Sentences with phrase «emerging drug resistance»
Conclusions: Our findings suggest that targeted malaria control will benefit the surrounding community, but unfortunately also that emerging drug resistance will spread rapidly through the population.
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Additional uses include precise diagnosis of microbial infection, describing transmission patterns, understanding the genomics of emerging drug resistance and identifying targets for new therapeutics and vaccines.
Not exact matches
The memorandum of understanding identified four areas in the life sciences where AAAS and the Cuban Academy of Sciences will seek opportunities for sustained cooperation: emerging infectious diseases, brain disorders, cancer, and antimicrobial drug resistance.
Resistance to the drug had not emerged in part because it was typically only used when other drugs had failed.
Globalization, changing climate, and the threat of drug resistance have conspired to set the stage for that perfect microbial storm: a situation in which an emerging pathogen — another HIV or smallpox, perhaps — might burst on the scene and kill millions before we can respond.
PAILIN, CAMBODIA — No one knows exactly why resistance to malaria drugs always emerges first in this remote western province of Cambodia, nestled in the Cardamom Mountains.
The World Health Organization (WHO) released a plan today to deal with a threat that could undermine the recent success in malaria control: the emerging resistance against artemisinin drugs, which are the cornerstone of malaria treatment worldwide.
Over the past few years, researchers have seen resistance against artemisinin derivatives — which are combined with other drugs in so - called artemisinin - based combination therapies — emerge in Cambodia, in an area along the border with Thailand.
«We on the outside of the US are gravely concerned about the drug resistance emerging in the US,» said Peter Davies, a TB researcher at Sefton General Hospital, Liverpool.
This understanding may eventually help us to stem the rise of drug - resistant malaria, such as the emerging resistance to artemisinins,» said Lisewski.
There are signs of emerging resistance even to the latest generation of drugs being rolled out, the highly effective artemisinin - based drugs, triggering worries that the world might soon be left empty - handed (Science, 19 December 2008, p. 1776).
«Understanding how the drugs work gives us the opportunity to investigate new treatments, for example by using combination therapies, or altering the dosage and timing of treatment to prevent drug resistance from emerging,» Dr Glaser said.
New research demonstrates that harnessing competition among pathogens inside a patient could extend the life of existing drugs where resistance is already present and prevent resistance to new drugs from emerging.
Chloroquine has become ineffective against malaria, and resistance to the other frontline drugs is emerging,» says senior author of the study Professor Dominic Kwiatkowski, of the Wellcome Trust Sanger Institute and Oxford University.
In many cases, these successive waves of drug resistance first emerged in the same part of Southeast Asia, the Lower Mekong region, and then spread to other malaria endemic areas.
This is an impressive achievement but these gains are threatened by emerging resistance to the frontline antimalarial drug, artemisinin.
Assist disease control by providing up - to - date geographical information about known and newly - emerging forms of drug resistance, by examining genetic variation in the context of how whole pathogen genomes are evolving rather than as fragmentary information about individual genetic changes or polymorphisms.
As the TRAC study sites were selected to target areas of emerging resistance, samples will include parasites that are artemisinin resistant alongside sensitive parasites — those that are more easily killed off by the drug.
«Encouraged by promising predictions from the mathematical model, we completed a detailed laboratory study using parasites from Cambodia where drug - resistance is emerging,» Professor Tilley said.
Recent spread of artemisinin resistance and emerging piperaquine resistance in Southeast Asia show that artemisinin combination therapy, such as dihydroartemisinin - piperaquine, are losing clinical effectiveness, prompting investigation of drug resistance mechanisms and development of strategies to surmount emerging anti-malarial resistance.
Background: As the prevalence of artemisinin - resistant Plasmodium falciparum malaria increases in the Greater Mekong subregion, emerging resistance to partner drugs in artemisinin combination therapies seriously threatens global efforts to treat and eliminate this disease.
«If a drug is used less, then less resistance emerges,» said Patricia Griffin, chief of intestinal disease epidemiology for the Center for Disease Control.