Sentences with phrase «efflux out of the cell»

Furthermore, if an agent is able to penetrate one or both of these membranes, it is often subject to rapid efflux out of the cell by numerous broadly acting efflux pumps - rendering the agent ineffective.

Not exact matches

For example, up - regulated influx transporters (OCT3 and OCTN1) localized at the apical membranes of Sertoli cells could mediate the transport of the drug compound 9 from the lumen into the basolateral compartment of Sertoli cells, where the up - regulated efflux transporters (ABCB1 / p - glycoprotein, ABCB8, ABCB9, ABCC5, and ABCC10) could then transport the drug out of Sertoli cells against a concentration gradient, resulting in enhanced efficiency of recovery upon cessation of treatment.

Efflux pumps are surface proteins that prevent antimicrobial drugs from getting a foothold in a bacterial cell by identifying and pumping them out of the cell.