Sentences with phrase «effects than the treatments»

Not exact matches

And herein lies a very broad and «mushy middle,» says McKenna, with the effect, in many cases, being the same: «It's still using smaller - than - treatment doses, or sub-therapeutic doses of antibiotics,» which creates a literal breeding ground for resistant microbial strains.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Dog owners find it more effective than other topical flea treatments, and they say side effects are rare.

Although some doctors do use it as part of treatment, it often carries riskier side effects than what you want to treat.

Abiraterone, approved in 2011 for the treatment of metastatic prostate cancer, has a «food effect» that is greater than any other marketed drug.

They found that the synthetic odors mimicked the effect of the presence of a live queen in a nest — fewer workers» ovaries were activated and more regressed when exposed to the odor treatment than in non-odor controls.

No major toxic effects were observed, and the patient «was able to survive a much longer period than expected with an improved quality of life, which is clearly attributable to the treatment with 3BP,» the scientists concluded.

Breast cancer patients who have radiotherapy targeted at the original tumour site experience fewer side effects five years after treatment than those who have whole breast radiotherapy, and their cancer is just as unlikely to return, according to trial results published in The Lancet.

A non-hormonal option for male contraception is preferable to hormonal treatments currently in clinical trials, because the types of hormones that make men infertile have more severe side effects than those used in the female pill.

Researchers at New York Eye and Ear Infirmary of Mount Sinai showed that a microdose delivery system achieved a treatment effect comparable to a conventional eyedropper, while delivering less than four times the amount of drug.

Since children of mothers with preclinical RA also had an increased risk of epilepsy, Rom said the findings point towards an important role of the disease itself rather than an effect of treatments for RA.

Originally offered as a radical treatment for severe obesity, the surgery's effects on the digestive system and metabolism have turned out to be far more mysterious and fascinating than anyone expected.

«If they progress more slowly than usual within that time frame, that would suggest these treatments are having their desired effect.»

Instead, researchers told the European Breast Cancer Conference that their findings suggest that extending screening programs to older women results in a large proportion of women being over-treated, and at risk from the harmful effects of such treatment, because these women were more likely to die from other causes than from any tumors detected in the early stages of growth.

At this stage, the aims of the trials would be modest, seeking only to assess whether the treatments have a measurable effect, rather than expecting dramatic clinical improvement of the patients» condition.

In the lab, the antibiotics had no harmful effect on normal cells, and since they are already approved for use in humans, trials of new treatments should be simpler than with new drugs — saving time and money.

The conclusion: Ginkgo biloba «appears to be a safe and effective alternative to the current therapeutic alternatives for the treatment of dementia» and has fewer side effects than Tacrine, a popular prescription medicine for the condition.

Some of these patients are likely to experience more adverse side - effects and complications from the treatment than from the cancer itself.

To explain why antidepressants in such trials nevertheless often cause greater symptom relief than placebo, it has been suggested that SSRI - induced side effects will make the patient understand that he or she has not been given placebo, hence enhancing his or her belief of having been given an effective treatment.

By combining this inhibition of FAK with radiotherapy, the group was able to achieve a greater treatment effect than with either therapy alone.

Thus, so far, it has never been investigated whether individuals in clinical trials experiencing side effects from antidepressant medication, and for this reason may have guessed that they have not received placebo, also respond more favorably to treatment than those without side effects.

«So the exact mechanisms behind the observed increase in risk are still unknown,» explained Dr Jensen, «but it is generally believed that underlying infertility has a more important role in adverse effects in the offspring than the treatment procedures.

The effect of hormone treatments on bone mineral density (BMD) is another issue for spaceflight, where astronauts lose bone at a much higher rate than on Earth.

Six months prior, the U.S. Food & Drug Administration (FDA) approved sofosbuvir, an oral medication shown to cure most cases of hepatitis C infection, with fewer side effects than the current treatment options.

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

The latter investigations may inflate a treatment's effects even more than online patient reviews do, Ioannidis asserts.

«Identifying a cancer driver is crucial for cancer treatment because it allows the use of targeted therapies, which have less side - effects than conventional chemotherapy drugs, against a particular protein,» said Kurokawa.

They hypothesized that excess brain dopamine release in heavy alcohol users who also use nicotine / smoke could make them more treatment - resistant in general, but more sensitized to naltrexone's dopamine lowering effects — leading to their greater response to treatment with the medication than non-smokers.

Such a treatment in humans, Glick says, might have fewer side effects than the immune - suppression drugs currently used to treat the condition.

The treatment is associated with side effects so doctors do not treat patients longer than necessary.

Clinical trials of weight loss have been shown to improve participants» mood, but this could be a result of the supportive environment rather than the weight loss itself, as the effects are seen very early on in treatment and are not related to the extent of weight loss.

The effect of physiotherapy alone was no better than watchful waiting (no treatment).

The authors noted that low croploads during the study period may also have contributed to reduced effects of treatments on cherry quality characteristics other than size.

Though behavioral parent training is known to have positive results for children with ADHD, fewer parents and mental health and medical practitioners know about it than medication prescribed for ADHD, which can come with side effects and is not recommended as a first - line treatment for preschool - age children, DuPaul said.

A move to lengthen limbs internally rather than via an external scaffold could reduce the effects of painful treatments, especially among younger patients

This result implies that only large treatment effects can be detected by efficacy studies in hAPP mice, since the number of mice per group will likely not be greater than 50, for practical and ethical reasons.

The effect of glucocorticoid treatment is most prominent on trabecular bone and is therefore likely to be larger on vertebral bone than on hip bone.3 Glucocorticoids are associated with an increased rate of fracture, and higher doses and longer use of glucocorticoids are associated with higher risks of fracture.4 Compared with patients not taking glucocorticoids, the risk of hip and vertebral fracture among patients taking glucocorticoids is increased by 60 % and 160 %, respectively.4 Among 80 - year - old patients, the hip fracture risk is increased by a magnitude of 2.1 and is independent of BMD.5 Most studies indicate that fracture risk is increased following at least 3 months of treatment with daily doses of 5 mg of prednisolone or more in older men and women.4

Understanding this interaction will lead to targeted treatment «block the interaction» rather than the non-specific dampening of inflammation such as by corticosteroids with its many well - documented side effects and limited efficacy.»

Blacks were more likely to think their cancer was not aggressive and were more likely to worry about the treatment's cost and side effects than their white counterparts.

In particular, it is crucial to find out whether this is associated with the timing of the treatment or possible side effects of it rather than the stem cell transplant itself.

The failure in pancreatic cancer treatment is main due to the presence of a dense and poorly vascularized stroma that increase the drug clearance in the tumors rather than the healthy tissues, decreasing drug bioavailability in the target tissue and leading to significant side effects.

There are a wide range of therapeutic treatments [1], although none have shown any more than modest clinical effects [2].

The whole animal studies suggest that the experimental drug could have fewer side - effects than current treatments.

Because of the early stage of the trials, more work is needed to see «if the vaccines are better than existing treatments, if they improve survival, and what their long - term side effects could be.»

The team's work may pave the way for obesity treatments with fewer side effects than current medications and negate the need for invasive surgeries.

The system was shown to work nearly as well as — or in some cases better than — when the drug was freely moving, the type of scenario that causes the commonly experienced cancer treatment side effects.

Synergy between drugs occurs when the result of treatment with both together is more dramatic than would be expected by adding the two effects.

But she warned that the net effects could be more detrimental than beneficial, too, so any such potential treatment would need to be tested carefully.

The therapy, which is described the week of February 13, 2017, in Proceedings of the National Academy of Sciences, can be effective longer and likely has fewer side effects than existing treatments, and could be produced much more cheaply.

Treatment takes less than a second and does not have any known side effects.