Sentences with phrase «embryonic cell lineage»

Lead author found guilty of misconduct in embryonic cell lineage paper called into question over a year ago

They have a high chance of being transmitted to offspring as de novo germline mutations and, in principle, can provide insights into early human embryonic cell lineages and their contributions to adult tissues.

Not exact matches

All the muscles of our faces develop from a strip of cells at the base of the embryonic head, just as they do in lampreys, which belong to one of the oldest lineages of vertebrates alive today.

This is a video of rotating view of neural precursor cell tracks obtained from the cell lineage reconstruction of early Drosophila embryonic nervous system development.

Directed and step-wised differentiation of embryonic stem cells toward neuronal, cardiac and pancreatic lineages

When transplanted to the subretinal space of mice lacking functional photoreceptors, human embryonic stem cells directed toward a retinal lineage integrate into the outer nuclear layer, express photoreceptor markers, and restore a light response as determined by the electroretinogram (ERG)[5].

A whole network of these proteins is involved in giving embryonic stem (ES) cells pluripotency — the ability to generate all the cell lineages of the body.

His thesis was entitled «Quantitative description of microRNA target site occupancy in mouse embryonic stem cells and derived cells of neuronal lineage.»

seek to identify the mutational processes underlying mutational signatures found in cancers, characterise the mutational processes operating in normal cells, use phylogenetic analyses of somatic mutations in humans to explore cellular lineages during embryonic development

Embryonic stem cells, Adult stem cells, Reprogramming to pluripotency and lineage conversion, Directed differentiation, Germ cells, Genetic and epigenetic mechanisms, Stem cells in development, Stem cell niche, Cancer stem cells, Disease modeling and drug screening, Stem cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics, Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Journal

The reason is that embryonic stem cells naturally want to make neuroectoderm, a cell lineage in the embryo that forms the nervous system.

Embryonic stem (ES) cells are karyotypically normal, embryo - derived cell lines that are pluripotent, i.e. capable of generating all the cell types of the future organism, but not the extra-embryonic lineages.

However, cells derived from the early epiblast are only able to contribute to embryonic lineages and not those derived from the PrEn [18]--[20], while PrEn cells can only contribute to their own lineage by colonizing the visceral and mostly parietal endoderm in chimera experiments [20]--[22].

While ES cells are derived from the ICM, they predominantly contribute to embryonic lineages.

Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and the germline but are excluded from the extra-embryonic tissues that are derived from the trophectoderm and the primitive endoderm upon reintroduction to the blastocyst.

Citation: Hough SR, Laslett AL, Grimmond SB, Kolle G, Pera MF (2009) A Continuum of Cell States Spans Pluripotency and Lineage Commitment in Human Embryonic Stem Cells.

Commitment in embryonic stem cells is often depicted as a binary choice between alternate cell states, pluripotency and specification to a particular germ layer or extraembryonic lineage.

During that time, she applied her knowledge of the processes governing normal heart development to direct the differentiation of embryonic stem cells into the cardiac lineage.

Execution of pluripotency requires progression from the naïve status represented by mouse embryonic stem cells (ESCs) to a state capacitated for lineage specification.

Lineage commitment in the mammalian embryo is most often depicted as a series of binary choices between alternate cell states, and increasing evidence supports the hypothesis that fate decisions in embryonic stem (ES) cell cultures reflect these developmental processes [1].

We used the mutations to reconstruct developmental lineages of adult cells and demonstrate that the two daughter cells of many early embryonic cell - doubling events contribute asymmetrically to adult blood at an approximately 2:1 ratio.