Sentences with phrase «embryonic lethality»
"Embryonic lethality" refers to a condition where an embryo, which is the early stage of development of a living organism, cannot survive and dies before birth or hatching. Full definition
If the abnormal phenotype is due solely to KD of htt, then supplementing KD mice with human htt should rescue these deficits as suggested by prior work showing that human htt rescues embryonic lethality in htt KO mice (Hodgson et al., 1996 and 1999).
psychogenics.com
However, the protein is ubiquitous and expressed in the developing embryo where it plays an essential role as revealed by the early embryonic lethality at day 7.5 of the complete knockout of the huntingtin gene in mouse.
However, unlike B -LRB--) / B -LRB--) mice, 15 B (a *) / B (a *) mice of 172 F2 generation mice survived embryonic lethality but developed a dilated cardiomyopathy as adults.
When they compared the results to the Mouse Genomic Informatics Knockout database they found 123 genes that corresponded with functional annotation of abnormal extra-embryonic tissue morphology, 121 associated with embryonic lethality, and 14 with abnormal embryo implantation.
Errors in chromosome segregation are a major cause for birth defects and embryonic lethality in humans, and the most common genetic alteration in human tumors is aberrant chromosome numbers, called aneuploidy.
Targeted deletion of fatty acid transport protein - 4 results in early embryonic lethality.
They recapitulate natural selection and evolution: in complex gene networks, mutations or deletions of highly linked (hub) genes lead to embryonic lethality, while mutations of weakly linked genes account for biological variability and natural selection (Oikonomou and Cluzel, 2006).
When they compared the results to the Mouse Genomic Informatics Knockout database they found 123 genes that corresponded with functional annotation of abnormal extraembryonic tissue morphology, 121 associated with embryonic lethality, and 14 with abnormal embryo implantation.
In ADAR1 - null embryos, the lack of formation of the Dicer - ADAR1 complex results in dysregulated expression of many genes involved in cell death, cell proliferation, and organogenesis, which is likely to contribute at least in part to their embryonic lethality.
Consistent with these results, genetic inactivation of an HR gene (Fancd2) and Polq in mice results in embryonic lethality.
Errors in chromosome segregation can cause birth defects and embryonic lethality in humans and cause aneuploidy, the most common genetic alteration in tumors.