Not exact matches
The difficulties associated with obtaining nerve tissue at the
correct stage of development and differentiation from aborted
embryos means that foetal tissue transplantation is no longer in favour, but the creation of human
embryos specifically as sources of stem
cells, and the push to use «spare»
embryos from IVF treatments is gatheringmomentum.
Altering DNA in germline
cells —
embryos, eggs, and sperm, or
cells that give rise to them — may be used to cure genetic diseases for future generations, provided it is done only to
correct disease or disability, not to enhance people's health or abilities, a report issued February 14 by the National Academies of Sciences and Medicine recommends.
Then a team of Chinese researchers used that base editor to
correct a mutation in human
embryos that causes the blood disorder beta - thalassemia, reported September 23 in Protein &
Cell (SN: 11/25/17, p. 7).
Researchers from Duke University had previously used CRISPR to
correct genetic mutations in cultured
cells from Duchenne patients, and other labs had
corrected genes in single -
cell embryos in a laboratory environment.
They used colored fluorescent tags to identify the groups in question in
embryos, allowing the
correct cells to be harvested.
The tool has been used to make mutations or
correct them in animals and in human
cells, including human
embryos (SN: 10/14/17, p. 8).
This
cell death bore the hallmarks of apoptosis, a controlled
cell suicide that is needed for the normal development of an
embryo, and to ensure that our immune system contains the
correct array of
cells.
The study, funded by the Pancreatic Cancer Research Fund, examined the role of Hedgehog, whose usual job is to send signals to
cells in
embryos to divide and grow into the
correct body parts.
Experiments with mouse
embryo support
cells that express mutant DUB or pseudo-DUB proteins show an impaired immune response when infected with a virus and impaired DNA damage repair when exposed to ionizing radiation, further validating the need for complex's
correct structure.
In one of the experiments, for example, activation of a particular signal at the
correct time elicits the appearance of the mesoderm, endoderm and ectoderm — the precursors of all
cell types — with a spatial organization similar to that of an
embryo.
Researchers at the University of Cambridge have managed to reconstruct the early stage of mammalian development using embryonic stem
cells, showing that a critical mass of
cells — not too few, but not too many — is needed for the
cells to being self - organising into the
correct structure for an
embryo to form.