The next step, he says, is to investigate how
embryonic mouse brains with induced folds develop as they mature past the fetal stages of development and to look across species to see if the gene has similar effects in other mammals.
Not exact matches
So Harkany and his colleagues cultured
mouse embryonic brain cells that expressed cannabinoid receptor proteins (CBRs) and exposed them to gradients of synthetic cannabinoids.
When they transplanted
embryonic brain cells into
mice that had already been conditioned to fear a sound, the researchers found these
mice were significantly more responsive to extinction training.
Other
mice had implants of dead
embryonic brain cells for comparison.
Yong - Chun Yu at Fudan University in Shanghai, China, and his team wondered if fearful adult
mice could be helped by a transplant of
embryonic brain cells.
McKay announced that he had mitigated the symptoms of Parkinson's in rats by using
mouse embryonic stem cells that he had turned into dopamine - producing
brain cells.
What we do know is that in
mice (and so, presumably, in humans) FOXP2 is active in the
brain during
embryonic development.
Now, a new paper suggests that
mouse embryonic stem cells can indeed accomplish this feat and lead to a partial recovery for animals with
brain damage akin to Parkinson's.
The team injected about 2000
mouse embryonic stem cells each into the
brains of 25 rats who had previously had their dopamine - producing neurons damaged, which causes a characteristic tendency to move in circles.
Mouse embryonic stem cells injected into rat
brains express the AHD2 protein marker (yellow) characteristic of cells lost in Parkinson's disease.
When the FGF8 gene was injected into or removed from the front part of the
brains of
embryonic mice, structures toward the front became elongated or foreshortened, respectively.
The dynamin - related GTPase Drp1 is required for
embryonic and
brain development in
mice.
Mouse brain tissue from three different stages of the mouse brain development; embryonic day 15, postnatal day 2 and postnatal day 21, was stu
Mouse brain tissue from three different stages of the
mouse brain development; embryonic day 15, postnatal day 2 and postnatal day 21, was stu
mouse brain development;
embryonic day 15, postnatal day 2 and postnatal day 21, was studied.
We show that DONSON is expressed in progenitor cells of
embryonic human
brain and other proliferating tissues, is co-expressed with components of the DNA replication machinery, and that Donson is essential for early
embryonic development in
mice as well, suggesting an essential conserved role for DONSON in the cell cycle.
Transplantation of neural cells derived from retinoic acid - treated cynomolgus monkey
embryonic stem cells successfully improved motor function of hemiplegic
mice with experimental
brain injury.
Mihail Sarov (Max Planck Institute, Germany): CRISPR / Cas9 - induced disruption of gene expression in
mouse embryonic brain
It shows a
mouse at
embryonic day 10.5 and the expression of the Fezf2 gene in the developing cortical vesicles (in blue) at the start of
brain development.