Sentences with phrase «eliminate tumor cells»

The bacteria serves as a delivery system to introduce the cancer marker to the patient's immune system and instruct it to eliminate the tumor cells that express this marker.

The process works by introducing healthy immune cells, or T cells, that eliminate tumor cells and prevent the cancer from relapsing.

In addition, understanding the genetic differences between the subpopulations could lead to novel treatment strategies aimed at eliminating tumor cell communities.

But against stomach cancer, they completely eliminated tumor cell growth.

Not exact matches

Macrophages play numerous roles within tumors, leaving cancer researchers with a choice: eliminate the cells or recruit them.

According to Srikumar P. Chellappan, Ph.D., chair of the Department of Tumor Biology at Moffitt, «these cells can also contribute to the metastasis of tumors as well as the reappearance of tumors after they have been eliminated from the body.»

In the context of the collaboration between the Gates Center for Stem Cell Biology and the CU Cancer Center this was the second clinical trial we offered to our patients with the specific intent to eliminate the CSCs in their tumors.»

They found that NF - κB, a protein complex known to promote tumor growth, may also have the ability to boost the immune system to eliminate cancerous cells before they harm, as well as promote antitumor responses.

In a previous study, his team worked with other collaborators to identify the potential role of extra copies of the tumor suppressor gene (p53) that increase the elephant's ability to eliminate pre-cancerous cells with DNA damage.

In experiments involving mice injected with human GBM cells, the scientists also demonstrated that if either PTEN or DAXX were eliminated, then tumor growth occurred.

For most available T cell immunotherapies, T cells (which play a central role in defending the body against illness) are engineered to recognize and eliminate tumors, but their activity is not specifically controlled, leading to toxicity and unwanted side effects in patients as a result of inflammation or in some cases suboptimal response to treatment.

For example, in colorectal cancer lab models, where a mutation in the beta - catenin gene drives MYC to cancerous levels, eliminating PVT1 from these cells made the tumors nearly disappear.

The human immune system is poised to spring into action at the first sign of a foreign invader, but it often fails to eliminate tumors that arise from the body's own cells.

The study, which appears August 3 in the peer - reviewed journal Nature Communications, showed that pairing the chemotherapy with an experimental drug eliminates the deadly population of cells believed to be responsible for repopulating the tumor.

As a result, the immune system, he says, «can identify antigenic differences between the foreign (tumor) and normal, and then go out and eliminate all cells displaying the foreign (tumor) antigens.»

This could help eliminate the residual cancer cells that often form new tumors following surgery.

As an additional safety feature, the researchers introduced two mutations that weakened the virus's ability to combat the cell's defenses against infection, reasoning that the mutated virus still would be able to grow in tumor cells — which have a poor antiviral defense system — but would be eliminated quickly in healthy cells with a robust antiviral response.

The effects of consuming emulsifiers were eliminated in mice devoid of microbiota (germ - free mice), and transplanting microbiota from emulsifier - treated mice to germ - free mice was sufficient to transfer alterations in intestinal epithelial cells» homeostasis, suggesting a central role played by the microbiota in tumor development.

Up to now, it was assumed that by suppressing the telomerase activity, tumor cells might be eliminated due to telomere shortening.

Such resistance may help explain why drugs that eradicate tumor cells in laboratory dishes often fail to eliminate malignancies in the body

Hence, BH3 mimetics might represent an attractive approach of eliminating resistant subpopulations of cancer cells, thereby targeting both tumor cell invasion and cancer relapse.

Now, patients with pancreatic cancer desperate for new treatment options will potentially benefit from a powerful new technology that uses genetic engineering to turn their own immune cells into «specially trained assassins» capable of finding, attacking, and eliminating pancreatic cancer tumors.

Attempts to eliminate the tumor - initiating cell population generated by EMT are hampered by their increased resistance against most conventional cancer therapeutics.

Because Tregs act to keep the immune system in check, they can inadvertently blunt the ability of immune cells to restrain or eliminate tumors.

When transplanted into wild - type mice with intact immune systems, these tumors are eliminated, presumably by T - cells.

Chemotherapy — chemotherapy may be required before surgery (to shrink the tumor and / or control spreading), after surgery (to eliminate any cancerous cells still present), or both.

Going directly from one adult cell type to another would eliminate the risk that some stem cells might develop inappropriately to form tumors.

It is widely believed that cellular senescence is a tumor suppressor mechanism; however, it has not been understood why it is advantageous for organisms to retain mutant cells is a postmitotic state rather than simply eliminating them by apoptosis.

Here, we elaborate on how these findings pertain to cancer cells dispersed in the tumor - adjacent stroma of breast cancer tissues, and how BH3 - mimetics may provide a therapeutic strategy to eliminate cancer cell populations that have passed through an EMT.

By identifying phenotypes that are shared among tumors with different aneuploidies, we hope to discover pathways that can be manipulated to selectively eliminate aneuploid cells or to block aneuploidy's non-cell autonomous effects.

6 - shogaol is 10,000 times more effective than increased doses of Taxol at eliminating cancer stem cells, keeping healthy cells alive, and stemming the formation of tumors.

The best treatments zero in on the tumor and eliminate only malignant cells while training the white blood cells to fight any sign of tumor cells.

Special Areas of Interest: Osteosarcoma, plasma cell tumors, lymphoma, mast cell tumors, and investigating ways in which the immune system can be modified to better recognize and eliminate cancer cells.

The U.S. National Library of Medicine describes four goals of chemotherapy: to eliminate all of the cancer cells from the body, to eliminate the cancer cells that remain in the body following surgery, to reduce tumors before surgery and to reduce side effects or slow the spread of the cancer.