Application of these computational techniques to the multitude of
efflux pumps found in different Gram - negative pathogens should allow scientists to elucidate if general mechanisms are shared among different pumps or are pump - specific.
Not exact matches
The
findings, published November 28 in Scientific Reports, offer a better understanding of the motions and functions of
efflux pumps.
The researchers
found four new chemicals that seek out and disrupt bacterial proteins called «
efflux pumps,» known to be a major cause of antibiotic resistance.
Specifically, these investigators showed that the levels of several
efflux (P - glycoprotein, MRP1, ABCG1) and influx (SLC15A1)
pumps were
found to increase by several fold within hours of adjudin treatment (27).