Sentences with phrase «elegans as»

For 50 years of brilliant creativity in biomedical science — exemplified by his legendary work on the genetic code; his daring introduction of the roundworm Caenorhabditis elegans as a system for tracing the birth and death of every cell in a living animal; his rational voice in the debate on recombinant DNA; and his trenchant wit.

We are studying the mechanisms that maintain multipotent cell fate during quiescence (reversible cell cycle arrest) using C. elegans as a model for aging stem cells.

Using C. elegans as a model, Bargmann's laboratory characterizes genes and neural pathways that allow the nervous system to generate flexible behaviors.

In particular, I focus on chromosome segregation and cell division, using the nematode C. elegans as a model system.

Professor Horvitz had already made major contributions to understanding neural development using C. elegans as a simple model organism.

Caenorhabditis elegans as a chemical screening tool for the study of neuromuscular disorders: Manual and semi-automated methods.

Dr. Hansen's group focused on investigating the molecular mechanisms by which the nutrient sensor TOR modulates aging, using the nematode C. elegans as her primary model organism.

There, she has established the worm C. elegans as a novel model organism to examine the cellular transformations involved during a direct reprogramming event in vivo, as well as the genetic cascade involved.

Here we identify the protein encoded by the W01A8.1 gene in Caenorhabditis elegans as the closest homologue and likely orthologue of metazoan perilipin.

«I view C. elegans as a kind of live prototyping tool,» says Rabinowitch.

«In this study, we used the small roundworm C. elegans as a model to show that autophagy in the intestine is critical for lifespan extension,» said Malene Hansen, Ph.D., associate professor in SBP's Development, Aging, and Regeneration Program and senior author of the study.

Not exact matches

The entire genome of the tiny nematode (Caenorhabditis elegans) also has been sequenced as a ta - ngen = tial study to the human genome project.

Many of the most dramatic forms of selfishness, the murderous cheats, come from bacteria, so Werren welcomes the C. elegans scam as a rare case discovered in animals.

Magnified, the slime comes alive as hundreds of translucent worms, known as Caenorhabditis elegans, slither to and fro.

Data published by the International Human Genome Sequencing Consortium indicate that somewhere between 113 and 223 genes present in bacteria and in the human genome are absent in well - studied organisms — such as the yeast Saccharomyces cerevisiae, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans — that lie in between those two evolutionary extremes.

Strains of the lab workhorse roundworm C. elegans that lived longer added more time being frail and had the same portion of their lives being healthy as normal worms.

As California Institute of Technology neuroscientist Christof Koch noted in narrating the wiring diagram of the entire nervous system of Caenorhabditis elegans, we are clueless in understanding how this simple roundworm «thinks,» much less in explicating (and reproducing in a computer) a human mind billions of times more complex.

With worms as his subjects, he plumbs the cellular mechanisms driving the complex protein interactions regulating lifespan, some of which — remarkably — have been conserved through evolution all the way from his microscopic Caenorhabditis elegans to us.

While completing her postdoc, Murphy began to study C. elegans mutants that could live and reproduce twice as long as normal worms.

In a new study, Murphy, a molecular biologist at Princeton University, showed that long - lived bodily, or somatic, cells in Caenorhabditis elegans, a one - millimeter nematode commonly used as a model for aging studies in labs, activate genetic pathways completely separate from those found in long - lived egg, or oocyte, cells.

To answer this question, Murphy tracked which genes were turned on and off over time in the oocytes and somatic cells in C. elegans IGF - 1 and TGF - β mutants, as well as wild - type worms.

As with humans, he says, the oocytes of C. elegans also show an increase in chromosome abnormalities with aging.

As assistant director of the Institute of Healthy Aging at University College London, Gems regularly runs experiments on Caenorhabditis elegans, a roundworm that is often used to study the biology of aging.

He presented his idea one day to a roomful of about 30 colleagues at Yale's «Worm Meeting,» the weekly gathering for researchers studying C. elegans, the lowly nematode widely used as a model organism in developmental biology.

But it turns out that we have only about 25,000 genes — about the same number as a tiny flowering plant called Arabidopsis and barely more than the worm Caenorhabditis elegans.

Both studies relied on a popular lab organism known as C. elegans, a nearly microscopic nematode that is fast growing, translucent and has a sequenced genome showing that nearly half its genes are closely related to corresponding human genes.

Enormous projects such as ENCODE (for humans and mice) or modENCODE (for other lab model systems, such as the fly Drosophila or the worm C. elegans) have been devoted to collecting these data in order to analyse and interpret them in the framework of genomic data and to form hypotheses about functions and relations.

Curran and his colleagues tweaked the amount of Maf1 in C. elegans, a transparent worm often used as a model organism by biologists.

«Like many labs, we use C. elegans — a tiny roundworm — as a model organism to reveal important lessons about aging and autophagy,» explains Hansen.

This shows that TRH is essential to normal growth in human beings as well as in C. elegans,» biochemist Isabel Beets explains.

As a result, alcohol - exposed worms stop wriggling — the C. elegans version of the sluggish, uncoordinated behavior characteristic of inebriated humans.

To understand which proteins help meiosis run smoothly, the researchers from Kyoto University's Institute for Integrated Cell - Material Sciences (iCeMS) and Tohoku University in Japan, and Imperial College in London, used a tiny worm known as Caenorhabditis elegans to look into the role of PP4.

Scientists study the germline of the roundworm Caenorhabditis elegans to identify the mechanisms that control stem cell proliferation and homeostasis, as well as to advance our molecular understanding of homologous signaling pathways humans.

«C. elegans is a powerful tool for biological research because it shares many of the same anatomic and cell functions as humans, and their short lifespan (average 17 days) enables us to study genes and measure cell traits in just two to three weeks.»

Nematocida parisii, a newly discovered species of the protozoan parasites known as microsporidia, lives in the intestines of C. elegans, a small roundworm commonly used for research.

A side effect of losing PRMT - 5 in C. elegans is a heightened sense of smell: In the worms, dopamine signaling acts as a brake or check on the sensory system's response to odorants.

True to his drifter roots, Ruvkun has, since then, gamely followed the road of science as it has twisted and turned toward his current pursuit: studying the neuroendocrine control of metabolism, development, and longevity in C. elegans.

In the late 1970s and 1980s, «worm talks» (as C. elegans lectures were called) inevitably began with a description of development in the normal worm and segued to whatever mutants the lecturer found intriguing.

Mutations that make millimeter - long transparent worms known as Caenorhabditis elegans live longer also extend the proportion of their lives the worms spend being frail, Heidi Tissenbaum of the University of Massachusetts Medical School in Worcester and colleagues reported last year in the Proceedings of the National Academy of Sciences.

Finally Ruvkun's researchers came upon another grotesque mutant of C. elegans, known as let - 7, which literally bursts open in the final larval stage.

«And what this paper confirms in a theoretical model is that you don't need lots of neurons to perform these searches that include switching from a local to a global search — you can approximate it by using just three neurons, as in the roundworm C. elegans.»

Earlier, Dillin's group fingered the protein smk - 1 as a co-factor, which worked with daf - 16 to increase the life spans of nematodes (Caenorhabditis elegans).

«We're seeing something similar in the C. elegans pheromone sensitivity as well.»

For the first time, researchers at the University of Texas at Austin have pinpointed a specific pair of neurons that act as a magnetic sensor in the simple worm C. elegans.

Meanwhile, Esvelt and his colleagues are studying the CRISPR gene - drive system in the nematode Caenorhabditis elegans to learn more about what happens to a population as engineered DNA is passed down through generations, accumulating mutations as it goes.

Once believed to lack a sense of smell, dragonflies and damselflies, such as Ischnura elegans (pictured), possess olfactory bulbs in their antennae that may help them track prey.

Cold - water fish such as salmon are particularly rich in omega - 3's because they feed on plankton that manufacture the fatty acids, but the most sophisticated animal that can make its own omega - 3's is the worm Caenorhabditis elegans.

A group of scientists have used a tiny roundworm called C. elegans to discover the mechanisms involved when multicellular organisms die, particularly as a result of old age.

To study how splicing might affect aging, the researchers looked to Caenorhabditis elegans, a species of roundworm that's often used as a precursor to human tests in biological research, thanks to it having a genome very similar to ours.

As our role in the HapMap concluded, we took on a new grant: constructing the genetic map of C. briggsae, a small roundworm similar to the well - known model organism, C. elegans.