Sentences with phrase «efficacy trial model»

The GP practices were involved in ensuring the study not only had access to specific COPD patients but also that the usual clinical care provided by the practices was built into the trials — the study was therefore rooted in a real clinical environment unlike tradition efficacy trial model.

«New research method questions traditional efficacy trial model.»

Not exact matches

«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.

«Right now, one of the biggest areas of failure is in phase II trials, when you get to those places where you're looking for efficacy and you suddenly discover that the compound that worked great in your animal model doesn't do much in humans,» he says.

It is currently being evaluated for safety and efficacy in preclinical models with a Phase I trial expected to begin in 2019.

Overall, SR - Tiget represents a multi-disciplinary research environment, which provides a unique blend of scientific expertise in the development of innovative gene and cell therapy strategies, access to relevant preclinical models to evaluate their efficacy and safety, as well as competence in conducting early phase clinical trials.

In addition, the Fletcher group investigates immunity using the mouse model and aims to develop animal models of TB disease better able to predict TB vaccine efficacy in clinical trials.

Model F: Standard immune competent mouse model for protective efficacy Model G: GMP, adjuvant and formulation studies Model H: Comparative phase 1 clinical Model F: Standard immune competent mouse model for protective efficacy Model G: GMP, adjuvant and formulation studies Model H: Comparative phase 1 clinical model for protective efficacy Model G: GMP, adjuvant and formulation studies Model H: Comparative phase 1 clinical Model G: GMP, adjuvant and formulation studies Model H: Comparative phase 1 clinical Model H: Comparative phase 1 clinical trial

Subgroup analyses: We will examine whether there is evidence that the intervention effect is modified for subgroups within the trial participants using tests of interaction between intervention and child and family factors as follows: parity (first - born vs other), antenatal risks (2 vs 3 or more risk factors at screening), maternal mental health at baseline (high vs low score) 18, 62, 63 and self - efficacy at baseline (poor vs normal mastery) 35 using the regression models described above with additional terms for interaction between subgroup and trial arm.

For bipolar disorder, a number of models are in development, including MoodSwings (http://www.moodswings.net.au).46 It is expected that, if formal trials demonstrate efficacy, these programs will become widely used due to their cost - effectiveness, convenience and reach.