Sentences with phrase «efficacy of treatment with»

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

«Until we have further evidence on the efficacy of medical cannabis for the treatment of sleep apnea, and until its safety profile is established, patients should discuss proven treatment options with a licensed medical provider at an accredited sleep facility,» said lead author Dr. Kannan Ramar, professor of medicine in the division of pulmonary and critical care medicine at Mayo Clinic in Rochester, Minnesota.

The trial needs to involve at least 50 people with OCD and a credible control treatment to really test the efficacy of this idea, says Jon Abramowitz, a clinical psychologist at the University of North Carolina at Chapel Hill.

Now, immunotherapy — a type of treatment that harnesses the patient's immune system to combat the disease — represents the future of cancer treatment, with its efficacy being demonstrated in even the most aggressive types of cancer.

The estimation of EGFR mutation status is essential for the identification of non-small cell lung carcinoma (NSCLC) patients who may benefit from treatment with EGFR tyrosine kinase inhibitors (TKIs), and hence for improving therapeutic efficacy.

Further trials are planned to document the efficacy and safety of the combination in patients infected with the other HCV genotypes and in particularly vulnerable groups, to enable a public health approach to the treatment of hepatitis C.

Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of drug candidates against cancer stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.

NIAID researchers and colleagues sought to confirm the presence of piperaquine - resistant infections in Cambodia by comparing the efficacy of dihydroartemisinin - piperaquine treatment in 204 malaria - afflicted participants aged 2 to 65 years from three provinces in Cambodia with varying levels of artemisinin resistance.

«RNAi is very promising as a therapy, but the efficacy of the treatment declines over time with each new cell division,» Jose said.

Prof Fortunato Ciardiello from Seconda Università degli Studi di Napoli, Italy, presented results from the CAPRI - Goim study on the efficacy of cetuximab plus FOLFOX chemotherapy as second - line treatment for patients with mCRC that progressed following FOLFIRI chemotherapy and cetuximab.

«All endpoints of efficacy and tolerability favoured treatment with pembrolizumab, suggesting it should become one standard of care for first line treatment of patients with advanced NSCLC and high PD - L1 expression.

Furthermore, the report accuses the British Homeopathic Association (BHA), which had submitted evidence to the panel, of cherry - picking, and even, in one case actively misrepresenting, research into the treatment (a famous study that concluded its findings were «compatible with the notion that the clinical effects of homeopathy are placebo effects» was cited by the BHA as evidence of the treatment's efficacy.)

A clinical trial investigating a treatment for blindness is under way this winter to evaluate the safety and efficacy of replacing diseased eye cells with stem cells.

«Additional studies should certainly be considered, but we hope that medical professionals will consider the positive potential of honey as a treatment given the lack of proven efficacy, expense and potential for adverse effects associated with the use of DM,» said lead study author Ian Paul, a pediatrician and associate professor of pediatrics.

«I believe we're about to see a whole new wave of treatments with less toxicity and more efficacy,» says Christian Ottensmeier of the University of Southampton, UK.

«The distinct neural markers associated with cognitive performance and GWI revealed in our study can be useful for future research to objectively measure the efficacy of treatments for GWI as well as other brain disorders related to the same neurotransmitter system, like Alzheimer's disease.»

A total of 347 patients (155 treated with vitamin E, 192 not treated with vitamin E) were included in the analysis which compared data from three clinical trials that investigated the efficacy and safety of vitamin E as a treatment for NASH: the PIVENS, TONIC and FLINT trials.

After the success of a new drug treatment in adults with hepatitis C infection, a Saint Louis University pediatric researcher is testing the safety and efficacy of the medications in children.

He also believes that additional research — possibly randomized, prospective studies — should be done to compare the safety and efficacy of PAE with other commonly performed BPH treatments.

This visual abstract depicts how Wei et al. utilize single - cell phosphoproteomic analysis of patient derived glioblastoma models to identify shifts in signaling coordination following short - term treatment with kinase inhibitors, which facilitates the design of combination therapy approaches with reduced resistance and improved efficacy.

The results from our new study suggest that entinostat may enhance the anti-tumor efficacy of PD - 1 targeted therapy through MDSC targeting, potentially providing an effective combination treatment approach for patients with solid tumors, including lung and renal cell carcinoma.»

Strollo led a large study of the new treatment, a yearlong safety and efficacy trial involving 126 people with moderate to severe obstructive apnea.

As the next step for this line of research, the investigators plan to expand to a larger prospective multicenter trial to further investigate the efficacy of the treatment in a larger sample of patients with dry AMD.

Researchers at Massachusetts Eye and Ear / Harvard Medical School and the University of Crete have conducted a phase I / II clinical trial investigating the efficacy of statins (cholesterol - lowering medications) for the treatment of patients with the dry form of age - related macular degeneration (AMD)-- the leading cause of blindness in the developed world.

In this trial, we demonstrated the safety and efficacy of a medication that will allow children with severe hemophilia A to be treated with a safe and effective medicine but with a reduced burden of the treatment.»

Researchers explained that this difference may be due, in part, to a selection bias where healthier patients were treated with surgery, and they underscored the need for a controlled clinical trial with matched patients receiving each treatment first - line to compare the efficacy of these therapies.

Theoretically, this precise molecular characterization of human disease will allow us to understand the basis for disease susceptibility and environmental influence; to offer an explanation for the different phenotypic manifestations of the same disease; to define disease prognosis with greater accuracy; and to refine and, ideally, individualize disease treatment for optimal therapeutic efficacy.

Adam R. Glassman, M.S., of the Jaeb Center for Health Research, Tampa, Fla., and colleagues examined the incremental cost - effectiveness ratios (ICERs) of aflibercept, bevacizumab, and ranibizumab for the treatment of DME with an analysis of efficacy, safety, and resource utilization data at 1 - year follow - up from the Diabetic Retinopathy Clinical Research (DRCR) Network Comparative Effectiveness Trial.

«Linking the navigation capability with these new results would allow therapeutics to be delivered directly to a specific site of the brain, potentially improving significantly the efficacy of the treatment while avoiding systemic circulation of toxic agents that affect healthy tissues and organs,» Carret added.

«To preserve patient access to this treatment option, and given the scale that we've reached, demonstrating the safety and efficacy of fecal transplantation through adequate and well - controlled clinical trials is the right thing to do,» explained Carolyn Edelstein, OpenBiome's director of Outreach and Public Affairs, in an op - ed published earlier today with the Fecal Transplant Foundation.

A Phase III, Open Label, Randomized Study to Assess the Efficacy and Safety of Olaparib (Lynparza) versus Enzalutamide or Abiraterone Acetate in Men with Metastatic Castration - Resistant Prostate Cancer who have Failed Prior Treatment with a New Hormonal Agent and have Homologous Recombination Repair Gene Mutations.

Along with our nonprofit partners, this program aims to collect, organize, and validate massive amounts of data generated by clinical trials across our global trial network sites in order to generate novel insights into biomarkers for safety and efficacy, novel treatment strategies, and personalization of treatment regimens.

Combination with gamma - secretase inhibitor prolongs treatment efficacy of BRAF inhibitor in BRAF - mutated melanoma cells.

Efficacy of intranasal Bevacizumab (Avastin) treatment in patients with hereditary hemorrhagic telangiectasia - associated epistaxis.

In line with the objectives of the International Rare Disease Research Consortium (IRDiRC), we aim to develop novel tools that will allow to make more accurate diagnoses, predict the disease course and the efficacy of available treatments, and help developing new and better therapies for rare kidney diseases.

Understanding this interaction will lead to targeted treatment «block the interaction» rather than the non-specific dampening of inflammation such as by corticosteroids with its many well - documented side effects and limited efficacy.»

This research project aims to establish the feasibility, safety, and potential efficacy of NAc DBS in 8 patients with a chronic, treatment refractory heroin and / or cocaine addiction.

Conversely, they have found that interfering with survivin expression in tumor cells is sufficient to trigger apoptosis, to enhance the efficacy of conventional anti-tumor treatment, and to exert potent anti-tumor activity in vivo.

The treatment protocol, the modified Story Memory Technique © (mSMT), was found to improve memory in adults with moderate to severe TBI, providing the first Class I evidence for the efficacy of this intervention in the TBI population.

Finally, we know that treatment early in the disease course is associated with improved efficacy of drugs and better outcomes, such as reduced risk for surgery.

Antagonistic analogs of growth hormone - releasing hormone increase the efficacy of treatment of triple negative breast cancer in nude mice with doxorubicin; A preclinical study

ERK1 / 2 inhibition increases antiestrogen treatment efficacy by interfering with hypoxia - induced downregulation of ERalpha: a combination therapy potentially targeting hypoxic and dormant tumor cells

«Immune checkpoint inhibitors, including PD - 1 and PD - L1 inhibitors, have provided meaningful clinical benefits for patients with cancer; however, novel immunotherapy combination treatments are needed to improve efficacy with limited additive toxicity,» said Aung Naing, MD, FACP, associate professor, Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston.

A study published in JAMA Dermatology investigated the efficacy of aromatherapy in the treatment of patients with alopecia areata.

For a legitimate place where to get legal injectable HGH for sale online, you should contact a medical facility with the sole practice of hormone replacement therapy, where you will not only get safe and high - quality medicine, but you will also receive a full treatment program that includes the monitoring of treatment by qualified medical personnel (yet another means of ensuring both safety and efficacy).

[6] One of the clearest benefits of exercise for prostate cancer is its efficacy for improving many of the adverse effects associated with treatment.

Efficacy of carnitine in the treatment of children with attention - deficit hyperactivity disorder.

In 2010, The University of Texas MD Anderson Cancer Center received more than $ 4.5 million — one of the largest yoga - related grants ever — from the National Institutes of Health's National Cancer Institute to support an ongoing study of the efficacy of yoga as part of a treatment program for women with breast cancer.

, Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: A six - week placebo - controlled, double - blind, multicentre trial, 2003

A combination approach beginning with microdermabrasion and followed by a light peel to boost and compliment the efficacy of both treatments.