«Just as deletion of the Sox2 gene causes the very early embryo to die, it is likely that an abnormality in the regulatory region would also cause
early embryonic death before any of the organs have even formed,» said Mitchell.
Female -
Biased Embryonic Death from DNA Replication Stress - Induced Inflammation Presented by Adrian McNairn, PhD Postdoctoral Associate - Schimenti Laboratory Department of Biomedical Sciences Cornell University Ithaca, NY
Scientists have known for 20 years that SMN is necessary in every cell of the body, since disrupting the gene in a mouse causes
early embryonic death, before muscle or nerve cells form.
The majority of losses are due to
embryonic death, a failure during the implantation process, or the development of a defective placenta.
But the cross between P. campbelli male x P. sungorus female result in overgrowth, leading to
embryonic death.