These genes normally guide
embryonic heart development; however, in the adult mice hearts, they helped transform non-beating cells that form scar tissue into beating heart muscle cells.
Since the signalling mechanisms affected in these diseases are the same mechanisms that occur during
embryonic heart development, their study is a subject of great interest and relevance.
Not exact matches
Last December, for instance, Chien's group reported finding markers for
heart muscle stem cells by tracing their
development from
embryonic tissue.
«Discovery of a gene that could convert human
embryonic stem cells into myocardial cells would be golden,» said Didier Stainier, PhD, UCSF assistant professor of biochemistry and biophysics, the senior author of the UCSF study and a pioneer in the study of
heart development in the transparent zebrafish embryo.
In his postdoctoral training at Metrohealth Medical Center, Duke University Medical Center, and Mt. Sinai Medical Center, he has been interested in the maintenance of electrical function in the
heart during
embryonic development and in
heart failure models.
5/15/2008 New Role Found for a Cardiac Progenitor Population In a discovery that could one day lead to an understanding of how to regenerate damaged
heart tissue, researchers at the University of California, San Diego have found that parent cells involved in
embryonic development of the epicardium — the cell l...
They found that groups of genes appear to work together in
heart cells in a coordinated fashion — switching on and off as a group at designated times during
embryonic development.
In a similar manner, the induction of hematopoietic (cluster 20, day 3.5 +4 = E7.5) and cardiovascular - specific (cluster 12, 3.5 +5 = E8.5) genes follows the chronological order of the appearance of blood islands and the formation of the
heart tube during
embryonic development [50], [51].
During that time, she applied her knowledge of the processes governing normal
heart development to direct the differentiation of
embryonic stem cells into the cardiac lineage.
For example, plasticizing chemicals like BPA and BPS disrupt
embryonic development and are linked to
heart disease and cancer.
On rare occasions ectopic thyroid tissue (abnormal migration of thyroid tissue during
embryonic development) can give rise to lesions in the tongue, ventral neck, cranial mediastinum and
heart base.