Sentences with phrase «elegans with»

My laboratory investigates metabolite - directed communication systems in orchestrating cellular homeostasis and organismal health span, by harnessing the power of functional genomics in Caenorhabditis elegans with metabolomics, chemical engineering, and optical biophysics.»

An adult C. elegans with GFP coding sequence inserted into a histone - encoding gene.

The background image shows a picture of the nematode C. elegans with clumps of the Huntington's aggregates (bright green because they're tagged with green fluorescent protein) in the body wall muscle cells.

C. elegans with a green fluorescent protein (GFP) marker in the ASH neuron, the neuron that senses high pH.

Not exact matches

That's how many lab C. elegans nematodes grow a normal body (left) with a wide, inner feeding tube (partly visible toward worm top).

«I saw a picture of the C. elegans embryo with the microtubules all lit up,» she says.

The team at Salk started with a simple creature, the microscopic worm called Caenorhabditis elegans.

With worms as his subjects, he plumbs the cellular mechanisms driving the complex protein interactions regulating lifespan, some of which — remarkably — have been conserved through evolution all the way from his microscopic Caenorhabditis elegans to us.

But to my mind that is not how it has turned out — rather the reverse with a near equivalence of a modest 20,000 genes across the vast range of organismic complexity from the millimetre - long Caenorhabditis elegans to the 60 - trillion - celled Homo sapiens.

Kenyon works with a millimeter - long worm called Caenorhabditis elegans.

Working with a 900 - cell organism [C. elegans] is a far cry from working with humans.

As with humans, he says, the oocytes of C. elegans also show an increase in chromosome abnormalities with aging.

Tissue taken from mice with the C. elegans gene had significantly higher levels of omega - 3 acids compared with that of normal animals, the team found.

The C. elegans circuit for smell that the team looked at, for example, shares features with brain circuits for eyes in more complex animals.

Working in the laboratory of Heather A. Hundley, corresponding author on the paper and an assistant professor of biochemistry and molecular biology in the IU School of Medicine's Medical Sciences Program at Bloomington, Washburn and undergraduate Medical Sciences program student Emily Wheeler collaborated with the team from UCSD to show that the region of ADR - 1 protein that binds to target mRNAs in C. elegans is also required for regulating editing.

Except for houseflies, animal species tested with CR so far, including primates, rats, mice, spiders, Drosophila, C. elegans and rotifers, have shown lifespan extension.

After bombarding hundreds of Caenorhabditis elegans worms with DNA - altering chemicals and screening the results, he found that the deletion of just one gene rendered the worms almost completely resistant to alcohol.

Two projects will be done jointly with the Karolinska Institute in Stockholm: Molecular biologist David Baillie of Simon Fraser University in Burnaby, British Columbia, was awarded $ 6.73 million to study protein function in the soil nematode Caenorhabditis elegans, and microbiologist Sherif Abou Elela of the University of Sherbrooke, Quebec, received $ 3.75 million to test modified nucleic acid technologies for determining gene function.

Tatar's research, along with simultaneous independent work by Linda Partridge of University College London, U.K., and her colleagues, demonstrated that an insulin - like signaling pathway controls diapause and aging in flies — similar to what had already been found in the roundworm Caenorhabiditis elegans (see «Growing Old Together»).

Ralf Sommer of the Max Planck Institute for Developmental Biology in Tübingen, Germany, and colleagues compared Caenorhabditis elegans, which eats bacteria, with Pristionchus pacificus, which hunts other worms.

P. pacificus, however, has denser connections than C. elegans, with neural signals passing through many more cells before reaching the muscles (Cell, doi.org/kbh).

Behaviour similar to that of a PS has also been observed in fission yeast (S. pombe) and the roundworm (C. elegans), albeit with no molecular explanation.

Their most surprising discovery was that serotonin isn't the sole driver of this weight - loss pathway, but works in concert with another neurotransmitter, octopamine — the C. elegans version of adrenaline (also called epinephrine) in mammals.

In the late 1970s and 1980s, «worm talks» (as C. elegans lectures were called) inevitably began with a description of development in the normal worm and segued to whatever mutants the lecturer found intriguing.

There's a lot of attention right now on how neurons fire and interact with each other, but the truth is, we don't even understand how a brain develops — even in the most simple of organisms like C. elegans, a worm with only 300 brain cells.

Earlier, Dillin's group fingered the protein smk - 1 as a co-factor, which worked with daf - 16 to increase the life spans of nematodes (Caenorhabditis elegans).

In a recent paper in the journal Trends in Ecology and Evolution, Shapira, who studies the gut microbes of the nematode C. elegans, reviews evidence that demonstrates how microbiotas affect and contribute to host evolution, either by evolving along with the host, or by stepping in at critical moments to help the host adapt to a new environmental challenge.

With further experimental analysis, the scientists identified two distinct genetic variants that resulted in these sensitivity differences, suggesting that in crowded places, wild C. elegans populations with a specific genetic variation adopt different behaviors than those who doWith further experimental analysis, the scientists identified two distinct genetic variants that resulted in these sensitivity differences, suggesting that in crowded places, wild C. elegans populations with a specific genetic variation adopt different behaviors than those who dowith a specific genetic variation adopt different behaviors than those who don't.

His team trained Caenorhabditis elegans roundworms to associate the scent of a chemical, butanone, with a food reward.

In old C. elegans specimens, those treated with dietary restrictions (right) showed more youthful gene splicing patterns than naturally - aged animals (left)(Credit: Caroline Heintz)

C. elegans expressing a modified form of human amyloid - β survived three or four more days following infection in the gut with Candida albicans, compared to wild - type worms that did not express the peptide.

With only a single gene and a toolbox of forward and reverse genetic approaches at hand, C. elegans offers an opportunity to explore the exact role of perlipin - related factors in fat regulation throughout development of many different somatic and germline cells.

Studying polyglutamine aggregation in Caenorhabditis elegans using an analytical ultracentrifuge equipped with fluorescence detection.

In old C. elegans specimens, those treated with dietary restrictions (right) showed more youthful gene splicing patterns than naturally - aged animals (left)(Credit: Caroline Heintz)

Lithgow's recent work at the Buck Institute with the nematode C. elegans (a type of worm) has shown how iron accumulation can accelerate the aging process.

Metabolomics analysis uncovers that dietary restriction buffers metabolic changes associated with aging in Caenorhabditis elegans.

Dynactin - dependent cortical dynein and spherical spindle shape correlate temporally with meiotic spindle rotation in Caenorhabditis elegans.

She realised her postdoc with Iva Greenwald, at Columbia University NYC, on vulva organogenesis in C. elegans.

UNC - 98 and UNC - 96 interact with paramyosin to promote its incorporation into thick filaments of Caenorhabditis elegans.

She did her PhD on the transduction of the Notch signal in mammals in Alain Israël laboratory at the Pasteur Institute, Paris; she realised her postdoc with Iva Greenwald, at Columbia University NYC, on vulva organogenesis in C. elegans.

We used RNA - mediated interference to target 98 % of all genes predicted in the C. elegans genome in combination with differential interference contrast time - lapse microscopy.

In yeast and Caenorhabditis elegans, the majority of ORFs revealed by genomic sequencing have not been associated with mutant phenotypes, even in genomic regions that have been subjected to saturation mutagenesis (36 - 37).

They next turned to a couple of model organisms with more cells — nematodes, also known as C. elegans, and fruit flies, or Drosophila.

In its simplest form, RNAi requires little more than the ability to grow bacteria and observe C. elegans traits with a dissecting microscope.

In particular, research with the roundworm C. elegans, aided by its short lifespan and easily manipulated genetics, has identified a number of pathways that regulate aging, such as insulin / insulin - like signaling, dietary restriction, heat shock resistance, and reproductive and sensory signaling pathways.

After receiving her Ph.D. in 1987, Professor Bargmann transferred to the laboratory of H. Robert Horvitz, at MIT, where she became acquainted with the tiny worm C. elegans.

In particular, research with the roundworm C. elegans, aided by its short lifespan and easily manipulated genetics, has identified a number of pathways that regulate... >> MORE

However the only Boule homologs functionally characterized exhibit divergent roles in reproduction, with Drosophila boule necessary for male reproduction and the C. elegans boule homolog, daz - 1, required for egg production [39], [40].

These broad associations with complexity are evidently superimposed on notable lineage - specific variation as seen in Fig. 4 (for example, serine protease gene loss in C. elegans, and voltage-gated ion channel expansion in Paramecium).

The tiny roundworm C. elegans shares over 40 % of its genetic information with humans and its short lifespan makes it especially well - suited for defining genes that influence healthy lifespan.