Sentences with phrase «elegans aging»

Our work will not only address fundamental questions about the mechanisms of aging, but also provide a platform to greatly accelerate C. elegans aging research.

«We can explain a lot of the disagreement in the C. elegans aging field by realizing that FuDR can dramatically change the answer,» Hart said.

Not exact matches

«In this study, we used the small roundworm C. elegans as a model to show that autophagy in the intestine is critical for lifespan extension,» said Malene Hansen, Ph.D., associate professor in SBP's Development, Aging, and Regeneration Program and senior author of the study.

One of his colleagues studies aging in nematodes (Caenorhabditis elegans), and he's considering changing his model organism.

Most mutations in C. elegans affect both life span and reproduction, which had led scientists to believe that body cells and female reproductive cells aged according to the same clock.

In a new study, Murphy, a molecular biologist at Princeton University, showed that long - lived bodily, or somatic, cells in Caenorhabditis elegans, a one - millimeter nematode commonly used as a model for aging studies in labs, activate genetic pathways completely separate from those found in long - lived egg, or oocyte, cells.

As with humans, he says, the oocytes of C. elegans also show an increase in chromosome abnormalities with aging.

When Murphy compared the genes turned off and on in oocytes and body cells of the same worm, however, she saw that two completely different sets of genes controlled oocyte and body - cell aging in C. elegans.

When Gordon Lithgow at the Buck Institute for Research on Aging in Novato, California, and colleagues grew the soil - dwelling nematode Caenorhabditis elegans in agar plates soaked in thioflavin T — a dye used to visualise clusters of amyloid beta protein — they found that the worms lived 30 to 70 per cent longer than average.

Longevity researchers have long turned to C. elegans to learn more about the human aging process.

Murphy found that the normal pattern of gene activation seen in aging wild - type C. elegans was reversed in the body cells and oocytes of IGF - 1 mutants.

As assistant director of the Institute of Healthy Aging at University College London, Gems regularly runs experiments on Caenorhabditis elegans, a roundworm that is often used to study the biology of aAging at University College London, Gems regularly runs experiments on Caenorhabditis elegans, a roundworm that is often used to study the biology of agingaging.

In matters of the fundamental molecular biology of aging, we mammals are not so different from tiny C. elegans worms.

«Like many labs, we use C. elegans — a tiny roundworm — as a model organism to reveal important lessons about aging and autophagy,» explains Hansen.

Tatar's research, along with simultaneous independent work by Linda Partridge of University College London, U.K., and her colleagues, demonstrated that an insulin - like signaling pathway controls diapause and aging in flies — similar to what had already been found in the roundworm Caenorhabiditis elegans (see «Growing Old Together»).

Like members of other species, microscopic C. elegans roundworms tend to act like other individuals their own age.

CK: We have studies in C. elegans showing that the daf - 2 gene functions exclusively in the adult to control aging.

The molecular details of aging are best known in the roundworm Caenorhabditis elegans.

A group of scientists have used a tiny roundworm called C. elegans to discover the mechanisms involved when multicellular organisms die, particularly as a result of old age.

In the nematode Caenorhabditis elegans, the presence of males accelerated aging and shortened the life span of individuals of the opposite sex (hermaphrodites), including long - lived or sterile hermaphrodites.

To that end, we have established a Caenorhabditis elegans model to study the effects of nutrients on α - DC and AGE - related pathologies.

Using this model we have identified a critical pathway and novel pharmacological compounds that can ameliorate AGE - related pathologies in C. elegans.

To study how splicing might affect aging, the researchers looked to Caenorhabditis elegans, a species of roundworm that's often used as a precursor to human tests in biological research, thanks to it having a genome very similar to ours.

In old C. elegans specimens, those treated with dietary restrictions (right) showed more youthful gene splicing patterns than naturally - aged animals (left)(Credit: Caroline Heintz)

«C. elegans is a great tool to study aging in because the worms only live for about three weeks, yet during that time they can show clear signs of age,» says Caroline Heintz, first author of the study.

In old C. elegans specimens, those treated with dietary restrictions (right) showed more youthful gene splicing patterns than naturally - aged animals (left)(Credit: Caroline Heintz)

Lithgow's recent work at the Buck Institute with the nematode C. elegans (a type of worm) has shown how iron accumulation can accelerate the aging process.

Metabolomics analysis uncovers that dietary restriction buffers metabolic changes associated with aging in Caenorhabditis elegans.

Not content to provide just the missing evidence for a 60 - year - old puzzle, Wilhelm and his colleagues went on to describe what a subset of these genes do in C. elegans and how they might be driving the ageing process.

Dr. Hansen's group focused on investigating the molecular mechanisms by which the nutrient sensor TOR modulates aging, using the nematode C. elegans as her primary model organism.

This year the organizers overtly recognized the history of our biomedical research niche in which C. elegans nematodes are used as a model organism (see our SAGE blog on how C. elegans models are used to study aging).

Daniel will be looking at the relationship between metal toxicity and aging in the nematode worm C. elegans — a new area of inquiry in the Lithgow lab.

In particular, research with the roundworm C. elegans, aided by its short lifespan and easily manipulated genetics, has identified a number of pathways that regulate aging, such as insulin / insulin - like signaling, dietary restriction, heat shock resistance, and reproductive and sensory signaling pathways.

We resorted to a widely used C. elegans model of Parkinson's disease, where we can measure the correlation between lifespan determined by aging and neuronal loss because the condition is not fatal.

The researchers first discovered ascarosides as a signaling molecule in C. elegans, a nematode used as a model organism to study cell, developmental and nervous system biology, as well as human aging and diabetes.

Even if the C. elegans model were not to capture a putative connection between Parkinson's disease and aging in humans, it serves as an eloquent signal that a clear distinction needs to be maintained between age - dependence (which is mere time - dependence) and aging - dependence (which is a dependence on the process that determines lifespan).

As one of the three initial cores established when the Buck Institute was founded, the Genomics Core has played a vital role in helping shape investigations in the basic molecular biology of aging, from assisting in the investigation of how specific drugs can extend lifespan in simple model organisms such as the nematode C. elegans, to facilitating studies in various animal models of age - related disease.

The broad conservation of neurohormonal signaling pathways between mammalian systems and C. elegans such as insulin - like signaling, serotonin, etc., validates studying the cell non-autonomous control of protein homeostasis by the nervous system of C. elegans to instruct our understanding of age - related human disease.

We will use SWADE to study the aging process in C. elegans.

We are studying the mechanisms that maintain multipotent cell fate during quiescence (reversible cell cycle arrest) using C. elegans as a model for aging stem cells.

Rogers studies the molecular mechanisms underlying aging in C. elegans, a tiny, soil - dwelling roundworm that is a favorite animal model in aging research because its short lifespan allows scientists to quickly assess the effect of anti-aging interventions and because it shares many of its genes with humans.

Genes that control the rate of aging have been uncovered by studies of many different species including: birds, rodents (especially mice), humans, yeast, the nematode worm Caenorhabditis elegans, and the fruit fly Drosophila melanosgaster.

How a low - carb diet helps against aging If humans resemble the worm Caenorhabditis elegans, they might live to a ripe old age by avoiding carbohydrates as much as possible.

Since several longevity mutants (such as long - lived C. elegans or Drosophilia mutants19 20) manifest defects in a signaling mechanism that normally slows the rate of autophagic waste recycling, Dröge and other researchers have postulated that the aging - associated decline of mitochondrial autophagy or «mitophagy» may be the first most limiting mechanism that determines maximum life span in most animal species, including man.21 22