In fact, the team showed that the fragment approach worked better than combining ADEPs with reserpine, a well - known
efflux inhibitor.
Not exact matches
Saint Louis University researchers then synthesized structural analogs of the discovered
efflux pump
inhibitors and identified properties essential for their activities.
They plan to leverage a recently awarded Innovative and Novel Computational Impact on Theory and Experiment (INCITE) allocation from DOE to perform larger simulations on the Titan supercomputer to gain deeper understanding of how bacterial
efflux pumps function, identify more potent
efflux pump
inhibitors and optimize the best antibiotic - plus -
inhibitor combinations to make them suitable for clinical trials.
Montelukast is a potent and durable
inhibitor of multidrug resistance protein 2 (MRP2)- mediated
efflux of taxol and saquinavir.