CAMBRIDGE, Mass. — Whitehead Institute scientists have identified conserved, long intervening non-coding RNAs (lincRNAs) that play key roles during
embryonic brain development in zebrafish.
Veronica Palma, from University of Chile, led the study with Rehen and highlights the combined approaches allowed the creation of an environment that mimics the one during
embryonic brain development.
The research produced another important finding: «We were able to explain the role of iodine in
embryonic brain development at the cellular level,» says Denise Stenzel.
«BPA and BPS (substitute for BPA) affect
embryonic brain development in zebrafish: Low levels of chemicals linked to hyperactivity.»
Not exact matches
Embryonic stem cells are produced during
development by the same process of epigenetic programming that later will produce adult cells such as skin and
brain.
The latest findings show that genetic defects in the body's ability to manufacture carnitine might be associated with an increased risk of autism because carnitine deficiency interferes with the normal processes by which neural stem cells promote and organize
embryonic and fetal
brain development.
For years, Scripps neuroscientist Jerold Chun had been studying the
embryonic brain and how certain lipids in the blood of both the mother and the embryo affect its
development.
Using a nuclear protein expressed in follicle stem cells (FSCs), the researchers found that castor, which plays an important role in specifying which types of
brain cells are produced during
embryonic development, also helps maintain FSCs throughout the life of the animal.
These include a family of signaling molecules called protocaderins, which regulate neuronal
development and short - range interactions between neurons, and a family of transcription factors called zinc fingers, which are mainly expressed in
embryonic and nervous tissues and are thought to play roles in
brain development.
If these mutations happen during
embryonic development, there could be several neurological problems: the child could become autistic, kids could be born with seizure disorder, or the developing neurons might not migrate to their proper site in the
brain.
Neurocutaneous disorders are caused by abnormal
development of cells in the
embryonic stage, leading to tumors in various parts of the body, including the skin, organs, bones,
brain and spinal cord.
Clues to Urbilateria's
brain plan come from studying the
embryonic development of creatures alive today.
The method could also help biologists understand how tissues change subtly during
embryonic development — and even help map the maze of neurons that wire the human
brain.
This molecule pours out of
embryonic cranial cells after infection with Zika virus, and could harm
brain development.
What we do know is that in mice (and so, presumably, in humans) FOXP2 is active in the
brain during
embryonic development.
The next step, he says, is to investigate how
embryonic mouse
brains with induced folds develop as they mature past the fetal stages of
development and to look across species to see if the gene has similar effects in other mammals.
Researchers have found that a protein critical to the
embryonic development of limbs also plays a role in determining how the mammalian neocortex, the outer layer of the
brain, is formed.
The dynamin - related GTPase Drp1 is required for
embryonic and
brain development in mice.
Interneuron cell - based therapy in AD and related models: During
brain development,
embryonic interneuron precursors are generated in the medial ganglionic eminence (MGE) and retain a remarkable capacity for migration and integration in adult host
brains, where they fully mature into functional inhibitory interneurons.
Intracellular uptake of macromolecules by
brain lymphatic endothelial cells during
embryonic development Stefan Schulte - Merker, Westfälische Wilhelms - Universität Münster
Pasco Rakic has deciphered how neurons in the
embryonic brain arrange themselves during
development into the highly ordered, densely interconnected, and immensely complex circuitry of the adult cerebral cortex.
Mouse
brain tissue from three different stages of the mouse
brain development;
embryonic day 15, postnatal day 2 and postnatal day 21, was studied.
We have shown that the presence of extra centrosomes in proliferating
embryonic neural stem cells is sufficient to impair
brain development and culminates in microcephaly (small
brains) at birth.
The challenge takes on even more urgency with recent
developments, including a federal administration now more open to exploring the potential of stem cells, the recent FDA approval of a human trial involving
embryonic stem cells, as well as the reported case of a young boy who developed a
brain tumor four years after receiving a stem - cell treatment for a rare genetic disorder.
Human
embryonic stem cells grown at the University of Wisconsin - Madison randomly changed into cell types found in the A) gut B)
brain C) bone marrow D) cartilage E) muscle F) kidney Scientists haven't learned to control the
development.
We show that DONSON is expressed in progenitor cells of
embryonic human
brain and other proliferating tissues, is co-expressed with components of the DNA replication machinery, and that Donson is essential for early
embryonic development in mice as well, suggesting an essential conserved role for DONSON in the cell cycle.
It shows a mouse at
embryonic day 10.5 and the expression of the Fezf2 gene in the developing cortical vesicles (in blue) at the start of
brain development.