Sentences with phrase «efficacy studies using»

The laboratory's Oncology Preclinical Services team, which offers preclinical efficacy studies using PDX and other models, including humanized (hu)- NSG mice, is also under his direction.

Not exact matches

Instead, it will conduct a Phase 1b / 2a study that will use «an improved cell processing technique to hopefully improve efficacy,» Fein noted.

Dreweke pointed to a study detailing the increased use of long - acting reversible contraceptives (such as IUDs and implants) among teens; although the study was only conducted among women who already used contraception, the efficacy of longer - acting contraceptives is higher than those of other birth control methods.

The group also cited that the application for Direct Use would subject unknowing communities to feeding studies in order to ascertain efficacy of Golden Rice.

Although caffeine is the most common stimulant in these drinks, many other stimulants are used without any studies to support their efficacy or safety.

They have a vested interest in publishing studies that promote the use of their medications and failing to publish study results that call the efficacy or safety of their drugs into question.

In 2001, a Swiss study was conducted to investigate the efficacy of using compression stockings during pregnancy as a method of preventing varicose veins.

In the early 1930s the number of studies on introducing solids to infants increased significantly, and the use and efficacy of commercially prepared canned baby food was integral to this research and the debate.

The brochures contain information about toxicology, pharmacology, and animal safety studies used to determine the potential risk a particular therapy may pose to humans, but they also include efficacy studies done in animal models to demonstrate a therapy's potential benefit.

The five types of cancers analyzed in this study have screening methods that allow for detection at an early stage, though in some instances, debate remains over efficacy and appropriate use: mammography for breast cancer, colonoscopy for colorectal cancer, Pap smear and / or HPV test for cervical cancer, spiral computed tomography or CT for lung cancer, and PSA test for prostate cancer.

The study chronicles the use of Vasalgel ™ in groups of rhesus macaques — confirming previous preclinical findings in rabbits on the efficacy of the new device and offering a new tool to colony managers.

Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of drug candidates against cancer stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.

The multicenter study, led by Scripps Clinic orthopedic surgeon Clifford Colwell, MD evaluated the efficacy of a mobile compression device that is small and portable enough for patients to use at home for 10 days or longer after joint replacement surgery.

«The next steps are to develop tau - lowering therapeutics that could be used in humans and to evaluate their safety and efficacy in preclinical studies,» said Dr. Mucke, «objectives we are pursuing actively.»

But a new study casts doubt on biochar's efficacy, finding that using it only improves crop growth in the tropics, with no yield benefit at all in the temperate zone.

«Additional studies should certainly be considered, but we hope that medical professionals will consider the positive potential of honey as a treatment given the lack of proven efficacy, expense and potential for adverse effects associated with the use of DM,» said lead study author Ian Paul, a pediatrician and associate professor of pediatrics.

In the next study, we plan to follow up using a blood - based liquid biopsy to determine in real - time the efficacy of the treatment,» said Professor John H. Lee, MD, Department of Cancer Research, Sanford Health, and Principal Investigator of the study.

«When each of the clinicians or clinical teams that have been using ZMapp release their data, we'll get a better sense of maybe the efficacy, but even then, it's hard because it's not really a designed study,» Kobinger said.

Connie Celum, an epidemiologist at the University of Washington, Seattle, who ran a large oral PrEP study with Truvada that had 73 % efficacy, says it will be important to compare VOICE and CAPRISA 004 for differences in sexual behaviors, sexually transmitted infections, cervicovaginal inflammation, and contraceptive use.

I mean, if there is existing literature studies looking at those plants where they found active compound [s], I definitely will use that, but first I am trying to show that there is a pattern — that if you do some math and try to synthesize all this information about the different plants being used in different cultures for different diseases, and using the evolutionary relationships of the plants, the cultures and the diseases to sort of merge it all together and have these equations spit out a sort of potential efficacy — our best guess of what the efficacy of this plant is.

«Future research will focus on optimizing the candidate therapies discovered by our team in this study as well as developing biomarkers that can be used to test the efficacy of other potentially promising drugs,» says Dr. Rothstein

«We are exploring alternative directions for developing this compound, including potential use of the animal efficacy rule,» Cihlar said, referring to a regulatory mechanism under which the U.S. Food and Drug Administration may consider efficacy findings from adequate and well - controlled animal studies of a drug in cases where it is not feasible or ethical to conduct human trials.

Next to this, WBVR offers the use of its infrastructure to perform immunogenicity and efficacy studies for newly developed vaccines.

A Phase I / II, Open - label, Multi-center Study of the Safety and Efficacy of IMCgp100 using the Intra-patient Escalation Dosing Regimen in Patients with Advanced Uveal Melanoma

Kessler Foundation has been using Ekso Bionics» exoskeleton for clinical research in patients with spinal cord injury since October 2011 and recently acquired a second device to study utility and efficacy specifically for stroke survivors.

With the availability of this remarkable tool, it's hard to understand why so many researchers continue to use grain - based chow diets in nutrition studies and even, as we shall see, in studies that are not necessarily nutrition - oriented, such as drug and compound efficacy studies, or behavioral studies.

«I think a lot of our success comes from delivering the intervention using home - based approaches and building up people's self - efficacy so that they rely on themselves,» said study lead author Wendy Demark - Wahnefried, PhD, RD, of the University of Alabama at Birmingham Comprehensive Cancer Center.

Using data from the AHRQ report, the Institute for Clinical and Economic Review (ICER, 2011) conducted a cost - effectiveness modeling study, assuming that transcranial electrical stimulation and electroconvulsive therapy have equivalent efficacy.

Evaluating the efficacy of repurposed small molecule inhibitors in treating filariasis using preclinical and clinical studies

Recently, Dr. Wapner led a multicenter study evaluating the accuracy, efficacy, and clinical advantages of prenatal diagnosis using microarray analysis.

Although the efficacy in the Thai study was not high enough to warrant the vaccine's use as a public health tool, the results are helping scientists develop more effective HIV vaccine candidates.

BOSTON, Mass. — Emulate, Inc. announced today that it has formed a strategic partnership with F Hoffman La - Roche AG (Roche) that will use Emulate's Human Emulation System across R&D programs to enable more human - relevant studies that will lead to earlier and better prediction of safety and efficacy of drug candidates.

So, regulators and drug developers are looking at ways to import data collected in early studies — which are used to initially assess drug safety and efficacy — into the Phase 3 studies that the FDA uses to determine whether drugs should make it onto the market.

In the meantime, some patients will continue to use marijuana even though large studies havent tested its safety and efficacy.

Stress resistance has not been assessed however and so the biological relevance of this finding is currently unknown.32 Several IER trials (75 - 85 % ER on restricted days) in overweight / obese populations have reported reductions in various markers of oxidative stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directions

The ketogenic diet is a high fat, restricted carbohydrate regime that has been used since the 1920s; efficacy in epilepsy has been demonstrated in many studies including a randomised controlled trial (3).

Low - carbohydrate advocates are masters of documenting the efficacy of their philosophy using studies with small population sizes conducted over short time periods — often over weeks or months.

In this article we will review creatines benefits, some important studies to back its efficacy, its broader applications, and the populations who will benefit most from its use.

This species has a history of use in traditional Chinese medicine and although there have been anecdotal reports of benefits, there have been no clinical controlled studies to test the efficacy of this herb (herb, here referring to a general term that may be either a plant, root, mold, and in this case, a parasite.)

These options use a mix of real food ingredients and ancient herbs, which incidentally have been highly studied for efficacy with proven results.

As far as brushing goes, by all means, do it when you feel like it... we recommend using a Bass brush (or) a chewing stick just like our early ancestors did which shows parallel, or even greater efficacy, as compared to standard brushing (see study).

Angie also partnered in 2016 on the first - ever medical study using the Autoimmune Protocol with Scripps Clinic in San Diego, entitled, «Efficacy of the Autoimmune Protocol Diet for Inflammatory Bowel Disease.»

According to Lise Alschuler, author of the Definitive Guide To Cancer: An Integrative Approach to Prevention, Treatment, and Healing, studies on flax lignans demonstrate safety and efficacy in their use against breast cancer, «inhibiting the growth of human estrogen - dependent breast cancer cells in mice and strengthening the tumor - inhibitory effect of tamoxifen».

Clinical Outcomes of a Diagnostic and Treatment Protocol in Allergy / sensitivity Patients Alternative Medicine Review 2001 (Apr); 6 (2): 188 — 202 ~ FULL TEXT This level II outcome study was conducted to examine the efficacy and toxicity of a diagnostic and treatment protocol using electrodermal screening (EDS) in allergy / sensitivity patients.

Because of these previously established associations, self efficacy was utilized as a co-variate in the present study when assessing the relationship between cell phone use and cardiorespiratory fitness.

This data suggests a different effect of ketosis on glucose homeostasis in diabetic and non-diabetic individuals.21 Other studies support the long - term efficacy of ketogenic diets in managing complications of T2D.36, 37 Although significant reductions in fat mass often results when individuals restrict carbohydrate, the improvements in glycaemic control, haemoglobin A1c and lipid markers, as well as reduced use or withdrawal of insulin and other medications in many cases, occurs before significant weight loss occurs.

Further, a review of other studies on LAM found that many women are not meeting the above criteria, and therefore, not using this method of NFP correctly, which, of course, decreases efficacy.

Cellulose is often used as the placebo in studies designed to test the efficacy of fibers on decreasing serum cholesterol concentrations.

I am currently involved in an interesting research effort to look deeper into how these kinds of efficacy studies are used, which will culminate in a symposium this coming May.

Because of this converging scientific consensus, the No Child Left Behind Act requires school districts to demonstrate that they are using reading programs that have been tested for their efficacy through scientific studies in order to qualify for federal reading funds.