However, in 2007 Professor Wilmut announced that he had decided to change to an alternative method of research pioneered in Japan, known as direct reprogramming or «de-differentiation», which could create human
embryonic cells without using human eggs or cloning human embryos.
Not exact matches
A few weeks ago we all heard the announcement of a major scientific breakthrough that allowed scientists to create the equivalent of human
embryonic stem
cells (called induced pluripotent stem
cells) but
without using or destroying embryos.
For most in the scientific community, the debate was never truly about whether adult stem
cells or
embryonic stem
cells would be the most useful therapeutically or whether we could obtain
embryonic - like stem
cells without destroying embryos.
Just before Thanksgiving, news broke about a new stem -
cell technique that could produce the equivalent of
embryonic stem
cells (ESCs) but
without using or destroying human embryos.
A pluripotent state makes the resulting
cells indistinguishable from
embryonic stem
cells, and the scientists got these
cells without creating or destroying any embryos.
A type of «virgin birth» stem
cell could be as powerful as
embryonic stem
cells but
without the same ethical objections, and are being tested for Parkinson ’s
Repeated transfection of two expression plasmids, one containing the complementary DNAs (cDNAs) of Oct3 / 4, Sox2, and Klf4 and the other containing the c - Myc cDNA, into mouse
embryonic fibroblasts resulted in iPS
cells without evidence of plasmid integration, which produced teratomas when transplanted into mice and contributed to adult chimeras.
For the first time, specialised
cells have been reprogrammed into the equivalent of
embryonic stem
cells without using genes that might trigger cancer.
But the factor that may make the discovery very significant is that umbilical cord blood can be saved, stored and multiplied
without any of the ethical dilemmas facing
embryonic stem
cell use, which are derived from human fetuses.
The stem
cells, derived from human umbilical cord - blood and coaxed into an
embryonic - like state, were grown
without the conventional use of viruses, which can mutate genes and initiate cancers, according to the scientists.
In an advance touted as a way around current political logjams, scientists have said they can derive human
embryonic stem (ES)
cell lines
without destroying an embryo.
On the other hand, the problem is, you know, with
embryonic stem
cells, they haven't been able to get stem
cell lines from livestock animals that can proliferate in that way,
without just sort of veering up in their own direction and turning into, instead of muscle, turning into brain tissue or bone tissue or something else.
In the past few months, researchers in the United States and Japan have described a promising way of deriving
embryonic stem
cells from skin
cells (of mice)
without destroying embryos — the «Holy Grail of biotechnology,» as The Times of London put it.
These
cells reportedly possessed many of the same characteristics of
embryonic stem
cells,
without requiring the ethically problematic destruction of embryos.
The drawing depicted a stunningly unexpected way to create
embryonic stem
cells —
without using or needing an unfertilized egg.
Others trumpeted «alternative» techniques that promise the creation of
embryonic stem
cells without destroying embryos.
Imagine researchers» excitement, then, when Kyoto University's Shinya Yamanaka reported last year that his group had created embryolike
cells directly,
without transferring chromosomes, simply by injecting mouse fibroblast
cells with four genes that are active in
embryonic cells but not in adult ones.
In vitro experiments used human colon carcinoma
cells with and
without MMP9 and mouse
embryonic fibroblasts, which are connective tissue
cells that make the extracellular matrix and collagen and play an important role in tissue repair.
All the potential of
embryonic stem
cells might be harnessed with the new techniques —
without the political and moral controversy associated with destroying a fertilized egg.
It is possible to force human skin
cells to turn back into
embryonic stem
cells in the lab, but this doesn't seem to be something we are able to achieve
without intervention.
From an entire organ to a dose of
embryonic stem
cells, if the tissue's DNA came from anyone else, the transplant would be rejected
without the aid of harsh immunosuppressive drugs.
She says she sees companies as the entities that translate the discoveries made in academic labs into the solutions that, in Tengion's case, could solve the donor - organ shortage by allowing patients to regenerate their own organs
without using
embryonic stem
cells.
One week after a breakthrough finding, scientists report they can reprogram human skin
cells to behave like
embryonic stem
cells without a growth factor known to cause cancer
The 2012 platform also repeats previous calls for expanding federal funding «for the stem -
cell research that now offers the greatest hope for many afflictions — with adult stem
cells, umbilical cord blood, and
cells reprogrammed into pluripotent stem
cells —
without the destruction of
embryonic human life.»
Other researchers had successfully used a similar process to turn skin
cells into
embryonic - like
cells called induced pluripotent stem
cells, and then grow those iPS
cells into nerve
cells, but Wernig's lab was the first to convert skin
cells directly into nerve
cells without the intermediate iPS
cell step.
One team in Japan, and another in the US, have independently shown it is possible to produce
embryonic - like stem
cells directly from a patient's own skin
cells without having to create and destroy a cloned human embryo first.
Vowing to veto the legislation, Bush said before the vote that the «reports give us added hope that we may one day enjoy the potential benefits of
embryonic stem
cells without destroying human life.»
• In March, a University of Wisconsin team reprogrammed skin fibroblasts into
embryonic stem
cells without incorporating the viral or other foreign DNA that can lead to complications like cancer.
Tumors
without that gene became much less differentiated and more similar to
embryonic cells.
Prescinding from the ethical questions, my own view is that there are scientifically interesting things that can come of
embryonic stem -
cell research, but that even
without regulation, it wouldn't be central.
The researchers suggest that since the adult muscle stem
cells are only activated when injury occurs (by trauma or exercise), they use a new set of genes from those used during
embryonic development, which proceeds
without injury.
Two months ago, several scientists in Wisconsin and Japan announced that they had successfully created a type of stem
cell from ordinary human skin
cells that seems to be able to function exactly like an
embryonic stem
cell without the need to create or destroy human embryos.
Opponents of
embryonic stem
cell research (ESCR) sought a method of producing pluripotent
cells without destroying embryos.
Bush sought to honor the spirit, if not, perhaps, the letter, of Dickey - Wicker by providing funding for
embryonic stem -
cell research
without incentivizing further embryo destruction.
Human
Embryonic Stem
Cell - Derived Cardiomyocytes Can Be Maintained in Defined Medium
Without Serum.
Most recently, Dr. Jaenisch and his colleagues have shown that it is possible to isolate
embryonic stem
cells without harming an embryo through a process known as «altered nuclear transfer.»
One of his early achievements came from his demonstration that techniques used in preimplantation genetic diagnosis could be used to generate human
embryonic stem
cells (hESCs)
without embryonic destruction.
In recent years, researchers have tried to find ways to obtain
embryonic stem
cells without destroying the embryos.
«The holy grail in this field,» Kass says, «is to get
cells which are every bit as capable as
embryonic stem
cells without using embryos at all.»
Before reprogramming can be applied to our own species to generate custom
embryonic stem
cells, scientists must be able to accomplish it
without altering the DNA of the
cells involved.
«However, this study shows now that it's possible to create
embryonic stem
cells without destroying the embryo, and thus
without destroying its potential for life.»
He developed a way to harvest the
embryonic stem
cells without destroying the embryos.
Without these two technologies that you'll hear about in a moment, there would be no such thing as human embryonic stem cell research, and President Bush could have enjoyed his summer vacation in Crawford without having to agonize over the baptism of the infamous 64 stem cell
Without these two technologies that you'll hear about in a moment, there would be no such thing as human
embryonic stem
cell research, and President Bush could have enjoyed his summer vacation in Crawford
without having to agonize over the baptism of the infamous 64 stem cell
without having to agonize over the baptism of the infamous 64 stem
cell lines.