«The onset of cancer is often through reactivation of
embryonic development pathways that are otherwise dormant,» he says.
Not exact matches
Further investigation, says Resar, showed that these unusual properties arise from the ability of HMGA1 to turn on several genes involved in the Wnt
pathway, a network of proteins necessary for
embryonic development and stem cell activity.
They were interested in one of the cell's key signaling
pathways, the MAPK
pathway, which helps control cell growth,
embryonic development, and the maturation of oocytes into eggs.
The ERK
pathway plays a critical role in
embryonic development and tissue repair because it instructs cells to multiply and start dividing, but when over activated cancer growth occurs.
These experimental systems allow scientists to dissect key molecular
pathways that specify cell fate decisions in
embryonic development,» said team leader Lin He, a UC Berkeley associate professor of molecular and cell biology.
As described in the journal Genes &
Development, the researchers identified a new
pathway controlling heterochromatin organisation in mouse
embryonic stem cells.
This migration may happen because the repair
pathways initiated by the damaged cells are similar to
pathways triggered during
embryonic development, where stem cells are key, explains ReNeuron co-founder and chief scientific officer John Sinden.
Caspary's lab studies the Hedgehog
pathway in early
embryonic development.
The Secretory
Pathway Calcium ATPase PMR - 1 / SPCA1 Has Essential Roles in Cell Migration during Caenorhabditis elegans
Embryonic Development.
This signaling
pathway was found to be important in
embryonic bone
development (Wan et al., 2013), and in osteoblasts (bone cells) regulation (Glass et al., 2005; Harada & Rodan, 2003).
The researchers also identified new links between aggressive meningioma proliferation and activation of an intercellular signaling
pathway called Wnt — which typically plays a role during
embryonic development and tissue formation.
La Jolla, CA — Scientists at the Salk Institute have discovered a novel genetic
pathway that ensures body organs develop correctly and in the right position during
embryonic development.
Now researchers at the Salk Institute for Biological Studies have identified an essential cellular
pathway in zebrafish that paves the way for limb regeneration by unlocking gene expression patterns last seen during
embryonic development.