We examined the effects of treatment on tumor growth, drug resistance, GHRH - R levels, expression of MDR1 and Nanog, and
efflux pump activity.
«As a first in this field, we proposed the approach of essentially «screwing up» the
efflux pump's protein assembly, and this led to the discovery of molecules with a new type of antibacterial
activity,» said co-author Jeremy Smith, who serves as a UT - ORNL Governor's Chair and director of the UT - ORNL Center for Molecular Biophysics.