Sentences with phrase «elevated plasma levels»

The results suggest that elevated plasma levels of inflammatory biomarkers, including complement proteins, associate with polygenic risk scores in AD, further strengthening the link between genetic and biomarker disease predictors and indicating a potential role for these markers in disease prediction and patient stratification in AD.

Not exact matches

The Stanford team found, however, that mitochondrial DNA levels were significantly elevated in plasma samples from a small number of HD patients.

The team found that cord plasma has elevated levels of a protein called TIMP2.

Metabolic syndrome is defined as abdominal obesity and elevated blood pressure, plasma glucose, serum triglycerides, or low high - density - lipoprotein levels and can lead to type 2 diabetes.

Abetax - 40 levels were elevated approximately 2 - to 5-fold in plasma and decreased up to 64 % in CSF in immunized vervets.

The iLpldf mice presented with elevated plasma TG and cholesterol levels (Supplemental Figure 5, C and D, respectively), along with a dramatic increase in VLDL TGs and a reduction in HDL cholesterol levels (Supplemental Figure 5, E and F), as observed in patients with LPL deficiency (16).

Elevated plasma TG levels represent a risk factor for CVD in humans, and an adjusted analysis of patients in the Framingham Heart Study suggests that each decrease of 1 mg / dl in plasma ApoC - III levels is associated with a 4 % decrease in CVD risk (11), further supporting the potential therapeutic benefit of suppressing plasma ApoC - III levels in humans to reduce CVD.

However, a recent clinical study showed that lowering plasma ApoC - III levels with volanesorsen, a generation 2.0 + ApoC - III — specific antisense oligonucleotide (ASO), dramatically lowered elevated plasma TG levels in patients who have genetic defects in LPL (familial chylomicronemia syndrome [FCS]-RRB-(16).

As expected, animals fed a high - fat diet had elevated plasma cholesterol levels (Figure 5D).

Fructose - induced in vivo insulin resistance and elevated plasma triglyceride levels in rats.

This residual risk has shifted attention to elevated plasma triglyceride (TG) levels, which constitute an independent risk factor for coronary artery disease.

In one study, a single oral dose of 5 grams of gamma aminobutyric acid administered to 19 subjects significantly elevated plasma growth hormone levels.

Hepatic IR ensues, increasing endogenous glucose production, hence elevating plasma glucose levels and stimulating further insulin secretion.

More recently, a 2008 study found that plasma 5α - DHT levels were reduced when testosterone was given to elderly men with below normal levels of testosterone and elevated 5α - DHT levels at baseline.

Saliva testing is not a reliable option for even a snapshot evaluation of androgen levels or for monitoring the absorption of sex hormones from transdermal creams, which are likely to show elevated salivary hormone levels, while plasma and urinary levels remain low.1

Assuming a high quality whey protein isolate can elevate plasma glutathione levels, how does that tie - in to Parkinson's disease?

In this case, research shows that eating protein (and thus elevating plasma amino acid levels) before training can help you build muscle faster.

Lastly casein protein has the slowest absorption rate but in doing so it elevates plasma amino acid levels for the longest period of time.

Phenylketonunics, who have a genetic error of phenylalanine metabolism, have elevated serum plasma levels of phenylalanine up to 400 times normal.

Evidence of the refractory phenomenon was shown by Bohé et al. [117], who elevated plasma amino acid levels in humans and observed that MPS peaked at the 2 - hour mark, and rapidly declined thereafter despite continually elevated blood amino acid levels.

Low serum levels of certain B vitamins (folate and vitamins B12 and B6) have been associated with elevated plasma homocysteine levels in several studies and with an increased risk of dementia in a few investigations.38 - 42 In our study, the observed association between plasma homocysteine and risk of dementia was not significantly altered by adjustment for the plasma levels of these vitamins (Table 3).

Your plasma (blood) amino acid levels are still going to be elevated from the meal, which would make eating more protein before you train unnecessary.

In relation to CVD, elevated blood pressure has been shown to be positively associated with higher intakes of red and processed meat, even though the mechanism is unclear, except that possibly meat may substitute for other beneficial foods such as grains, fruits, or vegetables.32 Mean plasma total cholesterol, low - density lipoprotein cholesterol, very - low - density lipoprotein cholesterol, and triglyceride levels were found to be decreased in subjects who substituted red meat with fish.33, 34 Vegetarians have lower arachidonic, eicosapentaenoic, and docosahexaenoic acid levels and higher linoleate and antioxidant levels in platelet phospholipids; such a biochemical profile may be related to decreased atherogenesis and thrombogenesis.34 - 36

In Bernice's scenario, lymphoma and plasma cell tumors are the most common causes of elevated globulin levels.

Biochemistry - elevated plasma proteins, elevated plasma fibrinogen levels, elevated bilirubin, slight elevation of liver enzymes, slight elevation of BUN.

Ethylenediaminetetraacetic acid (EDTA) preserves cellular components for CBC and morphologic evaluation but falsely decreases calcium, phosphorus, and alkaline phosphatase levels and elevates potassium levels; therefore, EDTA plasma samples should not be used for chemical analysis.

Although greater early local production of proinflammatory cytokines at wound sites is beneficial because it is associated with enhanced healing, greater systemic production of proinflammatory cytokines can represent a maladaptive response.24 Both physical and psychological stressors can provoke transient increases in plasma levels of proinflammatory cytokines, particularly IL - 6,25 as can negative emotions like depression and anxiety.26 - 28 More frequent or persistent stress - related changes have broad implications for physical and mental health; sustained elevated levels of proinflammatory cytokines have been linked to a variety of age - related diseases, including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes mellitus, certain cancers, and frailty and functional decline.29 - 31

Persistence of subsyndromal residual symptoms after remission of major depression in patients without cardiovascular disease may condition maintenance of elevated platelet factor 4 and β - thromboglobulin plasma levels.

These changes are important because both stressors and depression can sensitize the inflammatory response in such a way that they produce heightened responsiveness to stressful events as well as antigen challenge.25, 27,28,60 Furthermore, more frequent or persistent stress - related changes in plasma levels of these key cytokines have broad implications for health; elevated levels of proinflammatory cytokines have been linked to a variety of age - related disease, including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes mellitus, certain cancers, and frailty and functional decline.29 Moreover, inflammatory activation can enhance development of depressive symptoms.30, 31 Thus, relationships characterized by hostility, repeated conflicts, and heightened IL - 6 levels could have negative consequences for both physical and mental health.