Sentences with phrase «elevated expression levels»
In one, he found elevated expression levels of the gene MSH2, whose product is a known DNA repair enzyme.
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Of husbands they said, «If elevated levels of sexual activity are maintained from earlier years and if neither acute nor chronic physical incapacity intervenes, aging males usually are able to continue some form of active sexual expression into the 70 - and even 80 - year age groups.»
Elevated miR - 182 expression already is associated with premature aging of the eye and, when MCG scientists mimic premature aging by applying hydrogen peroxide, miR - 182 levels increase.
Using data from a large public brain tumor database called REMBRANDT, the researchers confirmed that patients with lower levels of SND1 survived longer than those with elevated SND1 expression.
Recent studies have found elevated levels of this protein in post-mortem brain samples of patients with MS.. In this latest work, investigators compared the frequencies of «more active» and «less active» variants of the DNA sequences that control expression of the galanin gene between healthy controls and MS patients.
They also stressed that IL - 6's role in inflammation «extends well beyond the immune system and the kidney, with high levels of expression in atherosclerotic plaques and elevated serum levels being associated with increased coronary artery disease and morbidity from hypertension, left ventricular hypertrophy, and development of insulin resistance.»
They found that the immune cells of 71 HIV - infected subjects had elevated levels of PD - 1 expression compared to uninfected controls.
In line with our in vitro data, Pkn1 — / — mice showed AKT hyperactivation, elevated NeuroD2 levels, and reduced expression of PF - PC synaptic markers during stages of PF maturation in vivo.
In contrast to studies that correlated elevated levels of IGF - 1 with the risk of developing prostate cancer, Greenberg's research showed that eliminating IGF - 1R expression in an otherwise normal mouse prostate caused the cells to proliferate and become hyperplastic.
Figure 1B shows that after 0.5 h of hypoxia, HIF - 1α protein levels (normalized to levels of β - actin protein expression) were elevated approximately sevenfold relative to the control.
Long - term expression of murine activated factor VII is safe, but elevated levels cause premature mortality.
Similarly, iNOS expression levels were elevated in vehicle - treated PDGF - AS mice, but held to WT levels in animals receiving AFF 1 vaccine.
The high expression levels of two genes (DNMT3A and DNMT3B) related to DNA methylation in our study is also consistent with a mouse study showing the elevated methylation in parthenotes compared to IVF / ICSI embryos [39].
Elevated gene expression levels distinguish human from non-human primate brains.
Our findings are consistent with other studies also reporting elevated levels of oxidative stress markers in the eyes of POAG patients, along with altered expression of antioxidant defenses in the TM.
Venus positive cells experiencing low - level transcription at the Hex locus, but still expressing the ES cell markers SSEA - 1 and Oct4, show elevated levels of PrEn gene expression and reduced levels of early ICM markers such as Nanog.
By increasing expression of Ran, the researchers were able to elevate TDP - 43 levels in the nucleus of progranulin - deficient neurons and prevent their death.
We confirmed that the protein level of APC was elevated and the expression of miR - 150 was decreased in the human breast cancer xenograft cells transfected with the anti-miR-142-3p lentivirus (Figure 5E and Figure 7B).
In a 2016 study in the journal Pediatrics, transgender children who socially transitioned (meaning they have changed their gender expression, choosing to go by a different name and pronouns and possibly also altering their clothing and hairstyle) and felt supported in their identities had normal levels of depression and only slightly elevated levels of anxiety compared to kids whose gender identity corresponded to their birth sex.
Besides changing the expression of NMDA receptors, prebiotic treatment also elevates levels of different amino acids such as glutamate and glutamine in the feces of GOS - fed rats.
MuRF - 1 mRNA expression was elevated 2 h following exercise but had returned to basal levels, by 8 h in all treatments.
«Indeed, the exterior design of the new BMW M3 and BMW M4 has a visual impact that elevates the BMW M design language to a new level of expression, highlighted by a purposeful character, emotional appeal and dynamic verve.»
«Indeed, the exterior design has a visual impact that elevates the BMW M design language to a new level of expression, highlighted by a purposeful character, emotional appeal and dynamic verve.»
Voulkos created sculpture that elevated the medium of ceramics to «new levels of abstraction and personal expression,» in the words fo The New York Times arts writer Roberta Smith.
Reduced amygdala responses to fearful facial expressions have been reported in adolescents with CD or conduct problems, and elevated CU traits compared to typically - developing controls (Jones et al. 2009; Marsh et al. 2008), whereas increased amygdala responses to fearful faces have been demonstrated in children with conduct problems and low levels of CU traits compared with their high CU traits counterparts (Viding et al. 2012).