Apfeld J, Kenyon C. Cell nonautonomy of
elegans daf - 2 function in the regulation of diapause and life span.
One of the mutants carries a defect in Sch9, which resembles two genes in the C.
elegans daf - 2 pathway.
Not exact matches
Earlier, Dillin's group fingered the protein smk - 1 as a co-factor, which worked with
daf - 16 to increase the life spans of nematodes (Caenorhabditis
elegans).
CK: We have studies in C.
elegans showing that the
daf - 2 gene functions exclusively in the adult to control aging.
daf - 16 protects the nematode Caenorhabditis
elegans during food deprivation.
Chen et al. (62) combined mutation in
daf - 2 (similar allele to this study) with mutation in rsks - 1, C.
elegans S6 kinase to reveal extreme longevity.
Second, Ron's arguments are based on Cynthia Kenyon's experiments in the nematode worm C
elegans, in which she found that mutations to
Daf - 2, which is an insulin - like receptor in C
elegans, extended maximum lifespan.