Sentences with phrase «efflux pumps in»

Another supplied a plant compound (diosmetin) known to disable efflux pumps in other bacteria.

New supercomputer simulations have revealed the role of transport proteins called efflux pumps in creating drug - resistance in bacteria, research that could lead to improving the drugs» effectiveness against life - threatening diseases and restoring the efficacy of defunct antibiotics.

Recognizing this, He and his research team developed a way to reduce the amount of chemical energy — adenosine triphosphate (ATP)-- available to the efflux pumps in cancer cells.

The Solution: Working with pathogenic bacteria would be far too dangerous in a school setting, so Delgado focused on disabling an efflux pump in the common bacterium E. coli.

Not exact matches

The findings, published November 28 in Scientific Reports, offer a better understanding of the motions and functions of efflux pumps.

One type of efflux pump, which until recently had only been studied in parts, was recently modeled in its entirety and simulated using supercomputers at Los Alamos National Laboratory.

Application of these computational techniques to the multitude of efflux pumps found in different Gram - negative pathogens should allow scientists to elucidate if general mechanisms are shared among different pumps or are pump - specific.

«We study a lot of efflux pumps to understand antibiotic resistance,» said Yu, an Iowa State professor with appointments in physics and astronomy; chemistry; biochemistry, biophysics and molecular biology; and the U.S. Department of Energy's Ames Laboratory.

One trick used by some bacteria is to eject antibiotics through so - called efflux pumps embedded in their cellular membranes.

Some coded for multi-drug efflux pumps, which are multi-drug resistance mechanisms embedded in the bacterial membrane that pump specific antibiotics out of the bacteria.

Heterogeneity in a bacterial population that arises through a mechanism of biased partitioning of drug efflux pumps, as we identified in our study, could be a stepping - stone on the path of bacterial populations towards antibiotic resistance.»

The team focused on one efflux pump protein, known as AcrA, which connects two other proteins in a tunnel shape through the bacterial cell envelope.

«As a first in this field, we proposed the approach of essentially «screwing up» the efflux pump's protein assembly, and this led to the discovery of molecules with a new type of antibacterial activity,» said co-author Jeremy Smith, who serves as a UT - ORNL Governor's Chair and director of the UT - ORNL Center for Molecular Biophysics.

This picture was suddenly complicated in 1999, when Gerd Jürgens and his colleagues at the University of Tübingen in Germany discovered a mutant of the model plant Arabidopsis with efflux pumps everywhere in the cell.

Similarly in C. neoformans, Chr 1 disomy confers azole resistance because this chromosome harbors ERG11 and AFR1 (which encodes the major azole efflux pump) and aneuploidy can also influence the virulence of this pathogen [16], [20], [21].

Efflux pumps are surface proteins that prevent antimicrobial drugs from getting a foothold in a bacterial cell by identifying and pumping them out of the cell.

Additionally, cells treated with MIA - 602 showed a significant increases in Calcein dye retention, indicating that efflux pump function was reduced.

The genes MDR1 and NANOG, both involved in the regulation and expression of efflux pump mechanisms, were significantly suppressed.

: This study evaluated the effects of an antagonistic analog of growth hormone - releasing hormone, MIA - 602, on tumor growth, response to doxorubicin, expression of drug resistance genes, and efflux pump function in human triple negative breast cancers.

Introduction: This study evaluated the effects of an antagonistic analog of growth hormone - releasing hormone, MIA - 602, on tumor growth, response to doxorubicin, expression of drug resistance genes, and efflux pump function in human triple negative breast cancers.

In - vitro cell culture assays were used to analyze the effect of MIA - 602 on efflux pump function.

MIA - 602 also suppressed efflux pump function in both cell lines.

decreases drug resistance in Lyme by blocking efflux pumps that remove antibiotics from germs,

Germs in biofilms use efflux pumps that flush antibiotics out.

The hole in the canoe is the antimicrobial or the antibiotics coming in, and then, the efflux pumps are bailing that water out.