Sentences with phrase «elements of the human genome»

What elements of the human genome are contributing to this process?

As long - time readers of MassGenomics probably know, I'm fascinated by studies that interrogate functional elements of the human genome.

DNA technology will continue to develop as we try to understand how the elements of the human genome work and interact with the environment.

Not exact matches

When her appointment came to a close, a colleague rolled his chair over to her one day and suggested her for a data scientist job with the Stanford - based Data Coordination Center of the ENCODE (Encyclopedia of DNA Elements) Consortium, an international collaboration of research groups funded by the National Human Genome Research Institute at the U.S. National Institutes of Health (NIH) in Bethesda, Maryland.

The human genome contains millions of sequences derived from so - called transposable elements, genetic units that «jump» around the entire genome.

EPFL scientists have carried out a genomic and evolutionary study of a large and enigmatic family of human proteins, to demonstrate that it is responsible for harnessing the millions of transposable elements in the human genome.

«We explored the opportunity of using sperm RNA elements as a predictor of human health, with applications at the fertility clinic that would go hand - in - hand with the new neonatal intensive care unit genome sequencing to better health outcomes,» said Dr. Krawetz, associate director of the C.S. Mott Center for Human Growth and Develophuman health, with applications at the fertility clinic that would go hand - in - hand with the new neonatal intensive care unit genome sequencing to better health outcomes,» said Dr. Krawetz, associate director of the C.S. Mott Center for Human Growth and DevelopHuman Growth and Development.

The study, the culmination of more than 10 years of research and published online in the journal Arthritis & Rheumatology in June, discovered virus - like elements within the human genome linked to the development of two autoimmune diseases: lupus and Sjogren's syndrome.

Among other initiatives, his group contributes to ENCODE (Encyclopedia of DNA Elements), supported by NIH to define functional genomic elements; the DOE Systems Biology Knowledgebase (KBase) for data sharing and analysis; and the internationally funded 1000 Genomes Project on human genetic vaElements), supported by NIH to define functional genomic elements; the DOE Systems Biology Knowledgebase (KBase) for data sharing and analysis; and the internationally funded 1000 Genomes Project on human genetic vaelements; the DOE Systems Biology Knowledgebase (KBase) for data sharing and analysis; and the internationally funded 1000 Genomes Project on human genetic variation.

Bejerano and his colleagues originally noticed ultraconserved elements when they compared the human genome to those of mice, rats and chickens, and found 481 stretches of DNA that were incredibly similar across the species.

The study, «VlincRNAs controlled by retroviral elements are a hallmark of pluripotency and cancer» found that novel non-coding parts of the human genome known as vlincRNAs (very long intergenic, non-coding RNAs) triggered by ancient viruses, participate in the biology of stem cells, and in the development of cancer.

Corn is an extreme example, but humans have plenty, too: Transposable elements make up nearly half of the human genome.

Retrotransposons, the most common type of transposable element in humans, make up about 45 percent of the human genome.

The latest research results are from the mouse ENCODE project, which is part of the ENCODE, or ENCyclopedia Of DNA Elements, program supported by the National Human Genome Research Institute (NHGRI), part of the National Institutes of Healtof the ENCODE, or ENCyclopedia Of DNA Elements, program supported by the National Human Genome Research Institute (NHGRI), part of the National Institutes of HealtOf DNA Elements, program supported by the National Human Genome Research Institute (NHGRI), part of the National Institutes of Healtof the National Institutes of Healtof Health.

«By means of basic research on model organisms, we are trying to understand human genome instability to identify elements, which, in the future, might be able to be explored as targets of new anti-tumour medicines,» explains the researcher responsible for the project and director of Cabimer, Andrés Aguilera.

One hint came in August, when a team led by biochemist Ramin Shiekhattar at the Wistar Institute in Philadelphia reported that a protein complex responsible for lashing the two copies of each chromosome together just before cell division binds to a repetitive element in the human genome.

By comparing the human genome to the genomes of 34 other mammals, Australian scientists have described an unexpectedly high proportion of functional elements conserved through evolution.

ENCODE was created to assemble a comprehensive catalog, or «parts list,» of all functional elements in the human genome.

By combining and comparing data from worm, fly and human, researchers can learn far more about the functional elements than if they analyzed the genome of just one organism.

However, approximately 168 Mb remained ambiguous (Table 2) which was more than double the 5.8 % of the total non-aligning human genome, the fraction of known ancestral bases not supported by ancestral elements (Table 1).

This was the most likely reason that ancestral element detection in mouse was so much lower than in human, as the genome - wide substitution rate in mouse is approximately twice that of human.

The polydeoxyadenylate tract of Alu repetitive elements is polymorphic in the human genome.

The National Human Genome Research Institute, part of the National Institutes of Health, has awarded $ 9.1 million over four years to a research team led by the University of Chicago to identify all regulatory elements, the DNA sequences that control when and where specific genes get turned on or off, in the fruit fly gGenome Research Institute, part of the National Institutes of Health, has awarded $ 9.1 million over four years to a research team led by the University of Chicago to identify all regulatory elements, the DNA sequences that control when and where specific genes get turned on or off, in the fruit fly genomegenome.

«Our project will serve as a pilot for the full - scale mapping of functional regulatory elements in the human genome,» said program director Kevin White, PhD, the James and Karen Frank Family Professor in the departments of Human Genetics and Ecology & Evolution, and Director of the Institute for Genomics & Systems Biology at the University of Chicago and Argonne National Laborahuman genome,» said program director Kevin White, PhD, the James and Karen Frank Family Professor in the departments of Human Genetics and Ecology & Evolution, and Director of the Institute for Genomics & Systems Biology at the University of Chicago and Argonne National LaboraHuman Genetics and Ecology & Evolution, and Director of the Institute for Genomics & Systems Biology at the University of Chicago and Argonne National Laboratory.

Scientists at Penn State College of Medicine, working alongside an international team of researchers, have produced the most complete encyclopedia of functional elements in the mouse genome to date and compared it to the human genome.

We focus on developing computational methods and tools for (a) analyzing large - scale gene expression data related to human cancer in search for gene markers and disease sub-categories, (b) identifying regulatory elements such as miRNA precursors and their targets in whole genomes of plants and mammals, (c) building theoretical models of gene regulatory networks.

Until recently, the human genome has been full of dark matter: enhancers, lncRNAs, repetitive elements, repressors, insulators, and more.

Green is the director of the National Human Genome Research Institute, which organized and paid for ENCODE (short for Encyclopedia of DNA Elements).

The Encyclopedia of DNA Elements (ENCODE) project set out to identify all the functional elements within the humanElements (ENCODE) project set out to identify all the functional elements within the humanelements within the human genome.

We report here a significant improvement in the resolution of array CGH, with the development of an array platform that utilizes single - stranded DNA array elements to accurately measure copy - number changes of individual exons in the human genome.

Gerstein is one of hundreds of researchers who participated in ENCODE, or the Encyclopedia of DNA Elements, a massive collaboration launched in 2003 to catalogue the human genome's every last piece.

We know, of course, that noncoding portions of the human genome contain functional elements contributing to phenotypic variation.

Recent studies indicate that long interspersed nuclear element - 1 (L1) are mobilized in the genome of human neural progenitor cells and enhanced in Rett syndrome and ataxia telangiectasia.

And now, the ENCODE Consortium has provided us exactly what they promised: an encyclopedia of the functional elements in the human genome.

A second, perhaps less - hyped initiative (called the Encyclopedia of DNA Elements, or ENCODE) set out to delineate all functional elements in the humanElements, or ENCODE) set out to delineate all functional elements in the humanelements in the human genome.

The DAXX co-repressor is directly recruited to active regulatory elements genome - wide to regulate autophagy programs in a model of human prostate cancer

About half of the sequence of the human and mouse genomes is derived from these mobile elements.

The goal of ENCODE is to build a comprehensive parts list of functional elements in the human genome, including elements that act at the protein and RNA levels, and regulatory elements that control cells and circumstances in which a gene is active.

He was a principal investigator of an ENCODE grant to devise strategies to map the binding of certain proteins to the human genome and to develop novel experimental approaches to examine specific classes of regulatory elements.

The ENCODE (Encyclopedia of DNA Elements) Consortium is an international collaboration of research groups funded by the National Human Genome Research Institute (NHGRI).

The findings, published in Nature, reveal millions of new regulatory elements in the human genome that in various ways govern how proteins are formed.

This latest expansion of the Encyclopedia of DNA Elements (ENCODE) project, or ENCODE 4, is funded by the National Human Genome Research Institute.

Only a minority of RNAs transcribed in a human cell goes on to template protein production, according to a 2007 assessment of the human genome by the Encyclopedia of DNA Elements (ENCODE) Project Consortium, which was funded by the National Human Genome Research Instihuman cell goes on to template protein production, according to a 2007 assessment of the human genome by the Encyclopedia of DNA Elements (ENCODE) Project Consortium, which was funded by the National Human Genome Research Instihuman genome by the Encyclopedia of DNA Elements (ENCODE) Project Consortium, which was funded by the National Human Genome Research Instgenome by the Encyclopedia of DNA Elements (ENCODE) Project Consortium, which was funded by the National Human Genome Research InstiHuman Genome Research InstGenome Research Institute.

Experiments to validate the existence of these and other predicted elements, and study their function within the cell, are expected to enhance understanding of how the human genome works.

In their new study published in Cell, the team investigated enhancers containing «ultraconserved elements,» which are at least 200 base pairs in length and are 100 percent identical in the genomes of humans, mice and rats.

As the model organism Encyclopedia of DNA Elements (modENCODE) project draws to completion this year, the National Human Genome Research Institute (NHGRI) is hosting a special symposium to celebrate the project's accomplishments.

The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, today announced approximately $ 31.5 million in grants this fiscal year, pending funds, as part of its latest expansion of the Encyclopedia of DNA Elements (ENCODE) project, or ENCODE 4.

Only an estimated 10 % of RNAs transcribed in a human cell go on to template proteins, according to a 2007 assessment of the human genome by the Encyclopedia of DNA Elements (ENCODE) Project Consortium, which was funded by the National Human Genome Research Instihuman cell go on to template proteins, according to a 2007 assessment of the human genome by the Encyclopedia of DNA Elements (ENCODE) Project Consortium, which was funded by the National Human Genome Research Instihuman genome by the Encyclopedia of DNA Elements (ENCODE) Project Consortium, which was funded by the National Human Genome Research Instgenome by the Encyclopedia of DNA Elements (ENCODE) Project Consortium, which was funded by the National Human Genome Research InstiHuman Genome Research InstGenome Research Institute.

Termed «ultraconserved elements» or UCEs, these portions of the genome have remained unchanged for 300 to 500 million years, appearing in the same state across multiple animal species — from humans to dinosaurs to platypuses.

Despite the significant insights gained from large - scale studies designed to interpret this instruction book, including HapMap, Encyclopedia of DNA Elements (ENCODE), and genome - wide association studies (GWAS), our knowledge of the human genome remains far from complete.