Sentences with phrase «elegans model»

Even if the C. elegans model were not to capture a putative connection between Parkinson's disease and aging in humans, it serves as an eloquent signal that a clear distinction needs to be maintained between age - dependence (which is mere time - dependence) and aging - dependence (which is a dependence on the process that determines lifespan).

We resorted to a widely used C. elegans model of Parkinson's disease, where we can measure the correlation between lifespan determined by aging and neuronal loss because the condition is not fatal.

Ultra-structural time - course study in the C. elegans model for Duchenne muscular dystrophy highlights a crucial role for sarcomere - anchoring structures and sarcolemma integrity in the earliest steps of the muscle degeneration process.

To that end, we have established a Caenorhabditis elegans model to study the effects of nutrients on α - DC and AGE - related pathologies.

This year the organizers overtly recognized the history of our biomedical research niche in which C. elegans nematodes are used as a model organism (see our SAGE blog on how C. elegans models are used to study aging).

Not exact matches

Her interest was piqued: Upon graduating in 1999 she joined the lab of Ding Xue at the University of Colorado, Boulder, to study how cell death is regulated in the model organism Caenorhabditis elegans.

Led by graduate student Patrick O'Hern, the team at Brown and the University of Cologne in Germany uncovered a complex cause - and - effect sequence in both C. elegans worm and mouse models of SMA.

«Radical signal to the progeny: Hlobin protein found in roundworm model Caenorhabditis elegans that is able to generate free radical signals.»

Sasha De Henau, a researcher at the Biology Department of Ghent University in Belgium recently discovered a globin protein in the roundworm model Caenorhabditis elegans that is able to generate such free radical signals.

«In this study, we used the small roundworm C. elegans as a model to show that autophagy in the intestine is critical for lifespan extension,» said Malene Hansen, Ph.D., associate professor in SBP's Development, Aging, and Regeneration Program and senior author of the study.

One of his colleagues studies aging in nematodes (Caenorhabditis elegans), and he's considering changing his model organism.

In a new study, Murphy, a molecular biologist at Princeton University, showed that long - lived bodily, or somatic, cells in Caenorhabditis elegans, a one - millimeter nematode commonly used as a model for aging studies in labs, activate genetic pathways completely separate from those found in long - lived egg, or oocyte, cells.

He presented his idea one day to a roomful of about 30 colleagues at Yale's «Worm Meeting,» the weekly gathering for researchers studying C. elegans, the lowly nematode widely used as a model organism in developmental biology.

Using the model organism, Caenorhabditis elegans, the researchers identified over 400 new mRNA editing sites — the majority regulated by ADR - 1 — and declared the protein the first global regulator of RNA editing.

Key aspects of ischemia - reperfusion can be modeled by a Caenorhabditis elegans behavior, the O2 - ON response, which is suppressed by hypoxic preconditioning or inactivation of the O2 - sensing HIF (hypoxia - inducible factor) hydroxylase EGL - 9.

Enormous projects such as ENCODE (for humans and mice) or modENCODE (for other lab model systems, such as the fly Drosophila or the worm C. elegans) have been devoted to collecting these data in order to analyse and interpret them in the framework of genomic data and to form hypotheses about functions and relations.

Curran and his colleagues tweaked the amount of Maf1 in C. elegans, a transparent worm often used as a model organism by biologists.

«Like many labs, we use C. elegans — a tiny roundworm — as a model organism to reveal important lessons about aging and autophagy,» explains Hansen.

In the classic genetic model Caenorhabditis elegans, the pro-apoptotic protein CED - 4 activates the CED - 3 caspase and is inhibited by the Bcl - 2 — like protein CED - 9.

To model the neurons, we'd have to measure from them, but this turns out to be more difficult for C. elegans than for mouse or even human neurons.

«And what this paper confirms in a theoretical model is that you don't need lots of neurons to perform these searches that include switching from a local to a global search — you can approximate it by using just three neurons, as in the roundworm C. elegans.»

His group studies the cellular and genetic control of gastrulation movements in zebrafish, one of the model organisms studied at the institute besides Drosophila, the C. elegans worm, frogs, mice, and newts.

If I hadn't met them at that conference, I wouldn't have found the mentoring support and advice I needed at a critical junction in my career, which ended up launching an entire field of researchers using C. elegans to explicitly model human disease.»

In the new study, Lee and his colleagues studied piRNAs produced by cells in the reproductive system of the nematode worm, C. elegans, a classic model organism studied by scientists to understand basic biological processes.

To demonstrate the device's capabilities, the researchers for the first time rotated C. elegans, a model organism about a millimeter in length that is frequently used in biological studies.

Using this model we have identified a critical pathway and novel pharmacological compounds that can ameliorate AGE - related pathologies in C. elegans.

Dubbed model - organism ENCODE (modENCODE), this new focus will apply innovative methods and technologies for the study of gene regulation to the smaller, and therefore more manageable, genomes of the fruit fly (Drosophila melanogaster) and the round worm (Caenorhabditis elegans).

As our role in the HapMap concluded, we took on a new grant: constructing the genetic map of C. briggsae, a small roundworm similar to the well - known model organism, C. elegans.

That year, I joined the lab of Raymond E. Miller, which played a role in the International HapMap Project and later the genetic map of C. briggsae, a model organism related to C. elegans.

Moreover, large - scale screens in the C. elegans DMD model allowed identifying genetic and pharmacologic suppressors of dystrophin - dependent muscle degeneration; some of them positively impact mitochondrial functions or structure under stress conditions, or are involved in signaling pathways linked to mitochondria, and others are associated to proteostasis pathways such as autophagy, proteasome and Unfolded Protein Response (UPR).

There, she has established the worm C. elegans as a novel model organism to examine the cellular transformations involved during a direct reprogramming event in vivo, as well as the genetic cascade involved.

Our strategy is based on the combination of genetics, imaging, electrophysiology and biochemistry in the nematode Caenorhabditis elegans (for more information on C. elegans see «an overview of the model organism C. elegans»).

AIP - 1 ameliorates β - amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model.

To identify novel genes and conserved cellular processes that regulate the biology of K2P channels in vivo we take advantage of the powerful genetic tools available in the model nematode Caenorhabditis elegans.

We also observe this process during development in C. elegans, and use measures of P granule growth rate, size distribution, and mechanical properties to test possible physical models that could underlie this behavior.

Dr. Hansen's group focused on investigating the molecular mechanisms by which the nutrient sensor TOR modulates aging, using the nematode C. elegans as her primary model organism.

Our lab uses a variety of model systems, such as the nematode C. elegans, as well as in vitro culture systems, to address fundamental questions in cell cycle control during development and tissue formation.

In a screen of nearly 200,000 compounds, Tardiff and collaborators identified one chemical entity that not only reversed alpha - synuclein toxicity in yeast cells, but also partially rescued neurons in the model nematode C. elegans and in rat neurons.

Most of the study's experiments were done in the roundworm C. elegans, which have an SMN gene and motor neurons — those that connect to muscle — that are very similar to humans, making them valuable models in which to study this disease.

Every year, VerMidi gathers the french research community using the model nematode C. elegans.

Role of extracellular polymeric substances in polymicrobial biofilm infections of Staphylococcus epidermidis and Candida albicans modelled in the nematode Caenorhabditis elegans.

They next turned to a couple of model organisms with more cells — nematodes, also known as C. elegans, and fruit flies, or Drosophila.

The researchers then extended these studies to a living system, C. elegans, a well - studied model of Parkinson's disease.

Professor Horvitz had already made major contributions to understanding neural development using C. elegans as a simple model organism.

Despite its power, RNAi is amazingly simple to perform in the roundworm C. elegans, an important model system for eukaryotic gene function.

C. elegans is a lab - friendly model species for research on how chemical signals affect development and behavior.

The animal model used for this study, C. elegans, is a nematode worm genetically engineered to produce human α - synuclein in its muscles.

Only one animal's full connectome has been constructed thus far: the roundworm C. elegans, which has a mere 302 neurons and serves as the model for research and data sharing in the field.

The researchers first discovered ascarosides as a signaling molecule in C. elegans, a nematode used as a model organism to study cell, developmental and nervous system biology, as well as human aging and diabetes.

In particular, I focus on chromosome segregation and cell division, using the nematode C. elegans as a model system.