Animal studies also found that alternative tobacco products without nicotine produced similar or stronger
effects than products that include nicotine.
Not exact matches
These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our
products or
products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways
than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our
products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their
products; there may be a reduction in payment rate or reimbursement for the company's
products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's
products; the company's
products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side
effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.
I expect, however, that there will be three first - order
effects that will be very similar to those that followed the BP spill: 1) increased public consciousness of the dangers inherent in transporting oil and oil
products and more aversion to having these
products moved nearby; 2) increased calls for alternatives to oil rather
than alternative means of transporting oil; and 3) decreased trust in regulators» and firms» abilities to sufficiently mitigate risks from transporting oil.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new
products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's
products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger
than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the
effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new
product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current
products, including Biktarvy; Gilead's ability to successfully commercialize its
products, including Biktarvy; the risk that physicians and patients may not see advantages of these
products over other therapies and may therefore be reluctant to prescribe the
products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's
product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
If you factor in the
effect of the discount points lowering the mortgage rates, then a few of SunTrust's mortgage
products actually charge higher rates
than usual.
Plant - based dairy
products such as milk continue to take market share from the sales of conventional milk in the U.S., with sales in the former category growing as sales in the latter category decline.45 It seems likely that cultured meat
products will have similar
effects, sometimes replacing plant - based
products, but also replacing
products of animal agriculture — particularly because they will likely be harder to distinguish by taste and texture
than current substitutes.
They work with corporations to increase the availability of animal
product alternatives and have developed a «restaurant report card» to score the top 100 chain restaurants according to their plant - based options.22 In general, we think that corporate outreach is a relatively effective animal advocacy intervention, though we are less certain of the
effects of promoting plant - based options in restaurants
than we are of the
effects of working with corporations to implement welfare reforms.
Other
than the lessons discussed above, one must understand the science of social networks and network
effects — that people tend to be friends with others like them, or that a
product or service is more valuable the more people use it, for example.
With the passage of years it becomes hard to say whether we are what we are primarily because of the cumulative
effects of all our past experiences or whether our recent past experiences are more the
product of new influences and circumstances
than of the remote past.
1) Charities spend their income on necessities, such as food and utilities, which ever - so - slightly re-orients our economy toward recession - resistant
products, rather
than luxuries 2) Charities spend their money quickly, but on independent schedules, making for a smoother stimulus
effect on the economy 3) Charities make purchases tax - free, meaning that $ 1 spent by a charity generates a full $ 1 of private economic activity; furthermore, much of those tax revenues are recovered as income tax on the grocery stores, utility companies, etc. that might not have received that income otherwise 4) Charitable giving is by far the most democratic way to improve society; from birth control to bombers, government assuredly spends money on something you don't like, and charitable giving restores your say - so 5) Charitable donations are tax deductible, meaning you keep those tax dollars in your local community 6) Charitable donations provide the funds necessary for volunteers to serve the needy, thus giving «the average citizen» a chance to meet and interact with the needy, breaking down stereotypes
The gluten in Einkorn is said to have a completely different
effect on the body
than the gluten found in our modern - day wheat, possibly the reason why many people with gluten sensitivities can enjoy
products made with Einkorn wheat.
Although the two plants are related, hemp
products contain only trace levels of THC (less
than 10ppm) and will not cause a psychoactive
effect.
Amid growing concerns about the health
effects of cheese, plant - based milk options such as almond and coconut brands have become popular alternatives, capitalising on the growing interest in digestive health by positioning
products as easier to digest
than dairy options.
«Valio Gefilus juices have been selling well for many years and it struck us as an interesting concept, especially for consumers in Norway who want the health
effect but would prefer to get it from a juice rather
than a fermented milk
product, or are lactose intolerant or simply don't enjoy milk,» he said.
Simply put, in the unlikely event
product is contaminated in the plant or compromised en route, U.S. suppliers can quickly identify the
effected product (typically in less
than two hours) and retrieve it.
Both front - of - pack formats enhanced discrimination in the presence of a reduced salt claim, but the Traffic Light label also performed better
than the Percentage Daily Intake label in moderating the
effect of the claim for the high - sodium
product.
Also, several studies show that cold and cough
products don't work in children younger
than six years and can have potentially serious side
effects.
However, take care not to leave diapers out longer
than neccessary, as UV rays and high temperatures can also have an ill
effect on diapering
products.
Depending on the nature of the cosmetic
product, certain beauty items have harsher
effects to an unborn child
than others.
«We considered that a claim that a
product provided calcium «for strong bones» implied a greater health
effect than a claim that calcium was needed «for normal growth and development of bone».
Despite tobacco industry claims of heat - not - burn
products being less harmful
than regular cigarettes, the health
effects of the devices are still unproven, according to researchers.
Calling for better regulation and oversight of marijuana edibles, Vandrey and his team say patients who consume underlabeled
products — meaning more THC is in the
product than is stated on the label — could suffer from overdosing side
effects, including extreme anxiety and psychotic reactions.
And the data showed that those who bought
products that more closely matched their personalities reported higher satisfaction with their lives, and this
effect was stronger
than that of their total income or total spending.
Next, they removed large macromolecules like antibodies as well as salt fragments, and discarded all molecules that exert their biological
effects through mechanisms other
than protein - ligand interactions, are not used to treat diseases or are found only in topical
products.
Further experiments showed that it is rather the metabolic
products of the microbiome
than a single bacterial strain which is holds responsible for the observed
effects.
Canned fruit
products are almost four times more popular
than frozen fruit in Europe *, so it is likely that canned fruit dominated this
effect.
«Our evidence shows that it could be applied to other
products successfully, though I expect the size of the
effect to be smaller
than what we found in our study.
The nutmeg compound binds TRPM8 at a different site
than menthol does, meaning it could complement menthol's
effects if the two were combined in a
product.
The
effects reached well beyond the state, as manufacturers opted to adhere to a single safety standard rather
than producing one set of
products for California and another for the rest of the U.S.
For example, dairy
products such as cheese have a lesser
effect on blood cholesterol
than would be predicted on the basis of their content of saturated fat.
More
than 40 closed - circuit cameras affixed above and below the Concordia will be monitored for debris left behind, which could include mattresses, luggage and other personal
effects, and chemicals such as engine oil or cleaning
products containing bleach and ammonia.
The rest of the
products had a weak repellent
effect or were no better
than no protection at all, the researchers report today in the Journal of Insect Science.
Fragranced
products such as soaps, candles and air fresheners cause more
than one - third of U.S. adults to suffer ill health
effects, including headaches, dizziness and breathing difficulties, researchers said.
Though scientists are still arguing over the
effects of soy on cancer and heart health, one thing is for certain: «Consuming too much soy - based vegan «meat» is arguably worse (
than) consuming high - quality animal
products,» says Henderson.
These
products have enjoyed greater sales success
than weight loss drugs, which often fail to live up to claims, present serious side
effects and fail to get government approval.
The combination of grape extract and physical activity offers more protection
than physical activity alone 06.03.2018 Betaine forces fat cells to eat themselves 17.02.2018 Nine easy ways to lose body fat 13.02.2018 Sewage water during bodybuilding competitions full of DNP 04.02.2018 «Safe» DNP cycle, fatal outcome 27.01.2018 Paleo diet makes fat cells lazy (and if you're trying to lose weight, that's exactly what you want) 21.01.2018 Legumes facilitate weight maintenance and fat loss 20.01.2018 More sleep = less sugars in your diet 17.01.2018 Low intensity cardio before breakfast burns more fat if you take some L - phenylalanine 29.12.2017 Slimming goes better with a couple of tablespoons of chia daily 23.12.2017 Better weight loss results with intermittent low - calorie diet 01.12.2017 Circuit training with light weights causes just as much fat loss as classic cardio training 23.11.2017 Allulose, the low - calorie carb that boosts fat burning 19.11.2017 Alpha - linolenic acid - diacylglycerol steps up fat burning 16.11.2017 People who use light
products are fatter 30.10.2017 This is what happens if you eat 14 g goji berries every day 17.10.2017 Soft drink ruins slimming
effect of high - protein diet 14.09.2017 When children take 8 g inulin daily their fat layers stop growing 09.08.2017 Enhanced fat burning through green and white tea - brown fat cells play key role 13.07.2017 Short interval training between meals keeps a slimming diet on course 15.06.2017 Exercising before breakfast trains your fat tissues to break themselves down 01.06.2017 Lose weight without noticing it: drink water when you're thirsty 20.05.2017 Animal study: plant - based proteins with bad amino acid profile make you fatter 14.05.2017 Weight loss diet while physically inactive speeds up loss of muscle mass 12.05.2017 Lose weight faster
than you'd believe possible: skip breakfast and jog for an hour 09.05.2017 Skip breakfast - a slimming trick that works 03.05.2017 Eating whole grain
products instead of refined ones saves you a hundred kilocalories a day 01.05.2017 Another fat browner: curcumin 27.04.2017 Two cups of green tea daily results in more brown fat 25.04.2017 Boost your flavonoid intake and lower your fat percentage 21.04.2017 Not a breakfast eater?
He claims to have eaten only animal
products — limiting himself mainly to rib - eye steaks — for more
than a year, while suffering no ill health
effects and watching his gains in the gym soar.
«The evidence indicating healthful
effects of milk and milk
product consumption on prevention of cancers is considerably greater
than those representing harmful impacts.
It is noteworthy that the antinociceptive
effect of the fermented dairy
product (inclusive of the aforementioned bifidobacterium strain plus Lactococcus lactis and two yogurt starters L. bulgaricus and S. thermophilus) was more effective
than an equivalent dose of Bifidobacterium lactis CNCM I - 2494 alone [35].
There is mounting evidence that in sum regular dairy consumption saves more lives
than dairy avoidance, as a marginally increased risk of certain cancers is by far outweighted by the CVD - and diabetes - protective
effects of dairy (particularly low - fat and fermented dairy
products).
These observations indicate that although GOS promotes bifidobacterial growth more
than FOS does, the latter sugar produces a more robust neurochemical boost.Thissuggests that the two prebiotics and their breakdown
products have different
effects on the microbiome and neurochemicals and their receptors.
do try to stick with real natural foods rather
than consume large amounts of «food
products» with these additives — as they likely will have an additive
effect in your intestine!
By eating the healthy, clean Prolon
products for just 5 days, I have experienced the lasting
effect of being 7 pounds lighter, more energy and mental clarity
than ever, and most importantly, adopting positive nutritional habits after just one round of Prolon.»
More
than 10,000 women using these
products have suffered from side
effects, and as a result have filed lawsuits against the makers of these drugs.
It is free from any major side -
effects and more
than 90 % of the reviews about this
product are positive.
It's sometimes difficult to explain to our friends and customers that Manuka Honey isn't some fad, but actually has verifiable
effects on skin health and has been used for a lot longer
than most drug and chemical - infused
products out there.
Buyer Be Aware Reports Timely articles about widely used drugs and other
products that may be more dangerous
than you think and may have side
effects you haven't been told about.
The metabolic
effects of a ketogenic diet imply a higher -
than - usual oxidation of fats, which leads in turn to reduced respiratory exchange ratio values.20, 97 Metabolic carbon dioxide output may be calculated as the
product of alveolar ventilation multiplied by the fractional alveolar carbon dioxide concentration.
Once the
product dissolves in your stomach, it causes an osmotic
effect, increasing the concentration of the solutes inside the intestines higher
than the ones outside the surrounding tissue.
Product Performance: Unlike thick wooden pencils that tug and look unnatural, this automatic fine liner is four times smaller
than the average pencil, so it perfectly mimics actual brow hair for a more natural
effect.