Sentences with phrase «elevating calcium ion»
When elevating calcium ion concentration directly at the presynaptic terminal with the use of caged calcium, cleavage of SNAP - 25 by botulinum toxin A (BoNT / A) produced a strong reduction in the calcium sensitivity for release, whereas cleavage of syntaxin using BoNT / C1 and synaptobrevin using tetanus toxin (TeNT) produced an all - or - nothing block without changing the kinetics of remaining vesicles.
http://science.sciencemag.org/
Further experiments revealed that injured cells initiate a wave of elevated calcium ion concentration that travels through the brain, and that the microglia only begin migrating when the wave reaches them.