The result has been
the emergence of strains of infections including tuberculosis and malaria, pneumonia and gonorrhoea that resist all known classes of drugs.
However,
the emergence of strain Ug99 in Uganda in 1999 devastated crops and has spread to Kenya, Ethiopia, Sudan and Yemen, though has yet to reach the U.S.
The emergence of that strain is a complex story.
Not exact matches
Antibiotics place a selective pressure on a bacterial population, often resulting in the
emergence of resistant
strains.
Such a suggestion is not out
of line either with the logic
of emergence or with the testimony
of significant
strains of religious symbolism.
In February 2004, avian influenza virus was detected in birds in Vietnam, increasing fears
of the
emergence of new variant
strains.
Full - scale production
of a vaccine that could prevent any illness at all from the
strain would require at least three months after the virus's
emergence to begin, but it is hoped that vaccine production could increase until one billion doses were produced by one year after the initial identification
of the virus.
The
emergence of the new H1N1 flu
strain has demonstrated the effectiveness
of existing systems to watch for human flu outbreaks while also proving a long - standing theory that pigs could serve as mixing vessels for a pandemic virus.
Pandemic flu continues to threaten public health, especially in the wake
of the recent
emergence of an H7N9 low pathogenic avian influenza
strain in humans.
Based on a pathogen's evolutionary history, researchers hope to spot the modern
emergence of antibiotic - resistant
strains.
However, genetic resistance in crop varieties is frequently defeated by the
emergence of new rust
strains, turning what used to be a disease resistant plant variety to one that is completely vulnerable.
Next, the investigators constructed a mathematical model to explain how the virus evolves during ART without the
emergence of highly drug - resistant
strains.
Over-the-counter sales
of amantadine in China may have favored the
emergence of resistant
strains, Bright says.
The
emergence of the final
strain is imminent.
Professor De Voss said the scale
of the threat, compounded by the
emergence of increasingly drug - resistant
strains of bacteria, meant it was vital to find new ways to combat tuberculosis.
The new backbone could help streamline annual vaccine production, which could be especially relevant during a pandemic, notes Kawaoka's group, when the sudden
emergence of novel
strains forces companies to rapidly make millions
of doses
of a new vaccine.
«You could have the
emergence of superhot
strains,» as a result, he says.
The findings offer much - needed strategies for monitoring the
emergence of dangerous bird flu
strains capable
of infecting humans and for developing more effective vaccines.
If the treatment, described here this week at the annual meeting
of the American Society for Microbiology, works in humans, it could help prevent the
emergence of resistant
strains of the bacteria.
In the humanized mouse model under the conditions studied here, partial loss
of cxcr4 in human T cells due to treatment with X4 - ZFNs provided selective pressure for either the evolution or
emergence of a pre-existing single amino acid mutation in the V3 loop
of the infecting X4 HIV - 1
strain that enabled it to use CCR5 as efficiently as CXCR4.
«We were able to create, within seven days, the
emergence in the swarm
of an epidemic
strain that took at least several years to occur in nature,» Vignuzzi said.
Recent genomic advances are contributing to our understanding
of the
emergence and spread
of a multidrug - resistant cholera
strain [78], for example, and helping to identify variants that might account for differences in host susceptibility to other waterborne infections such as schistosomiasis [79], [80].
The
emergence of new
strains, and the lack
of cross-protection by existing vaccines, does not leave much time for vaccine development.
Although the morbidity and mortality
of that pandemic were lower than feared, public health professionals continuously monitor for the
emergence of more virulent
strains [61].
A fundamental problem in infectious disease is that pathogens and vectors are continually evolving, such that disease control efforts can eventually lead to
emergence of resistant
strains and rebound
of disease in a less controllable form.
Various studies predict an average 30 percent reduction in farm incomes due to climate change impacts, including greater extremes in temperatures and rainfall (floods, droughts) and the
emergence of new pest and disease
strains.
In the past decade, the rapid spread
of aggressive
strains of yellow rust, and the
emergence and spread
of Ug99, have demonstrated that only combined, international efforts may solve or reduce these serious problems, which are threatening the daily bread supply in many wheat growing areas in Asia and Africa.
«The standard vaccines that are in current use are safe and effective, and not prone to cause the
emergence of more dangerous
strains of viruses.
Another very worrisome development is the
emergence of multi-resistant Neisseria
strains that cause the STD gonorrhoea.
«Continuing global genetic surveillance and investigation will help us to identify the
emergence of further resistant
strains and improve our understanding
of how they arise and spread.»
Such approaches are becoming less effective due to the
emergence of pesticide - resistant mosquito populations and drug - resistant
strains of the parasite.
The scientists were able to characterise distinct genetic patterns or «fingerprints» for each
of the
strains, showing the approach offers a rapid and novel way to detect and track the global
emergence of drug resistance.
Many existing treatments for malaria - one
of the deadliest infectious diseases - target only one stage
of the complex life cycle
of the Plasmodium parasite that causes the disease, and are further limited by the
emergence of drug resistance in particular
strains.
7/16/2007 Researchers Discover Key Mechanism to
Emergence of Deadly Strep Bacteria The incidence
of serious strep infections has risen dramatically in the last three decades, and this increase is largely attributed to the spread around the globe
of a single
strain of strep known as the invasive M1T1 clone.
Due to the
emergence of antibiotic - resistant
strains, the World Health Organization has recently classified H. pylori in group 2 high - priority bacteria for which new treatments are urgently needed.
«Our greatest challenge impacting human health and our eco-systems stems from the ongoing
emergence of new viral
strains and mutants as a consequence
of globalisation, migration and travel.
Antimicrobial treatment
of K. pneumoniae infections has become increasingly difficult as a consequence
of the
emergence and spread
of strains that are resistant to multiple antimicrobials.
A better understanding
of the genomic changes that facilitate the
emergence and spread
of drug resistant M. tuberculosis
strains is required.
Although we are beginning to understand the processes that underlie the evolutionary dynamics
of seasonal influenza viruses, the timing and nature
of emergence of new virus
strains remain mostly unpredictable.
It is widely recognised that the widespread use
of antibiotics has generated selective pressures that have driven the
emergence of resistant
strains.
While anti-malarial drugs exist, the
emergence of drug - resistant parasite
strains remains a global health concern and no vaccine has been licensed to date.
Although high in promastigotes in vitro, aneuploidy dropped significantly in hamster amastigotes, in a progressive and
strain - specific manner, accompanied by the
emergence of new polysomies.
This finding urges further vigilance and improved control measures to limit the dissemination
of this lineage and the
emergence of more C. difficile MDR -
strains.
Klebsiella pneumoniae shows increasing
emergence of multidrug - resistant lineages, including
strains resistant to all available antimicrobial drugs.
If these technologies prolong infectious periods
of hyperpathogenic
strains, as we have shown vaccination can, they too could create conditions favouring the
emergence of highly lethal
strains.
Our data show that anti-disease vaccines that do not prevent transmission can create conditions that promote the
emergence of pathogen
strains that cause more severe disease in unvaccinated hosts.
Annual testing is important even in animals receiving a monthly preventative, because
of the
emergence of new
strains of Heartworms that are resistant to the preventative medications.
In the rural regions
of Southern China where SARS broke out, the people and animals lived in inordinately close contact and there was widespread use
of wild species for food and traditional medicine, along with little testing available to catch new
strains of diseases, the conditions there promoted the
emergence of the virus.
Perhaps it has something to do with the peculiar mixture
of post-68 entropy and diasporic unravelling
of mass political and social movements and the concomitant
emergence of more radically elusive and secretive
strains of resistance, unable or unwilling to be reduced to a defining form or identity.
Antibiotics result in the
emergence of resistant
strains the same way levees create greater flooding downstream.