Sentences with phrase «elevated cytokine levels»

Not exact matches

«Strong link between delirium, inflammation in older patients: Study of post-surgical patients shows elevated levels of inflammatory cytokines are strongly associated with delirium.»

Affecting the skin in regions containing apocrine sweat glands, HS is believed to be caused by immune system abnormalities, and elevated levels of the inflammatory factors called cytokines — including TNF — have been detected in HS lesions.

We observed no significant effect of genotype for any of these genes (data not shown), indicating that 7 - to 8 - month - old Grn − / − mice have not yet developed the elevated levels of inflammatory cytokines found at older ages (Filiano et al., 2013).

In the context of inflammation, however, cortisol, prolactin, and sex hormones are often dysregulated; in this model, depression is thought to represent a hypercortisolemic state which may result from elevated levels of inflammatory cytokines.

Furthermore, it is usually associated with elevated levels of pro-inflammatory cytokines and acute phase proteins, such as interferons (IFNs), interleukin (Il)-1, Il - 6, tumor necrosis factor - α (TNF - α), and C - reactive protein (CRP).

Magnesium - deficiency elevates circulating levels of inflammatory cytokines and endothelin

There is a direct inverse correlation between CRP and reduced tissue T3 (112,270), so individuals with elevated CRP (greater than 3 mg / l) or other inflammatory cytokines will have a significant reduction in cellular T3 levels.

When levels of body - wide inflammatory cytokines are elevated, they can subsequently signal the production of inflammatory cytokines within the central nervous system via microglia activation.

Both inflammatory bowel disease and gastrointestinal Candida colonization are associated with elevated levels of the pro-inflammatory cytokine IL - 17.

-RCB- elevated sodium level within kidneys, either as a result of pathological bottleneck such as reduced number of nephrons, or simply due to heightened intake - or both - may activate pro-inflammatory cytokines and chemokines in proximal tubular cells, may cause oxidative stress by activating ROS - producing NADH oxidase enzymes, or blood vessel constriction by inhibiting kidney arginine transport and nitric oxide synthesis; elevated renal inflammation, oxidative stress and restricted blood flow all can impair the efficacy of sodium excretion, more so combined (if extensive, it can also result in post-natal reduction of nephron units)

Although greater early local production of proinflammatory cytokines at wound sites is beneficial because it is associated with enhanced healing, greater systemic production of proinflammatory cytokines can represent a maladaptive response.24 Both physical and psychological stressors can provoke transient increases in plasma levels of proinflammatory cytokines, particularly IL - 6,25 as can negative emotions like depression and anxiety.26 - 28 More frequent or persistent stress - related changes have broad implications for physical and mental health; sustained elevated levels of proinflammatory cytokines have been linked to a variety of age - related diseases, including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes mellitus, certain cancers, and frailty and functional decline.29 - 31

These changes are important because both stressors and depression can sensitize the inflammatory response in such a way that they produce heightened responsiveness to stressful events as well as antigen challenge.25, 27,28,60 Furthermore, more frequent or persistent stress - related changes in plasma levels of these key cytokines have broad implications for health; elevated levels of proinflammatory cytokines have been linked to a variety of age - related disease, including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes mellitus, certain cancers, and frailty and functional decline.29 Moreover, inflammatory activation can enhance development of depressive symptoms.30, 31 Thus, relationships characterized by hostility, repeated conflicts, and heightened IL - 6 levels could have negative consequences for both physical and mental health.