Electrophysiological recordings refer to the process of measuring and recording electrical activity in the body or brain. It helps scientists study how cells and nerve signals work and can provide insights into various bodily functions and disorders.
Full definition
These findings were confirmed by two - photon imaging of neurons in the brains of living mice by the lab of collaborator Yi Zuo, PhD, a neuroscientist at UC Santa Cruz, as well
as electrophysiological recordings from neurons in brain slices by the lab of collaborator Vikaas Sohal, MD, PhD, an associate professor of psychiatry at UCSF.
Advances in optical imaging and optogenetics combined
with electrophysiological recordings enable Albeanu and colleagues to monitor and / or alter patterns of activity at unprecedented synaptic and millisecond resolution, in real time, as animals are engaged in various behaviors.
But, rather than studying the entire nervous system of a single model organism, Professor Graybiel has studied one brain region — a portion of the basal ganglia known as the striatum — in mice, rats, cats, monkeys, and humans using a whole range of technologies from microscopy
through electrophysiological recordings to genetics.
Electrophysiological recordings of these cells after culture for about 15 weeks revealed proper responses to currents and to inhibition of receptors needed for normal cerebellar signaling, indicating that function had developed along with structure.
Despite the mutation leading to a loss of function,
electrophysiological recordings from juvenile DS mouse heart cells paradoxically showed increased sodium current and a high incidence of abnormal re-excitation.
We used mutations with natural and unnatural amino acids,
electrophysiological recordings, and x-ray crystallography to identify a charge transfer center in voltage sensors that facilitates this movement.
The pair also developed a novel approach of
electrophysiological recordings and optogenetics to examine how exactly the double - projecting neurons connected to the mPFC and amygdala.
By combining in vivo labeling, confocal microscopy and
electrophysiological recordings, we identified an Aβ - induced aberrant neuronal network as the primary mechanism.
To this aim we have screened
our electrophysiological recordings of the magnocellular neurons, previously obtained from acute slices, with an analysis of autocorrelation of action potentials to detect a rhythmic drive as we recently did for organotypic cultures.