A much - watched clinical trial on
embryonic stem cell therapy for spinal cord injuries was dropped by Menlo Park biotech Geron in 2011.
A clinical trial in the Republic of Korea for patients with degenerative eye diseases is the first to test the safety of
an embryonic stem cell therapy for people of Asian descent.
Advanced Cell Technology, based in Santa Monica California, is developing
embryonic stem cell therapies for macular degeneration and other conditions using cells obtained non-destructively from an early embryo called a blastocyst.
Not exact matches
The truth, of course, is that there are no human
embryonic stem -
cell therapies even in clinical trial, let alone ready
for therapy, and there have been no major treatment....
(In many ways it is worse than when John Edwards said in 2004 that if people voted
for John Kerry, people like Christopher Reeve would get out of their wheelchairs and walk from
embryonic stem cell therapies.)
In the past year, the South Korean Food and Drug Administration (FDA) has approved the world's first three
stem -
cell treatments — Hearticellgram - AMI, Cupistem and Cartistem — which followed on the heels of clinical tests
for human
embryonic stem -
cell therapies approved in 2010, according to the health ministry.
The immediate payoff was a commercialization deal in age - related macular degeneration in which Pfizer became the first big pharma company to make a move into the use of
embryonic stem cells as the basis
for a tissue regeneration
therapy.
Finding may enhance understanding of human
embryonic stem cells and lead to better models
for regenerative
therapies
The study, which followed four individuals
for a year after they were treated with
embryonic stem cell - derived retinal pigment epithelial
cells for macular degeneration, observed no serious side effects (tumor growth or other unexpected effects) related to the
therapy.
Because the precise activation of Hox genes is essential
for a
cell's fate, «the research should prove extremely useful in developing novel
embryonic stem cell - based
therapies, Mazzoni adds.
The world's first chimeric monkeys were created in a laboratory last year, and they offer surprising new insights into
embryonic stem cell therapy: One reason
for often - poor treatment outcomes may be that we're using embryos that are, strangely, just too old.
A fix
for broken rat hearts Scientists this week successfully implanted human
embryonic stem cells into rats that suffered heart attacks, coming a heartbeat closer to realizing the full potential of such
therapy.
For these
cells to be as useful as
embryonic stem cells, «we have to find a way to avoid retroviruses before application in
cell therapy», Yamanaka says, as they could result in tumours.
In a bid to counteract some of the hype, scientists came to Rockefeller University here last week
for a 1 - day conference that offered a clear - eyed look at obstacles that will have to be surmounted before human
embryonic stem (ES)
cells can be used in
therapy.
It is not known how long it will take
for embryonic stem cells to become a useful
therapy or whether they will ever directly do so.
After hearing a brief explanation that laid out the different sources of
stem cells (but left undiscussed their current uses or future potential
for therapy), the respondents offered a slightly more nuanced set of views, and only a slight majority (52 %) supported
embryonic stem cell research.
Although we agree that greater investments are needed in the clinical development of these
therapies, we disagree with the authors» suggestion that, relative to
embryonic stem cells, adult
stem cells provide a superior vehicle
for cell - based
therapies because they lack tumorigenic activity, can be prepared by methods approved by the Food and Drug Administration (FDA), and have been free of ethical controversy.
Derivation of pluripotent
stem cells, either of
embryonic origin or following genetic reprogramming, has opened the path
for an alternative source
for epidermal
cell therapy as these
cells are both immortal and pluripotent, theoretically capable of providing any requested number of
cells of any desired phenotype.
For the first time, through the use of human embryonic stem cells (hES) sourced from pre-implantation diagnosis, researchers from Inserm's Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystrop
For the first time, through the use of human
embryonic stem cells (hES) sourced from pre-implantation diagnosis, researchers from Inserm's Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystro
stem cells (hES) sourced from pre-implantation diagnosis, researchers from Inserm's Institute
for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystrop
for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystro
Stem Cell Therapy and Exploration of Monogenic Diseases (I -
Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystro
Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystrophy.
Not so long ago, human
embryonic stem cell (hESC) research and SCNT were being hailed as the future of regenerative medicine, capable of generating cures and
therapies for any number of diseases and conditions.
This information could then be used to prompt
embryonic stem cells to differentiate in the culture dish into neurons
for potential use in
cell - replacement
therapy.
Embryonic cell lines and autologous embryonic stem cells generated through therapeutic cloning have also been proposed as promising candidates for future t
Embryonic cell lines and autologous
embryonic stem cells generated through therapeutic cloning have also been proposed as promising candidates for future t
embryonic stem cells generated through therapeutic cloning have also been proposed as promising candidates
for future
therapies.
Such an immunological exemption could alleviate many concerns about using
cells for therapy that don't exactly match the recipient's immune system - such as existing
embryonic stem cell lines that are not directly derived from the recipient.
This approach to derive patient - specific
Embryonic Stem cell - like
cells (iPS
cells) is going to open up research into the genetic causes of disease and the search
for therapies not only
for such diseases, but also
for repairing tissues damaged in other ways.
In addition, we use our expertise to facilitate the development of functionally mature beta
cells from
embryonic stem cells for cell replacement
therapies of type 1 diabetes.
Virtually identical to human
embryonic stem cells (hESCs) except
for their origin of isolation, the recently created induced pluripotent
stem cells (iPSCs)(Yu et al., 2007; Takahashi et al., 2007) hold much potential
for use in regenerative
therapies.
For only the second time, the Food and Drug Administration approved a company's request to test an
embryonic stem cell - based
therapy on human patients.
The US Food and Drug Administration's linkurl: decision; https://www.the-scientist.com/blog/display/55353/ to green light a human
embryonic stem cell - based
therapy for spinal cord injury isn't just good news
for the biotech in question, Geron Corp., analysts say — instead, they argue, the move opens the door to an entire market that has heretofore been stymied.
YDSTIE: So does this move us any closer to the day when
embryonic stem cells can actually be used
for therapy?
It's no accident,
for instance, that both early studies of
embryonic stem -
cell therapies — those of Geron and Advanced Cell — involved cells of the nervous sys
cell therapies — those of Geron and Advanced
Cell — involved cells of the nervous sys
Cell — involved
cells of the nervous system.
Jaenisch believes they will eventually succeed and points out that the technique could eventually yield a bountiful supply of custom human
embryonic stem cells for use in
therapy.
Lanza's dream of turning human
embryonic stem cells into
therapies for the sick and the suffering is taking a huge step closer to reality.
«If we overcome the other obstacles, this approach could one day provide custom human
embryonic stem cells for use in
therapy.»
Patient - specific
stem cells may offer an alternative to
embryonic stem cells that will skirt the need
for immunosuppressive
therapy as well as the social and political ramifications of
embryonic stem cell research, but their utility extends far beyond such groundbreaking advances and will assist future clinical practice and patient care.
96/3: 45 RNF12 is essential
for X-inactivation in female mouse
embryonic stem cells, is required
for female mouse development, and might be a target
for future
therapies to treat X-linked disorders in females: Evidence from a mouse knockout model.
Late last year the preeminent firm in the field, Silicon Valley's Geron, abdicated its leadership position in the midst of the first - ever FDA - approved clinical trial
for an
embryonic -
stem -
cell therapy.
Professor Elly Tanaka and her research group at the DFG Research Center
for Regenerative
Therapies Dresden — Cluster of Excellence at the TU Dresden (CRTD) demonstrated
for the first time the in vitro growth of a piece of spinal cord in three dimensions from mouse
embryonic stem cells.