Not exact matches
In particular, the complaint alleges that throughout the Class Period, defendants made materially false and / or misleading statements and / or failed to disclose that (1) the trials
for GED - 0301 suffered from fatal design defects, such that GED - 0301 had failed to demonstrate meaningful clinical
efficacy; (2) the growth
of Otezla sales had dramatically slowed during Celgene's third fiscal quarter
of 2017; and (3) the clinical and nonclinical pharmacology data in Celgene's new
drug application («NDA»)
for Ozanimod were insufficient to permit a complete review by the FDA, which resulted in the FDA issuing a refusal to file letter to Celgene regarding the NDA.
Topics included: early reporting on inaccuracies in the articles
of The New York Times's Judith Miller that built support
for the invasion
of Iraq; the media campaign to destroy UN chief Kofi Annan and undermine confidence in multilateral solutions; revelations by George Bush's biographer that as far back as 1999 then - presidential candidate Bush already spoke
of wanting to invade Iraq; the real reason Bush was grounded during his National Guard days — as recounted by the widow
of the pilot who replaced him; an article published throughout the world that highlighted the West's lack
of resolve to seriously pursue the genocidal fugitive Bosnian Serb leader Radovan Karadzic, responsible
for the largest number
of European civilian deaths since World War II; several investigations
of allegations by former members concerning the practices
of Scientology; corruption in the leadership
of the nation's largest police union; a well - connected humanitarian relief organization operating as a cover
for unauthorized US covert intervention abroad; detailed evidence that a powerful congressional critic
of Bill Clinton and Al Gore
for financial irregularities and personal improprieties had his own track record
of far more serious transgressions; a look at the practices and values
of top Democratic operative and the clients they represent when out
of power in Washington; the murky international interests that fueled both George W. Bush's and Hillary Clinton's presidential campaigns; the
efficacy of various proposed solutions to the failed war on
drugs; the poor - quality televised news program
for teens (with lots
of advertising) that has quietly seeped into many
of America's public schools; an early exploration
of deceptive practices by the credit card industry; a study
of ecosystem destruction in Irian Jaya, one
of the world's last substantial rain forests.
Rather, it's the no - holds - barred sales practices that Alexion allegedly engaged in — which, in some cases, reportedly led to salespeople bullying doctors into prescribing the
drug for patients even when the
efficacy of the treatment was unclear.
These risks and uncertainties include, among others: the unfavorable outcome
of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any
of our products or products using our proprietary technologies, which may lead to competition from generic
drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components
of our filings
for our products, including our clinical trial designs, conduct and methodologies and,
for ALKS 5461, evidence
of efficacy and adequacy
of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results
of our clinical development activities may not be positive, or predictive
of real - world results or
of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement
for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights
of third parties, or have unintended side effects, adverse reactions or incidents
of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.
Insurers like Anthem have refused to cover the exorbitantly pricey treatment (around $ 300,000) since the
drug's label admits that Exondys hasn't proved its
efficacy, making the therapy a roll
of the dice
for payers and patients alike.
The ongoing American Heart Association (AHA) meeting in New Orleans is producing a deluge
of data — including some promising prospects
for a class
of next - generation cholesterol
drugs that have been slow to take off so far in the U.S. So - called PCSK9 inhibitors have shown tremendous
efficacy in lowering LDL - C, or «bad» cholesterol.
Immuno - oncology
drugs have proven promising and effective
for many patients; but they also don't produce a response in a sizable chunk
of the patient pool and may eventually wane in
efficacy.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues
for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement
for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount
of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability
of funding
for state AIDS
Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the S
Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction
of generic versions
of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect
of lowering prices or reducing the number
of insured patients; the possibility
of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels
of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits
of the Sangamo partnership; Gilead's ability to submit new
drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the S
drug applications
for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all,
for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages
of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and
efficacy data from clinical studies may not warrant further development
of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate
of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
We do this by conducting clinical trials in which we collect safety and
efficacy data about our experimental
drugs with the goal
of submitting those data to regulatory authorities, like the U.S. Food and
Drug Administration (FDA) and the European Medicines Agency (EMA), so that these experimental
drugs can be approved
for use by patients.
In the argument
for the spiritual
efficacy of drugs, much is made
of feeling or failing to feel God's presence.
BY NATHAN RILEY Outraged that Mayor Bill de Blasio continues to sit on a city health department study into the
efficacy of establishing safe places
for drug users to pursue their high — facilities that are in place all over Europe with proven track records
of reducing fatal overdoses — protestors sat down in the middle
of Broadway across from City Hall bringing downtown traffic to a halt.
«This phase III trial will be noteworthy
for being the first prostate cancer trial to assess a biomarker, namely AR - V7 in circulating tumour cells, as a predictor
of response at the same time as testing the
efficacy of the
drug,» Prof Taplin will conclude.
The only remaining need
for the live virus was to test the
efficacy of drugs in vitro, it said.
The time it takes
for a new
drug to go from bench to prescription pad can be staggering — typically three to six years are needed
for development before it's even ready
for safety and
efficacy testing, according to the Pharmaceutical Research and Manufacturers
of America.
The CO-STAR (Hepatitis C Patients on Opioid Substitution Therapy Antiviral Response) trial sought to evaluate the
efficacy and safety
of elbasvir - grazoprevir
for injection
drug users.
Neurologist Malcolm MacLeod
of the Centre
for Clinical Brain Sciences at the University
of Edinburgh and his colleagues combed through papers reporting the
efficacy of drugs in eight animal disease models and checked whether the authors reported four measures that are widely acknowledged to reduce the risk
of bias.
Respondents in this year's survey pointed to five main causes
of the field's less than favorable reputation:
drug and product recalls such as the withdrawal
of Avandia; safety issues such as the discovery
of problems with raw material from China used in medical products; scandals, including evidence that pharmaceutical companies have failed to release data from trials whose results cast doubts on their
drugs» safety and
efficacy; lawsuits brought against companies that failed to warn patients
of problems with their products; and ethical issues such as kickbacks
for physicians promoting specific medications.
Schlom,
of the National Cancer Institute, says the next challenge
for researchers is to find ways to combine different immunotherapy
drugs into single treatments and measure their
efficacy in clinical trials.
Andrew Murkin
of the University at Buffalo, New York, says Schramm's
drugs are so well tailored to block a specific enzyme that there is the potential to lower the dosage needed
for efficacy.
The determination
of each
efficacy level was also based on the rigor and quantity
of published studies on the
drug class: to be in Level A,
for example, a class
of drugs must have been supported by at least two «Class I» studies — well - designed, double - blind, randomized, placebo - controlled clinical trials.
With the initial contract
of $ 24.9 million over the next 18 months, Mapp Pharmaceutical will manufacture a small amount
of the
drug for early - stage clinical studies to demonstrate its safety and
efficacy in people.
The documentation ranges across the whole spectrum
of drug development: Investigators» brochures provide information on all that is currently known about the medicine and so need periodic updating; accurate and concise protocols are required to ensure that trials are performed effectively; clinical trial reports (generally from phase II and III studies) present the information gathered from the trials; higher level documents provide summaries
of efficacy and safety data from clinical trial programmes; expert reports provide critical interpretation
of the results; and response documents clarify any points that are not clear to the regulatory agencies or provide additional analyses or supporting data
for any items
of concern.
Exploiting the same pre-clinical model used
for their studies, the researchers are testing the
efficacy of this kind
of drug candidates against cancer stem cells, and the possibility
of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective
of their possible application
for the treatment
of human breast cancer.
Downing and the team evaluated the strength
of clinical trial evidence supporting FDA approval decisions
for new
drugs by characterizing key features
of efficacy trials, such as trial size, design duration, and end points.
«These findings do not only contribute to new insights on the effects
of anti-estrogen but also the potential
of using miRNA
for monitoring
drug efficacy and
for future RNA - based therapy developments.
«Further prospective studies are warranted
for teens between 10 and 18 years
of age to determine the most appropriate Vancomycin dosing to maximize
drug efficacy and reduce the risk
of Vancomycin induced renal toxicity.»
Those traditional statistics jobs aren't going away anytime soon, as long as society continues to need workers who can advance statistics theory, assess
drugs» risks and
efficacy, or do any
of the other things statisticians have done
for years.
Conventional
drug discovery remains a hit - and - miss affair and Hunter believes the 50 percent failure rates seen
for experimental compounds in mid - and late - stage clinical trials due to lack
of efficacy is unsustainable, forcing a shift to AI.
For instance,
drug companies have manipulated research in ways that have led to questionable science supporting questionable claims
of a
drug's
efficacy.
But the three -
drug approach has since been fast - tracked
for approval, assuming a large - scale
efficacy test
of 10,000 people confirms positive results at the end
of May.
The data obtained from this study provide a basis
for more rapid, cost - effective clinical trials to evaluate new influenza
drugs or to determine the
efficacy of candidate vaccines
for both seasonal and pandemic influenza.
The Phase 2/3 trials will be sponsored by Vtesse, a new biotech company that was formed specifically to evaluate the safety and
efficacy of cyclodextrin
for the treatment
of NPC and ultimately obtain FDA labeling if the
drug is effective.
Two new phase III clinical trials investigating the
efficacy and safety
of bitopertin, a glycine uptake inhibitor considered to be a promising new add - on therapy
for treating negative symptoms in schizophrenia, failed to show a benefit
of the
drug over placebo.
This knowledge may be used to develop new ways
for opening the blood - brain - barrier to increase the
efficacy of the brain cancer
drugs and
for the design
of treatment regimes that strengthens the integrity
of the blood - brain barrier.»
These results provide evidence
for the clinical
efficacy of more subtype - selective α2AR
drugs.
A team at the Wyss Institute
for Biologically Inspired Engineering designed a better variant
of the widely - used
drug erythropoietin (EPO), showing how rational design can improve in vivo
efficacy and safety
of protein therapeutics, reduce potential side effects, and also accelerate new
drug development.
Drugs that target KORs have shown promise as therapeutic candidates because
of their
efficacy for treating chronic itch and relieving pain.
Improved diagnostic tests are on the horizon, but we need huge efforts to increase their accuracy, use them
for active case finding in the community, and eventually make them available in low income countries so as to inform treatment decisions and preserve the
efficacy of any new antibiotic
drugs for TB,» says lead author
of the Commission Professor Keertan Dheda, University
of Cape Town.
«It's not feminist to accept a lower standard
of drug efficacy and safety
for women than
for men,» she says.
It costs millions
of dollars to develop
drugs and get them tested in animals before they can ever be used in clinical trials
for safety and
efficacy in humans.
After participating in an 8 - week baseline period followed by 12 weeks
of brivaracetam treatment, patients became eligible
for long - term follow - up to monitor the
drug's
efficacy and safety.
Changes in these proteins have a great influence on
drug efficacy and side effects since they are responsible
for the metabolism and transport
of many
drugs, and are also affected by changes in the intestinal flora.
The group
of researchers at the University
of Helsinki and Aalto University, Finland, has applied privacy - aware methods
for example to predicting cancer
drug efficacy using gene expression.
Nor did the article give a hint
of the ferocious battle among doctors about the safety and
efficacy of tPA: While a number
of professional associations endorsed the
drug, many others, such as the American Academy
of Emergency Medicine, said it should not be considered the standard
of care
for acute stroke.
«We are exploring alternative directions
for developing this compound, including potential use
of the animal
efficacy rule,» Cihlar said, referring to a regulatory mechanism under which the U.S. Food and
Drug Administration may consider efficacy findings from adequate and well - controlled animal studies of a drug in cases where it is not feasible or ethical to conduct human tri
Drug Administration may consider
efficacy findings from adequate and well - controlled animal studies
of a
drug in cases where it is not feasible or ethical to conduct human tri
drug in cases where it is not feasible or ethical to conduct human trials.
For eventual human application, lowest doses
of a
drug are always desirable but this must be balanced with
efficacy of the compound.
New York, NY and Waltham, MA — September 18, 2007 — The Spinal Muscular Atrophy Foundation and BG Medicine today announced a collaboration to discover plasma biomarkers
of drug efficacy for spinal muscular atrophy (SMA), the leading genetic cause
of mortality in infants and toddlers.
«The circadian clock regulates certain signaling pathways that are key
for minimizing
drug toxicity in normal tissues and increasing anticancer therapeutic
drug efficacy,» said Shobhan Gaddameedhi, PhD, College
of Pharmacy, Washington State University, Pullman, Washington, and senior author
of this study.
He has co-authored more than 100 scientific papers, abstracts, and letters examining the
efficacy, safety and effects
of drug therapies
for cancer.
Preclinical
drug efficacy can be evaluated either in a: > prophylactic regimen starting at 3 weeks
of age upon disease initiation and lasting
for 7 weeks up to the 10th week
of age
of the animals.