In his postdoctoral training at Metrohealth Medical Center, Duke University Medical Center, and Mt. Sinai Medical Center, he has been interested in the maintenance of
electrical function in the heart during embryonic development and in heart failure models.
This information is used to understand the role of
electrical function in human brain disorders.
Not exact matches
Veronica has been involved
in safety - related job
functions and
in the medical industry
in Austin and surrounding areas for several years, being employed by an electric cooperative, where part of her role was teaching children
electrical safety, and then being employed by a major urgent care facility.
It has been particularly difficult to measure changes
in electrical functions of cells grown within Organ Chips that are normally electrically active, such as neuronal cells
in the brain or beating heart cells, both during their differentiation and
in response to drugs.
More than 2.5 million Americans have epilepsy, a disorder
in which abnormal
electrical impulses
in the brain affect a variety of mental and physical
functions.
Since the EU banned lead (see Uncovering the hazards
in our electronic gadgets) from
electrical devices
in 2006, scientists and manufacturers have been scrambling to find alternatives to key materials that depend on the toxic metal for their
function.
«Such an atomically thin device could have dual
functions, serving simultaneously as optical or
electrical transistors, and hence broaden the functionalities of the electronics used
in our daily lives,» said Wang.
«Our goal
in the project was to close the gap
in knowledge that exists on role of serotonin
in the brain cortex, particularly as it concerns brain circuitry, its
electrical activity and
function,» said Roberto Fernández Galán, PhD, Assistant Professor
in the Department of Neurosciences at Case Western Reserve University School of Medicine.
Unfortunately,
electrical stimulators are little effective
in restoring larynx
function, «because there are different muscles with opposite
function close together,» explains Dr. Tobias van Bremen, an ear, nose and throat doctor and one of the co-authors of the study.
Some of the pinpointed genes are known to be involved
in the
function of synapses, tiny connectors that allow brain cells to communicate with each other through
electrical and chemical signals.
In previous work Tufts University developmental biologist Michael Levin found that patterns of electrical potentials in the earliest stages of an embryo's development can direct how an animal's body grows, and that manipulating those potentials can cause a creature to sprout extra limbs, tails or functioning eye
In previous work Tufts University developmental biologist Michael Levin found that patterns of
electrical potentials
in the earliest stages of an embryo's development can direct how an animal's body grows, and that manipulating those potentials can cause a creature to sprout extra limbs, tails or functioning eye
in the earliest stages of an embryo's development can direct how an animal's body grows, and that manipulating those potentials can cause a creature to sprout extra limbs, tails or
functioning eyes.
«What we've achieved here is a new way of creating electromagnetic devices that achieve certain
functions that conventionally seemed impossible to do,» said Prem Kumar, professor of
electrical engineering and computer science
in McCormick and of physics and astronomy
in the Weinberg College of Arts and Sciences.
They do this by looking at the
electrical activity of individual neurons
in a live mammal brain to build a bigger picture of its
function as a whole organ.
Much more work is required to determine whether
electrical modulation of memory circuits could be used as a therapeutic strategy to enhance
function in patients with memory disturbances.
But what is it about the structure and
function of each and every neuron, and the way they network together, that give rise to these
electrical signals measured
in a mammalian brain?
A new study authored by Marc Schieber, M.D., Ph.D., and Kevin Mazurek, Ph.D. with the University of Rochester Medical Center Department of Neurology and the Del Monte Institute for Neuroscience, which appears
in the journal Neuron, shows that very low levels of
electrical stimulation delivered directly to an area of the brain responsible for motor
function can instruct an appropriate response or action, essentially replacing the signals we would normally receive from the parts of the brain that process what we hear, see, and feel.
Dr. Forrest conducts mobility research at Kessler Foundation, where
in addition to Ekso, she studies the effectiveness of activity based therapies for recovery of
function including
electrical stimulation, and the LokomatPro v6 (Hocoma), a robotic treadmill training device.
g (acceleration due to gravity) G (gravitational constant) G star G1.9 +0.3 gabbro Gabor, Dennis (1900 — 1979) Gabriel's Horn Gacrux (Gamma Crucis) gadolinium Gagarin, Yuri Alexeyevich (1934 — 1968) Gagarin Cosmonaut Training Center GAIA Gaia Hypothesis galactic anticenter galactic bulge galactic center Galactic Club galactic coordinates galactic disk galactic empire galactic equator galactic habitable zone galactic halo galactic magnetic field galactic noise galactic plane galactic rotation galactose Galatea GALAXIES galaxy galaxy cannibalism galaxy classification galaxy formation galaxy interaction galaxy merger Galaxy, The Galaxy satellite series Gale Crater Galen (c. AD 129 — c. 216) galena GALEX (Galaxy Evolution Explorer) Galilean satellites Galilean telescope Galileo (Galilei, Galileo)(1564 — 1642) Galileo (spacecraft) Galileo Europa Mission (GEM) Galileo satellite navigation system gall gall bladder Galle, Johann Gottfried (1812 — 1910) gallic acid gallium gallon gallstone Galois, Évariste (1811 — 1832) Galois theory Galton, Francis (1822 — 1911) Galvani, Luigi (1737 — 1798) galvanizing galvanometer game game theory GAMES AND PUZZLES gamete gametophyte Gamma (Soviet orbiting telescope) Gamma Cassiopeiae Gamma Cassiopeiae star gamma
function gamma globulin gamma rays Gamma Velorum gamma - ray burst gamma - ray satellites Gamow, George (1904 — 1968) ganglion gangrene Ganswindt, Hermann (1856 — 1934) Ganymede «garbage theory», of the origin of life Gardner, Martin (1914 — 2010) Garneau, Marc (1949 ---RRB- garnet Garnet Star (Mu Cephei) Garnet Star Nebula (IC 1396) garnierite Garriott, Owen K. (1930 ---RRB- Garuda gas gas chromatography gas constant gas giant gas laws gas - bounded nebula gaseous nebula gaseous propellant gaseous - propellant rocket engine gasoline Gaspra (minor planet 951) Gassendi, Pierre (1592 — 1655) gastric juice gastrin gastrocnemius gastroenteritis gastrointestinal tract gastropod gastrulation Gatewood, George D. (1940 ---RRB- Gauer - Henry reflex gauge boson gauge theory gauss (unit) Gauss, Carl Friedrich (1777 — 1855) Gaussian distribution Gay - Lussac, Joseph Louis (1778 — 1850) GCOM (Global Change Observing Mission) Geber (c. 720 — 815) gegenschein Geiger, Hans Wilhelm (1882 — 1945) Geiger - Müller counter Giessler tube gel gelatin Gelfond's theorem Gell - Mann, Murray (1929 ---RRB- GEM «gemination,» of martian canals Geminga Gemini (constellation) Gemini Observatory Gemini Project Gemini - Titan II gemstone gene gene expression gene mapping gene pool gene therapy gene transfer General Catalogue of Variable Stars (GCVS) general precession general theory of relativity generation ship generator Genesis (inflatable orbiting module) Genesis (sample return probe) genetic code genetic counseling genetic disorder genetic drift genetic engineering genetic marker genetic material genetic pool genetic recombination genetics GENETICS AND HEREDITY Geneva Extrasolar Planet Search Program genome genome, interstellar transmission of genotype gentian violet genus geoboard geode geodesic geodesy geodesy satellites geodetic precession Geographos (minor planet 1620) geography GEOGRAPHY Geo - IK geologic time geology GEOLOGY AND PLANETARY SCIENCE geomagnetic field geomagnetic storm geometric mean geometric sequence geometry GEOMETRY geometry puzzles geophysics GEOS (Geodetic Earth Orbiting Satellite) Geosat geostationary orbit geosynchronous orbit geosynchronous / geostationary transfer orbit (GTO) geosyncline Geotail (satellite) geotropism germ germ cells Germain, Sophie (1776 — 1831) German Rocket Society germanium germination Gesner, Konrad von (1516 — 1565) gestation Get Off the Earth puzzle Gettier problem geyser g - force GFO (Geosat Follow - On) GFZ - 1 (GeoForschungsZentrum) ghost crater Ghost Head Nebula (NGC 2080) ghost image Ghost of Jupiter (NGC 3242) Giacconi, Riccardo (1931 ---RRB- Giacobini - Zinner, Comet (Comet 21P /) Giaever, Ivar (1929 ---RRB- giant branch Giant Magellan Telescope giant molecular cloud giant planet giant star Giant's Causeway Giauque, William Francis (1895 — 1982) gibberellins Gibbs, Josiah Willard (1839 — 1903) Gibbs free energy Gibson, Edward G. (1936 ---RRB- Gilbert, William (1544 — 1603) gilbert (unit) Gilbreath's conjecture gilding gill gill (unit) Gilruth, Robert R. (1913 — 2000) gilsonite gimbal Ginga ginkgo Giotto (ESA Halley probe) GIRD (Gruppa Isutcheniya Reaktivnovo Dvisheniya) girder glacial drift glacial groove glacier gland Glaser, Donald Arthur (1926 — 2013) Glashow, Sheldon (1932 ---RRB- glass GLAST (Gamma - ray Large Area Space Telescope) Glauber, Johann Rudolf (1607 — 1670) glaucoma glauconite Glenn, John Herschel, Jr. (1921 ---RRB- Glenn Research Center Glennan, T (homas) Keith (1905 — 1995) glenoid cavity glia glial cell glider Gliese 229B Gliese 581 Gliese 67 (HD 10307, HIP 7918) Gliese 710 (HD 168442, HIP 89825) Gliese 86 Gliese 876 Gliese Catalogue glioma glissette glitch Global Astrometric Interferometer for Astrophysics (GAIA) Global Oscillation Network Group (GONG) Globalstar globe Globigerina globular cluster globular proteins globule globulin globus pallidus GLOMR (Global Low Orbiting Message Relay) GLONASS (Global Navigation Satellite System) glossopharyngeal nerve Gloster E. 28/39 glottis glow - worm glucagon glucocorticoid glucose glucoside gluon Glushko, Valentin Petrovitch (1908 — 1989) glutamic acid glutamine gluten gluteus maximus glycerol glycine glycogen glycol glycolysis glycoprotein glycosidic bond glycosuria glyoxysome GMS (Geosynchronous Meteorological Satellite) GMT (Greenwich Mean Time) Gnathostomata gneiss Go Go, No - go goblet cell GOCE (Gravity field and steady - state Ocean Circulation Explorer) God Goddard, Robert Hutchings (1882 — 1945) Goddard Institute for Space Studies Goddard Space Flight Center Gödel, Kurt (1906 — 1978) Gödel universe Godwin, Francis (1562 — 1633) GOES (Geostationary Operational Environmental Satellite) goethite goiter gold Gold, Thomas (1920 — 2004) Goldbach conjecture golden ratio (phi) Goldin, Daniel Saul (1940 ---RRB- gold - leaf electroscope Goldstone Tracking Facility Golgi, Camillo (1844 — 1926) Golgi apparatus Golomb, Solomon W. (1932 — 2016) golygon GOMS (Geostationary Operational Meteorological Satellite) gonad gonadotrophin - releasing hormone gonadotrophins Gondwanaland Gonets goniatite goniometer gonorrhea Goodricke, John (1764 — 1786) googol Gordian Knot Gordon, Richard Francis, Jr. (1929 — 2017) Gore, John Ellard (1845 — 1910) gorge gorilla Gorizont Gott loop Goudsmit, Samuel Abraham (1902 — 1978) Gould, Benjamin Apthorp (1824 — 1896) Gould, Stephen Jay (1941 — 2002) Gould Belt gout governor GPS (Global Positioning System) Graaf, Regnier de (1641 — 1673) Graafian follicle GRAB graben GRACE (Gravity Recovery and Climate Experiment) graceful graph gradient Graham, Ronald (1935 ---RRB- Graham, Thomas (1805 — 1869) Graham's law of diffusion Graham's number GRAIL (Gravity Recovery and Interior Laboratory) grain (cereal) grain (unit) gram gram - atom Gramme, Zénobe Théophile (1826 — 1901) gramophone Gram's stain Gran Telescopio Canarias (GTC) Granat Grand Tour grand unified theory (GUT) Grandfather Paradox Granit, Ragnar Arthur (1900 — 1991) granite granulation granule granulocyte graph graph theory graphene graphite GRAPHS AND GRAPH THEORY graptolite grass grassland gravel graveyard orbit gravimeter gravimetric analysis Gravitational Biology Facility gravitational collapse gravitational constant (G) gravitational instability gravitational lens gravitational life gravitational lock gravitational microlensing GRAVITATIONAL PHYSICS gravitational slingshot effect gravitational waves graviton gravity gravity gradient gravity gradient stabilization Gravity Probe A Gravity Probe B gravity - assist gray (Gy) gray goo gray matter grazing - incidence telescope Great Annihilator Great Attractor great circle Great Comets Great Hercules Cluster (M13, NGC 6205) Great Monad Great Observatories Great Red Spot Great Rift (
in Milky Way) Great Rift Valley Great Square of Pegasus Great Wall greater omentum greatest elongation Green, George (1793 — 1841) Green, Nathaniel E. Green, Thomas Hill (1836 — 1882) green algae Green Bank Green Bank conference (1961) Green Bank Telescope green flash greenhouse effect greenhouse gases Green's theorem Greg, Percy (1836 — 1889) Gregorian calendar Grelling's paradox Griffith, George (1857 — 1906) Griffith Observatory Grignard, François Auguste Victor (1871 — 1935) Grignard reagent grike Grimaldi, Francesco Maria (1618 — 1663) Grissom, Virgil (1926 — 1967) grit gritstone Groom Lake Groombridge 34 Groombridge Catalogue gross ground,
electrical ground state ground - track group group theory GROUPS AND GROUP THEORY growing season growth growth hormone growth hormone - releasing hormone growth plate Grudge, Project Gruithuisen, Franz von Paula (1774 — 1852) Grus (constellation) Grus Quartet (NGC 7552, NGC 7582, NGC 7590, and NGC 7599) GSLV (Geosynchronous Satellite Launch Vehicle) g - suit G - type asteroid Guericke, Otto von (1602 — 1686) guanine Guiana Space Centre guidance, inertial Guide Star Catalog (GSC) guided missile guided missiles, postwar development Guillaume, Charles Édouard (1861 — 1938) Gulf Stream (ocean current) Gulfstream (jet plane) Gullstrand, Allvar (1862 — 1930) gum Gum Nebula gun metal gunpowder Gurwin Gusev Crater gut Gutenberg, Johann (c. 1400 — 1468) Guy, Richard Kenneth (1916 ---RRB- guyot Guzman Prize gymnosperm gynecology gynoecium gypsum gyrocompass gyrofrequency gyropilot gyroscope gyrostabilizer Gyulbudagian's Nebula (HH215)
«This study provides proof - of - concept experiments,
in large animal models, that a small, miniaturized device can be safely implanted
in the brain and provide miniaturized control of the
electrical activity and
function of single neurons or small groups of neurons.
For example, we are using
electrical spinal stimulation synchronized with residual muscle activity or movement
in order to produce lasting improvements
in hand and arm
function after spinal cord injury.
Susan Amara, USA - «Regulation of transporter
function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tran
function and trafficking by amphetamines, Structure -
function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tran
function relationships
in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of
Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular
function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tran
function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers
in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors
in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular
Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tran
Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors,
in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure,
function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tran
function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure,
function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tran
function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and
function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tran
function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure
function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tran
function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation
in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling
in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and
function of the ATP - binding cassette (ABC) tran
function of the ATP - binding cassette (ABC) transporters
To gain an understanding of how
electrical synapses specifically form between neurons, we are interested
in determining which gap junctions identified
in the reconstruction of the nervous system have UNC - 7 as a component, which other innexins contribute to these junctions, what determines specificity for forming complete channels, and how these gap junctions
function to direct information flow
in the nervous system.
Wilder Penfield was the first neurosurgeon to explore the neural locus of epilepsy at the same time as mapping behavioral / memory
functions of different brain regions through
electrical stimulation
in fully conscious patients.
Potassium is a mineral that is necessary for
electrical and cellular
functions in the body.
Sodium, chloride and potassium
function in your body as electrolytes, small particles that carry an
electrical charge.
These all help the nervous system
function by aiding
in conducting the
electrical signals they carry.
He has currently done some chiropractic adjustments to get me aligned properly and has me working on the ARP trainer, which is a type of machine that sends
electrical currents through your shut - off muscles
in order to get them to
function properly.
This nutrient helps maintain
electrical gradients
in the body's cells and serves various important
functions.
* Using ConcenTrace every helps maintain healthy energy levels
in your body by providing your body's entire
electrical system with the minerals it needs to
function properly.
Year 4 Science Assessments Objectives covered: Recognise that living things can be grouped
in a variety of ways Explore and use classification keys to help group, identify and name a variety of living things
in their local and wider environment Recognise that environments can change and that this can sometimes pose dangers to living things Describe the simple
functions of the basic parts of the digestive system
in humans Identify the different types of teeth
in humans and their simple
functions Construct and interpret a variety of food chains, identifying producers, predators and prey Compare and group materials together, according to whether they are solids, liquids or gases Observe that some materials change state when they are heated or cooled, and measure or research the temperature at which this happens
in degrees Celsius (°C) Identify the part played by evaporation and condensation
in the water cycle and associate the rate of evaporation with temperature Identify how sounds are made, associating some of them with something vibrating Recognise that vibrations from sounds travel through a medium to the ear Find patterns between the pitch of a sound and features of the object that produced it Find patterns between the volume of a sound and the strength of the vibrations that produced it Recognise that sounds get fainter as the distance from the sound source increases Identify common appliances that run on electricity Construct a simple series
electrical circuit, identifying and naming its basic parts, including cells, wires, bulbs, switches and buzzers Identify whether or not a lamp will light
in a simple series circuit, based on whether or not the lamp is part of a complete loop with a battery Recognise that a switch opens and closes a circuit and associate this with whether or not a lamp lights
in a simple series circuit Recognise some common conductors and insulators, and associate metals with being good conductors
Also, it apparently can't be a Land Rover without some
electrical gremlin:
in this case, the auto - up
function for the driver's window was inoperable (the other three windows worked as designed)...
Using a relay strip from TinySine, a Bluetooth Bee, a 12V - 5V converter, and a switch for disabling the system
in case of an emergency, he tied the iPad mini into the car's
electrical systems and can now use it to control almost every
function of the car.
In my experience with automotive
electrical, it can be very tricky to figure out, but the first most important thing is ensuring that you have a fully charged,
functioning, battery.
Over time, increased resistance at the taillight
electrical contact points may cause damage to the ground terminal and housing of the connector resulting
in an intermittent or permanent loss of functionality of one or more rear lamp
functions (tail, brake, turn - signal, reverse).
Every model comes standard with impact sensors that perform a variety of
functions in case of a collision such as: turning off
electrical systems that could be dangerous, turning on hazard lights, and unlocking doors.
Electrical functions work as they should and occupants can enjoy the crushing performance of this Bentley
in peerless comfort and silence.
Brake pad wear sensors, Electric engine and trunk lid release, Multi
function display, On board computer, Outside temperature gauge, Variable power assisted steering, 2 speed front wipers + intermittent wipe, Aspherical driver's exterior mirror, Automatically extending rear spoiler, Body colour bumpers, Body colour door handles, Body colour electric / heated door mirrors, Coming home
function, Electric heated rear glass window, Electric windows one touch open / close,
Electrical soft - top actuation with comfort window lowering and closing of side windows, Front air dam with integrated air inlets, Front fog lights, Green tinted glass, Heated washer nozzles,Under - carriage cover, Water repellent side windows, Windscreen with grey top tint, Active carbon filter, Coat hook integrated into back seat, Continuously variable dimming interior light, Electrically adjustable backrest, Footwell illumination, Front centre console storage box, Front headrests, Front passenger seat isofix location point, Height / reach adjust steering wheel, Integrated double cupholders, Interior orientation lighting, Interior roof lining, Leather covered handbrake / gearlever / door pulls, Lockable glovebox, Luggage compartment lid front and rear
in aluminium, Rear centre console + storage compartment, Sports pedals, Storage compartments
in doors, Sunvisors with illuminated vanity mirrors, 3 point automatic seatbelts,Anti - lock Brake System + ABD,Anti - slip regulation, Driver and passenger airbags, Front seatbelt pretensioners + load limiters, Head airbags, Motor Slip Regulation - Engine Drag Torque Control, Passenger airbag deactivate switch, Side (thorax) airbags, Alarm, Locking wheel bolts, Remote control central locking, Transponder engine immobiliser, Porsche stability management (PSM), Tyre repair kit; including sealant foam
Options: Am / Fm Stereo W / Cd / Mp3 Player - Inc: Auto - Store Fm Diversity Antenna Auxiliary Input Located Inside Center Console Dvd Changer Prep Premium High - Fidelity 16 - Speaker Sound System - Inc: Digital Sound Processing (Dsp)(2) Subwoofers Under Front Seats 600 - Watt Digital 9 - Channel Amplifier Hd Radio W / Multicast Fm Station Reception Entertainment Server 12 Gb Hard Drive W / Usb Port For Media Transfer Body - Color Roof Trim Strips Power 2 - Way Tilt / Slide Glass Moonroof W / Key - Off & One - Touch Operation Sunshade Wind Deflector Body - Color Bumpers W / Hydraulic Energy Absorbers & (Front Only) Compressible Elements Power Adjustable Power - Folding Heated Auto - Dimming Body - Color Side - View Mirrors - Inc: 2 - Position Memory Rh Automatic Tilt - Down
In Reverse Illuminated Exterior Door Handles & Ground Illumination Intermittent Rain - Sensing Windshield Wipers W / Adjustable & Vehicle - Speed - Sensitive Wiping Interval Single - Wipe Control Windshield - Washer System W / Heated Washer Jets 19 X 8.5 V - Spoke Light Alloy Wheels (Style 426)- Inc: P245 / 45R19 Run - Flat All - Season Tires Led Fog Lights Automatic Trunk Lid Open / Close Xenon Rain - Sensing Adaptive Headlights - Inc: Dynamic Auto - Leveling Corona Headlight - Rings & Cornering Lights Retractable High - Intensity Headlight Washers Body - Color Exterior Door Handles Adaptive Brake Lights Pathway Lighting Feature Programmable Via Vehicle & Key Memory Power Soft - Close Automatic Doors Dual Cupholders Front & Rear Front Visors W / Illuminated Vanity Mirrors Dynamic Cruise Control Expanded Check Control Vehicle Monitor System Power Windows - Inc: Key - Off Operation One - Touch Open / Close Anti-Trapping Feature Coded Driveaway Protection Ambiance Lighting
In Front Rear & Door Panels Dual Illuminated Rear Vanity Mirrors Integrated Into Rear Cabin Roof Lining Vehicle & Key Memory Fully Finished Trunk Comfort Access Keyless Entry W / Multi-
Function Remote Rear Center Armrest W / Storage Compartment Rear Window Defogger Auto - Dimming Rear - View Mirror 4 - Zone Automatic Climate Control - Inc: Draft - Free Vents Solar Sensor Automatic Recirculation Heat - At - Rest Feature Automatic Ventilation Electronic Analog Speedometer & Tachometer Anti-Theft Alarm System - Inc: Interior Motion Detector Owner's Manual Condition - Based Service Display W / Additional
Functions Accessible Through Idrive System Central Power Locking System - Inc: Anti-Theft Feature Selective Unlocking Programmable Via Vehicle & Key Memory Nappa Leather Upholstery Black Panel Display W / Lcd Main & Trip Odometer Displays & Warning Indicators
In Dial Faces Front & Rear Floor Mats Hard Drive - Based Navigation System - Inc: Voice - Command & Real Time Traffic Info Fineline High Gloss Wood Interior Trim Power Tilt / Telescoping Steering Column Remote Trunk Release Heated Front Seats W / Fast Heating & Balance Control Front Console Compartment - Inc: Coinholder Illumination Multi-Contour 20 - Way Power Front Bucket Seats - Inc: 4 - Way Pwr Lumbar Support Articulated Upper Backrest Adjustable Backrest Width Adjustable Thigh Support Driver & Front Passenger Seat Memory Active Head Restraints W / Adjustable Side Support Integrated Universal Garage Door Opener Multi-
Function Sports Leather - Wrapped Steering Wheel - Inc: Audio Controls Phone Controls 2 - Position Memory Smokers Pkg Idrive System - Inc: On - Board Computer Controller (8) Programmable Memory Buttons 8 - Speed Automatic Transmission - Inc: Automatic & Manual Shift Modes Both W / Fully Synchronized Electronic Gear Changes Self - Leveling Air Spring Rear Suspension Rear Wheel Drive 4.4 - Liter Twinpower Turbo 32 - Valve 445 - Hp V - 8 Engine - Inc: Double - Vanos & Valvetronic Variable Valve Control High - Precision Direct Injection Dynamic Damping Control Driving Dynamics Control Front Multi-Link Double - Wishbone Aluminum Suspension Rear Multi-Link Integral - V Aluminum Suspension Brake Energy Regeneration To Convert Kinetic Energy Into Usable
Electrical Pwr 4 - Wheel Ventilated Disc Brakes W / Electronic Brake Proportioning Twin - Tube Gas - Pressure Shock Absorbers Vehicle - Speed - Sensitive Variable - Assist Variable - Ratio Rack - & - Pinion Power Steering Auto Start - Stop
Function Aluminum Front & Rear Subframes Electromechanical Parking Brake ** Preliminary Standard Equipment ** Front - Seat Side - Impact Airbags 3 - Point Safety Belt System - Inc: Alr
In All Passenger Positions Rear - View Camera Child Safety Rear Door Locks Anti-Lock Braking System (Abs) Driver & Front Passenger Dual - Threshold Dual - Stage Front Airbags W / Passenger Occupant Sensor Front & Rear Head Protection System (Hps) Corona Ring Integrated Daytime Running Lights Front & Rear Park Distance Control W / Graphic Display Emergency Interior Trunk Release Handle Front Safety Belt Automatic Pretensioners Acoustic Belt Warning Active Protection Bmw Assist W / Enhanced Bluetooth & Usb - Inc: (4) Years Of Automatic Collision Notification Emergency Request Enhanced Roadside Assistance Remote Door Unlock Stolen Vehicle Recovery Customer Relations Teleservice Mobile Office Features Myinfo Lower Anchors & Tethers For Children (Latch) On Rear Outboard Seats Dynamic Stability Control (Dsc)- Inc: Brake Fade Compensation Start - Off Assistant Brake Drying Brake Stand - By Dynamic Traction Control (Dtc) Dynamic Brake Control Crash Sensor That Activates Battery Safety Terminal Disconnect Of Alternator Fuel Pump & Starter From Battery Automatically Unlocks Doors Turns On Hazard & Interior Lights Tire Pressure Monitor Active Knee Protection
Yet, like all the S - class Coupe models, the S63 is better suited to a sporting waft:
in Comfort mode, the ride is superlative and the big chairs (distinct from the S - class saloon's) are hyper comfortable, with extraordinary support,
electrical adjustment and spine - friendly massage
functions.
European inquiries call +49 (0) 2041/777 -230 Standard Equipment: Painting: Obsidian Black Metallic Upholstery: BRABUS fine leather interior Cuoio / light brown (2 tone design) Trimming: Carbon / Piano wood (H10) Rear seats with memory
function First class rear seats Auxiliary heater with remote control Integrated garage opener
in inside mirror Telephone module Bluetooth Comfort telephone Ventilated seats front Ventilated seats rear
Electrical panoramic sliding roof Seat comfort package for driver and co-driver Head - up Display Tire Pressure control 360 degree camera COMAND Online Digital radio (DAB) Air - conditioning THERMOTRONIC rear Night view Assistant PLUS Interior trimming Poplar black shiny Burmester high - end 3D - surround - system DVD changer Remote control for COMAND multimedia system Tinted windows
in the rear TV - Tuner SPLITVIEW Chauffeur package Sun protection package KYELESS - GO - package Drive assistance package plus Parking - package Individual entertainment package fond Theft protection package Memory Package BRABUS Special Equipment: BRABUS engine 850 6.0 biturbo - displacement: 5,912 cc, Power: 625 kW (850 hp) at 5400 rev / min.
The new sports car generation makes its debut
in the classic Porsche pairing of Boxster and Boxster S. Both models are powered by flat - six engines with direct petrol injection, the efficiency of which is further enhanced by
electrical system recuperation, thermal management and start / stop
function.
In addition to its motor - generator duties, the crucial MG1 adds two
functions: One as a starter motor for the gas engine; and two, by regulating the amount of
electrical power it generates (which varies its RPM), MG1 controls the output speed of the transaxle through the planetary gear set — without clutches or viscous couplings.
The specially designed hybrid auto start - stop
function ensures that comfort is not affected even when the vehicle is stopped
in traffic for longer periods — because the automatic climate control and the on - board
electrical system are powered by the lithium - ion high - voltage battery.
An M Sport kit will be available for the X6, which includes 20 - inch M light alloy wheels
in double spoke design and bi-colour finish with mixed tyres, adaptive LED headlamps, BMW Individual high - gloss Shadow Line, black surrounds for the fog lights and M door sill cover strips, sports seats with
electrical adjustment and memory
function, M - specific Alcantara / Nappa leather combination
in black with M - style welt and contrast stitching, M leather steering wheel with shift paddles, M driver footrest, stainless steel pedals, interior strips
in Aluminium Flywheel black and the BMW Individual roof liner
in anthracite.
The system integrates auto start - stop, brake energy recuperation, a larger capacity battery and a starter motor that
functions as both an alternator and a motor that provides a mild
electrical boost
in certain driving conditions.
Application of numerous
electrical power reducing items (such as the use of efficient LED lighting and a special humidity control system that has an automatic air conditioning «off»
function) allows the BMS to operate the alternator even more frequently
in the more efficient low charge mode
Convenient use of the all - electric driving mode and the Auto Start Stop
function is likewise guaranteed
in this way, with all
electrical functions such as the audio system, climate control or navigation remaining fully available even with the combustion engine switched off.
When it comes to convenience, the new A8 impresses with its
electrical fold -
in exterior mirrors, the versatile and electrically adjustable front seats, the two - zone automatic air conditioning system, the
electrical adjustment of the steering column with easy exit
function, the ambient lighting, the electro - mechanical parking brake and the start - stop button.
The wide range of standard features includes
electrical seat adjustment complete with a memory
function and seat heating at the front, two - zone automatic air conditioning, extended Merino leather, a HiFi audio system with 12 loudspeakers and 230 Watt amplifier output, M entry trim, an M footrest, interior trim
in brushed Aluminium Shadow on both models as well as a BMW Individual instrument panel finished
in leather and automatic operation of the tailgate on the BMW X6 M.
Satellite Radio - Mahogany Metallic Body Fully galvanized with integrated frame Four door side impact protection beams Electric tilt / slide moonroof Water - repellent front - side windows Chassis Steel - Spring Suspension with Porsche Active Suspension Management (PASM) Front and rear stabilizer bars Vehicle stability system Porsche Stability Management (PSM) with ABS, ASR, ABD, MSR and Trailer Stability Management Double - wishbone front axle, multi-link rear axle 19 Cayenne Design wheels (8.5 x 19) with 265/50 tires Climate Control Systems Air conditioning system with integrated charcoal canister and pollen filter Tinted privacy glass and grey windshield strip Colors Solid Exterior Colors: White, Black Standard Interior Colors: Black, Agate Grey, Luxor Beige, Black / Luxor Beige E-Mobility Porsche universal charger (AC) with carrying bag for power cable Charging connection at the rear left to charge the high - voltage battery On - board charger with 3.6 kW Porsche Car Connect: e-mobility services Vehicle cable to connect the control unit with the vehicle, length: 2.5 m
Electrical Systems Universal audio interface (Aux - In / USB) Bluetooth hands - free mobile phone connection Power windows Two - speed wiper system with rain sensor, wiper delay control, heated washer nozzles Electrically operated and heated side mirrors Remote central locking with Anti-theft system including passenger compartment monitoring Cruise control Five 12 - volt outlets Power tailgate with fully automatic opening and closing including programmable, customized opening height Porsche Communication Management (PCM) with hard drive navigation module HD Radio unless replaced by option Infotainment Package w / o HD Radio Engine features Aluminum engine block and cylinder heads Wet - sump lubrication Direct Fuel Injection (DFI) Continuous intake and outlet camshaft control Cylinder - specific knock control Returnless fuel system Hydraulic valve adjustment MED 17 engine management system On - board diagnostics for monitoring emission control system Stereo Lambda control circuits Electronic throttle Vehicle electrical system recuperation Brake energy recovery Variable deceleration fuel cutoff Supercharger Auto Start Stop function Instruments Instrument cluster featuring 4 round black dials and silver tachometer with hybrid logo and ready indicator Instrument cluster with high - resolution 4.8 inch TFT color screen, gear indicator for Tiptronic S, service interval indicator, outside temp and various warning indicators plus en
Electrical Systems Universal audio interface (Aux -
In / USB) Bluetooth hands - free mobile phone connection Power windows Two - speed wiper system with rain sensor, wiper delay control, heated washer nozzles Electrically operated and heated side mirrors Remote central locking with Anti-theft system including passenger compartment monitoring Cruise control Five 12 - volt outlets Power tailgate with fully automatic opening and closing including programmable, customized opening height Porsche Communication Management (PCM) with hard drive navigation module HD Radio unless replaced by option Infotainment Package w / o HD Radio Engine features Aluminum engine block and cylinder heads Wet - sump lubrication Direct Fuel Injection (DFI) Continuous intake and outlet camshaft control Cylinder - specific knock control Returnless fuel system Hydraulic valve adjustment MED 17 engine management system On - board diagnostics for monitoring emission control system Stereo Lambda control circuits Electronic throttle Vehicle
electrical system recuperation Brake energy recovery Variable deceleration fuel cutoff Supercharger Auto Start Stop function Instruments Instrument cluster featuring 4 round black dials and silver tachometer with hybrid logo and ready indicator Instrument cluster with high - resolution 4.8 inch TFT color screen, gear indicator for Tiptronic S, service interval indicator, outside temp and various warning indicators plus en
electrical system recuperation Brake energy recovery Variable deceleration fuel cutoff Supercharger Auto Start Stop
function Instruments Instrument cluster featuring 4 round black dials and silver tachometer with hybrid logo and ready indicator Instrument cluster with high - resolution 4.8 inch TFT color screen, gear indicator for Tiptronic S, service interval indicator, outside temp and various warning indicators plus energy mgmt.