Compared to dietary omega - 6 fatty acids, which generally give rise to more inflammatory thromboxanes, prostaglandins, and leukotrienes, omega - 3 fatty acids are metabolized into less inflammatory
eicosanoid signaling molecules.
Long chain ω - 3 (EPA moreso than DHA) fats are generally thought to reduce inflammatory signalling because they compete with the ω - 6 fat arachidonic acid for conversion to
eicosanoid signaling molecules.
Not exact matches
CYP - 13A12 promotes oxidation of polyunsaturated fatty acids into
eicosanoids,
signaling molecules that can strongly affect inflammatory pain and ischemia - reperfusion injury responses in mammals.
Some cytochrome p450 enzymes act on polyunsaturated fatty acids to make cellular
signaling molecules known as
eicosanoids.
Eicosanoid Activation of Protein Kinase C ϵ INVOLVEMENT IN GROWTH CONE REPELLENT
SIGNALING.
Felder et al. «Anandamide, An Endogenous Cannabimimetic
Eicosanoid, Binds to the Cloned Human Cannabinoid Receptor and Stimulates Receptor - Mediated
Signal Transduction», Proc.
It inhibits the production of
eicosanoids, which are one of the precursors in the body's
signaling pathway for inflammation.
As I illustrated above, arachidonic acid is processed by the enzyme cyclooxygenase (COX) to produce pro-inflammatory
signaling molecules called
eicosanoids, including leukotrienes, prostaglandins, and thromboxanes.
At a mechanistic level, curcumin mitigates inflammation by inhibiting an array of pro-inflammatory
signaling molecules, such as the
eicosanoids known as leukotrienes, thromboxanes, and prostaglandins, which elicit deleterious effects ranging from pain to blood clotting to airway constriction (Chainani, 2003).
This competition effect is troubling because among the many uses the body has for omega - 3s and -6 s, it converts them to
signaling molecules called
eicosanoids, which promote unhealthy amounts inflammation, blood coagulation, and blood vessel constriction.
Although it can be part of a complicated picture, DGLA's own
eicosanoids (
signaling lipids) can often out - compete AA's generally pro-inflammatory
eicosanoids.
Both are required for complete optimal metabolic function and their function in the body is similar in that they are both used to generate a wide range
eicosanoids, the technical term for the aforementioned «
signal molecules.»
As I mentioned above, Omega 3's and Omega 6's «compete» in the body for the enzymes that convert them into the
signal molecules
eicosanoids.
The drugs have similar effects to those of steroids, including depressing
eicosanoids that transmit
signals to the brain.