not only result in concussion, but catastrophic neck and spine injuries - is challenging, but clearly not impossible.

And while you may think 45 minutes isn't a big deal, try doing the maths — 45 minutes every night over just one month (multiply by 30 nights), could really have an effect on your energy levels and day - time functioning.

Individual growth curve models were developed for multilevel analysis and specifically designed for exploring longitudinal data on individual changes over time.23 Using this approach, we applied the MIXED procedure in SAS (SAS Institute) to account for the random effects of repeated measurements.24 To specify the correct model for our individual growth curves, we compared a series of MIXED models by evaluating the difference in deviance between nested models.23 Both fixed quadratic and cubic MIXED models fit our data well, but we selected the fixed quadratic MIXED model because the addition of a cubic time term was not statistically significant based on a log - likelihood ratio test.

So while there is general agreement that some children do have serious sensory challenges, the disagreement is over whether SPD should be considered an independent disorder, how far sensory issues go in explaining behaviors, and whether the treatment occupational therapists offer for sensory issues has any effect on a child's functioning over time.

Fever over 100.4 º F (38º C) during labor is five times more likely overall for women using an epidural; 44 this rise in temperature is more common in women having their first babies, and more marked with prolonged exposure to epidurals.45 For example, in one study, 7 percent of first - time mothers laboring with an epidural were feverish after six hours, increasing to 36 percent after 18 hours.46 Maternal fever can have a significant effect on the baby (see below).

(2) The audio - visual effects of the lights feature are great, but seem to be overwhelming to the baby (and adults as well) with too many lights flickering on and off at the same time and over stimulating the baby.

Relationship / personal continuity over time has been found to have a greater effect on user experience and outcome (Saultz 2003; Saultz 2004; Saultz 2005).

Having created a company to offer these keepsake videos (at a cost of # 200 a time), he was asked for his views: «A great deal of research has been done over the past 30 years to investigate if fetal ultrasound has any effect on the baby and there is no evidence whatsoever of harm.»

I appreciate that cost and down - time are important factors in bridge building, but spread over generations relatively small investments in superstructure can have a positive effect on community pride, maybe even tourism.

When the new cashless system on the I - 190 over Grand Island goes into effect near the end of the month, drivers who don't have an E-ZPass should have an easier time dealing with billing problems than what motorists who use the Gov. Mario M. Cuomo Bridge between Rockland and Westchester counties have had to handle.

If this pattern continues over time it will have an adverse effect on the CPS budget impinging on the organisations ability to effectively prosecute cases.»

To track the effect of the video game on real - life fruit and vegetable consumption at baseline and six months later, researchers completed 24 - hour dietary recalls with children over the phone three times, averaging breakfast, lunch, snack, and dinner fruit and vegetable intakes.

«We would anticipate that over time, a large number of functional variants [of HTR2B] will be identified, with a range of behavioural effects,» says David Goldman at the US National Institute on Alcohol Abuse and Alcoholism in Bethesda, Maryland, and head of the team that carried out the work.

The passing on of knowledge from generation to generation is metaphorically referred to as a cultural «ratchet effect,» which creates greater complexity of culture over time.

Other heavy metals such as mercury, lead and cadmium have no known vital or beneficial effect on organisms, and their accumulation over time in the bodies of mammals can cause serious illness.

«Our results suggest that both the clinical effectiveness and the impressive effects on the quality of life under biological treatment as used in clinical practice are sustained over time.

The goal is two-fold: One, get samples from the sand sheet and learn more about how ash and other particles that landed there from a nearby volcano have changed over time, especially from the effects of wind — a common, persistent weathering agent on Mars.