Sentences with phrase «elegans live»

Mutations that make millimeter - long transparent worms known as Caenorhabditis elegans live longer also extend the proportion of their lives the worms spend being frail, Heidi Tissenbaum of the University of Massachusetts Medical School in Worcester and colleagues reported last year in the Proceedings of the National Academy of Sciences.

Among other things, Ruvkun's group scrutinized a hibernation phase in the C. elegans life cycle — the dauer larval stage — in which the nematode stops growing under unfavorable conditions.

Not exact matches

The research was performed on C. elegans, tiny roundworms that typically live an average of two weeks.

Strains of the lab workhorse roundworm C. elegans that lived longer added more time being frail and had the same portion of their lives being healthy as normal worms.

Using one of the great advantages of C. elegans, they were able to visualize the influx of calcium that occurred in a neuron in response to stimulus in a living worm.

These results showed that different genes control the life span of C. elegans and the length of reproductive time.

While completing her postdoc, Murphy began to study C. elegans mutants that could live and reproduce twice as long as normal worms.

Most mutations in C. elegans affect both life span and reproduction, which had led scientists to believe that body cells and female reproductive cells aged according to the same clock.

In a new study, Murphy, a molecular biologist at Princeton University, showed that long - lived bodily, or somatic, cells in Caenorhabditis elegans, a one - millimeter nematode commonly used as a model for aging studies in labs, activate genetic pathways completely separate from those found in long - lived egg, or oocyte, cells.

When Gordon Lithgow at the Buck Institute for Research on Aging in Novato, California, and colleagues grew the soil - dwelling nematode Caenorhabditis elegans in agar plates soaked in thioflavin T — a dye used to visualise clusters of amyloid beta protein — they found that the worms lived 30 to 70 per cent longer than average.

«I view C. elegans as a kind of live prototyping tool,» says Rabinowitch.

Xue said C. elegans is an ideal organism to use in the hunt for new therapeutics to treat nerve damage because of its relatively small, well - known genome and short life span — just a few days.

They counted the numbers of APs and ALs in different body tissues — intestine, muscle, pharynx (i.e., the animal's foregut), and neurons — at different time points during the adult life of C. elegans, and used chemical blockers to learn more about the dynamics of the process.

His students and postdocs call them the Lost Years: those 2 years in the»70s, long before he ever pondered the charms of a wriggling worm named Caenorhabditis elegans, when Harvard geneticist Gary Ruvkun lived the life of a long - haired hippie nomad.

Nematocida parisii, a newly discovered species of the protozoan parasites known as microsporidia, lives in the intestines of C. elegans, a small roundworm commonly used for research.

Earlier, Dillin's group fingered the protein smk - 1 as a co-factor, which worked with daf - 16 to increase the life spans of nematodes (Caenorhabditis elegans).

Thomas Johnson of the University of Colorado, for example, has bred a strain of the roundworm Caenorhabditis elegans which enjoys a 65 per cent increase in life span.

To fill in more blanks, Armand M. Leroi studied the metabolic profiles of the tiny worm Caenorhabditis elegans to see if they could find patterns related to life expectancy.

MBI scientists have discovered a feedback mechanism that regulates epithelial tube contractility in a living organism, the C. elegans nematode worm.

Species that live closer to shore, like the elegant cuttlefish (Sepia elegans), have also seen a steady rise in numbers, the researchers report today in Current Biology.

In the nematode Caenorhabditis elegans, the presence of males accelerated aging and shortened the life span of individuals of the opposite sex (hermaphrodites), including long - lived or sterile hermaphrodites.

Since the early 1990s, researchers have linked mutations in dozens of C. elegans genes to extension of the creature's life.

Apfeld J, Kenyon C. Cell nonautonomy of elegans daf - 2 function in the regulation of diapause and life span.

«C. elegans is a great tool to study aging in because the worms only live for about three weeks, yet during that time they can show clear signs of age,» says Caroline Heintz, first author of the study.

Next, the team used the process of dietary restriction, which has been shown to increase the lifespan of organisms like C. elegans, and observed that the worms» splicing patterns stayed youthful throughout the creatures» lives.

Publication T. Wilhelm et al., Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans, Genes & Development, 7 September 2017, DOI: 10.1101 / gad.301648.117

Visualization of fibrillar amyloid deposits in living, transgenic < i > Caenorhabditis elegans animals using the sensitive amyloid dye, X-34.

Researchers have discovered the molecular mechanisms by which the roundworm C. elegans senses oxygen concentrations in the highly variable soil environment where it lives.

When Filer and coworkers used RNA interference (RNAi) to knock down the amount of the largest subunit of Pol III, rpc - 1, in C. elegans, the worm lived longer.

It does seem to prevent them and extends life span in C. elegans.

The researchers then extended these studies to a living system, C. elegans, a well - studied model of Parkinson's disease.

In her scientific life, she is an associate professor in the Department of Genetics at the University of Wisconsin - Madison, where she studies cell division in the roundworm, C. elegans.

By deliberately introducing defined sequences of dsRNA into living organisms, biologists can observe the physiological consequences of «silencing» virtually any gene in C. elegans, as well as other plants and animals.

Reduced expression of the Indy (= I'm Not Dead Yet) gene, which encodes a cell surface transporter for tri - and dicarboxylic acids, prolongs life and health span in a manner akin to caloric restriction in D. melanogaster and C. elegans.

For 50 years of brilliant creativity in biomedical science — exemplified by his legendary work on the genetic code; his daring introduction of the roundworm Caenorhabditis elegans as a system for tracing the birth and death of every cell in a living animal; his rational voice in the debate on recombinant DNA; and his trenchant wit.

Certain life - extending agents help C. elegans respond to lifelong stress by remodeling the natural stress fighting cellular mechanisms, the Lithgow lab has found.

How a low - carb diet helps against aging If humans resemble the worm Caenorhabditis elegans, they might live to a ripe old age by avoiding carbohydrates as much as possible.

Since several longevity mutants (such as long - lived C. elegans or Drosophilia mutants19 20) manifest defects in a signaling mechanism that normally slows the rate of autophagic waste recycling, Dröge and other researchers have postulated that the aging - associated decline of mitochondrial autophagy or «mitophagy» may be the first most limiting mechanism that determines maximum life span in most animal species, including man.21 22

C. elegans mutants that live twice as long as wild - type worms in laboratory conditions typically die sooner than wild - type worms in a natural soil.