The virus was among the first samples analyzed with a new cryo -
electron microscopy system at Purdue, which was designed to operate at vastly higher resolution than previous instruments.
Not exact matches
The new 3 - D structure, which was obtained using X-ray crystallography and
electron microscopy, revealed that the outer surface of the Zika NS1 protein has substantially different electrical - charge properties than those of other flaviviruses — indicating it may interact differently with the members of an infected person's immune
system.
The researchers used a number of methods, including fluorescence and
electron microscopy, in collaboration with Dr. Eugenia Klein of the Institute's
Microscopy Unit; a unique
system in Prof. Alon's lab for simulating blood vessels in a test tube; and in vivo imaging with Prof. Sussan Nourshargh of Queen Mary University of London.
Thanks to cryo -
electron microscopy, «we have been able to visualise, for the first time, the high - resolution structure of the human R2TP
system,» states Llorca.
Advances in
electron microscopy and native mass spectrometry enabled the researchers to determine that a critical component of the signaling
system, anchored protein kinase A, remains intact during activation.
A similar combination of computational modeling based on quantum mechanics, molecular dynamics, and direct observation using
electron microscopy «can probably be applied to many
systems,» Buehler says.
Korenberg's team is developing a 3D coordinate
system to align various types of neuroimaging data in the macaque brain, from whole - brain MRI connectivity to single - cell confocal data and, for some areas, subcellular resolution with
electron microscopy.
Utilizes advanced
electron microscopy techniques to study nanoscale structure and defects that determine the utility of functional materials, such as superconductors, multiferroics, and other energy related
systems including thermoelectrics, photovoltaics, and batteries.
The goal of the FlyEM Project is to produce and analyze connectomes of behaviorally - relevant neural circuits in the entire Drosophila nervous
system using
electron microscopy.
At Janelia, the FlyEM Project is developing technology that will enable us to create a map of every neuron and synapse in the Drosophila nervous
system, using novel approaches to
electron microscopy (EM) as the foundation.
Following a PhD in transmission
electron microscopy at Cambridge, she spent three years at the National High Magnetic Field Laboratory at Los Alamos looking at the behaviour of the low temperature phases of strongly correlated
electron systems.
It is one of the market leaders in compound and stereo
microscopy, digital
microscopy, confocal laser scanning
microscopy with related imaging
systems,
electron microscopy sample preparation, and surgical microscopes.
The approaches combine theoretical studies — including statistical physics of non-equilibrium
systems — and a variety of experimental techniques such as optical and
electron microscopy, as well as microfluidics and micropatterning, optogenetics, or mechanical micromanipulation using optical or magnetic tweezers.
Currently he is Director of High Performance Computing
Systems and Applications at The Rockefeller University where his work supports applications in areas including cryo -
electron microscopy, super-resolution imaging and genomics.