When
elevating calcium ion
concentration directly at the presynaptic terminal with the use of caged
calcium, cleavage of SNAP - 25 by botulinum toxin A (BoNT / A) produced a strong reduction in the
calcium sensitivity for release, whereas cleavage of syntaxin using BoNT / C1 and synaptobrevin using tetanus toxin (TeNT) produced an all - or - nothing block without changing the kinetics of remaining vesicles.
Further experiments revealed that injured cells initiate a wave of
elevated calcium ion
concentration that travels through the brain, and that the microglia only begin migrating when the wave reaches them.
Elevated atmospheric CO2 is associated with decreased plant nitrogen
concentration, and therefore decreased protein, in many crops, such as barley, sorghum, and soy.210, 211,212,213 The nutrient content of crops is also projected to decline if soil nitrogen levels are suboptimal, with reduced levels of nutrients such as
calcium, iron, zinc, vitamins, and sugars, although this effect is alleviated if sufficient nitrogen is supplied.214 Fourth, farmers are expected to need to use more herbicides and pesticides because of increased growth of pests215, 216,217,218 and weeds219, 220 as well as decreased effectiveness221 and duration222of some of these chemicals (Ch.