Sentences with phrase «embryonic development by»

It is based on the definitive books of mouse embryonic development by Theiler (1989) and Kaufman (1992) yet extends these studies by creating a series of three dimensional computer models of mouse embryos at successive stages of development with defined anatomical domains linked by a stage - by - stage ontology of anatomical names.

The scientists rescued the microcephaly during mouse embryonic development by removing a protein that caused the loss of stem cells.

Not exact matches

While the entity generated by deleting or disabling early embryonic genes would produce only an unorganized collection of stem cells, it would do so after a period of what appears to be relatively normal development.

Embryonic stem cells are produced during development by the same process of epigenetic programming that later will produce adult cells such as skin and brain.

It is possible that in embryonic development similar sorts of ordering are at least initiated by chemical gradients (see LEC).

Other sexual characteristics depend on hormones secreted by the testes or ovaries later in embryonic development.

The latest findings show that genetic defects in the body's ability to manufacture carnitine might be associated with an increased risk of autism because carnitine deficiency interferes with the normal processes by which neural stem cells promote and organize embryonic and fetal brain development.

By observing how the genes changed during the course of embryonic development, scientists could track the emergence of a novel physical trait, the first step toward the creation of a new species.

Some of the researchers at the centre will study the differentiation of stem cells into other cell types, one group by using human embryonic stem cell biology and another by studying early embryo development.

Study shows memories formed by the same gene - silencing tool used in embryonic development; a finding could set the stage for new therapies for schizophrenia

Heller's team produced the inner - ear hair cells by exposing embryonic cells in the lab to chemical factors which steer the natural development of hair cells.

Animals such as salamanders and planaria regenerate tissues by rekindling genetic mechanisms that guide the patterning of body structures during embryonic development.

When examined under a microscope, the tumors resemble immature embryonic kidneys, leading doctors to conclude that Wilms tumors form when kidney development, normally complete by birth, persists into childhood.

Newcastle University and the NorthEast England Stem Cell Institute are aware that the research paper «Derivation of Human Sperm from Embryonic Stem Cells» by a group led by Professor Karim Nayernia has been withdrawn from the academic journal Stem Cells and Development.

According to a report published online today by the journal Nature, mutations in genes that guide embryonic development allowed insects to develop a radically different body plan from that of their crustacean - like ancestors some 400 million years ago.

Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.

Last December, for instance, Chien's group reported finding markers for heart muscle stem cells by tracing their development from embryonic tissue.

Neurocutaneous disorders are caused by abnormal development of cells in the embryonic stage, leading to tumors in various parts of the body, including the skin, organs, bones, brain and spinal cord.

In the meantime, Boeke says Sleeping Beauty could provide a new and better way to create mutants to study embryonic development, since the inactivated gene can be «tagged» using a short DNA sequence inserted by the transposon.

This process is mediated by biological molecules called growth factors, which are proteins that occur naturally in our cells and guide processes ranging from embryonic development to healing.

This technology was pioneered by Shinya Yamanaka, who showed that the introduction of four specific proteins that are essential during early embryonic development could be used to convert adult cells into pluripotent cells.

«For several years, we have been studying myogenesis, a process by which muscles are formed during embryonic development,» says Jean - François Côté, PhD, Director of the Cytoskeletal Organization and Cell Migration research unit at the IRCM.

This discovery by the scientists at the CRG provides an insight into stem cell - forming molecular mechanisms, and is therefore of great interest for studies on the early stages of life, during embryonic development.

The fossils preserve stages of embryonic development frozen in time by miraculous processes of fossilisation, which turned their squishy cells into stone.

This, the team says, can be explained by the embryonic development of the bat's wing, which originates from both the forelimb and the torso.

Early embryonic development of vertebrates is controlled by the genes and their «grammar.»

Su - chun Zhang and his colleagues at the University of Wisconsin, Madison, and the University of Bonn, Germany, directed the development of embryonic stem cells stage by stage, using the same growth factors the body uses.

Tooth development is the complex process by which teeth form from embryonic cells, grow, and erupt into the mouth.

Animals as varied as grasshoppers and mice build their bodies by assembling repetitive pieces during embryonic development.

Details of an organism's embryonic development often reveal traits carried by its evolutionary ancestors; consider, for instance, how human embryos initially develop gill - like slits and a tail.

They accomplished this by using mouse embryonic stem cells to manipulate the mouse genome at the very start of development.

Very soon after fertilization, the control of embryonic development shifts from pre-existing maternal gene products to the products of genes encoded by the early embryo (or zygote).

The researchers hope that these assays will be used by many laboratories that are studying the events associated with early embryonic development and the effect of repeat length and methylation status on gene expression and differentiation.

Embryonic development in mammals begins with the division of the fertilized egg, which is then followed by several further rounds of division to form the blastocyst, a sphere of cells made up of two layers of cells surrounding a fluid - filled cavity.

This migration may happen because the repair pathways initiated by the damaged cells are similar to pathways triggered during embryonic development, where stem cells are key, explains ReNeuron co-founder and chief scientific officer John Sinden.

Although we agree that greater investments are needed in the clinical development of these therapies, we disagree with the authors» suggestion that, relative to embryonic stem cells, adult stem cells provide a superior vehicle for cell - based therapies because they lack tumorigenic activity, can be prepared by methods approved by the Food and Drug Administration (FDA), and have been free of ethical controversy.

The researchers suggest that since the adult muscle stem cells are only activated when injury occurs (by trauma or exercise), they use a new set of genes from those used during embryonic development, which proceeds without injury.

Intracellular uptake of macromolecules by brain lymphatic endothelial cells during embryonic development Stefan Schulte - Merker, Westfälische Wilhelms - Universität Münster

By the late 1800s, researchers understood cancer enough to realize that they must better understand normal development in order to better combat cancerous tumors and their embryonic - like cells (Brewer et al., 2009).

Professor Martinez - Arias and colleagues, supported by the European Research Council and the Wellcome Trust, have reconstructed these early stages of development using mouse embryonic stem cells.

The aorta - gonad - mesonephros (AGM) region in the aortic wall appears to be the most important source of new blood cells, and it has been found to contain numerous hematopoietic stem cells by day 11 of mouse embryonic development.

Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors.

LifeMap Discovery ® is a compendium of embryonic development for stem cell research and regenerative medicine, constructed by integrating extensive molecular, cellular, anatomical and medical data curated from scientific literature and high - throughput data sources.

Since the in vitro reprogramming systems are characterised by very low efficiency Petra's lab focuses on the systems where epigenetic reprogramming occurs naturally as a part of normal embryonic development.

Most Alkbh1 deficient mice die during embryonic development, and survivors are characterized by defects in tissues originating from the ectodermal lineage.

For those species, the human cells could be added at a later stage of embryonic development and would require an extra layer of scrutiny by a special NIH committee.

A number of lines of evidence indicate that in a cancer context, like in development (Daxx - null genotype is an embryonic lethal condition in which the embryos die by age E9.5 [15], due to global apoptosis), DAXX may have a pro-survival role.

10/10/2007 Researchers Reveal Repressor Protein Blocks Neural Stem Cell Development A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons, according to a study by University of California, San Diego and Howard Hughes Me... More...

Created in 2005 through a collaboration between Inserm — National Institute of Health and Medical Research — and AFM - Telethon — French Association against Myopathies — I - Stem is the largest French laboratory for research and development dedicated to human pluripotent stem cells, of embryonic origin or obtained by reprogramming gene.

These images show human embryonic stem cell colonies, as grown in 1998 by researchers at the University of Wisconsin — Madison, in different stages of development.