Sentences with word «emtricitabine»

While it's been facing some sales problems on the former front, the biotech is now attempting to strengthen its position in the latter with solid new data for an HIV treatment cocktail combining bictegravir with emtricitabine / tenofovir alafenamide, two of its main drugs for the virus.

The Federal Court had found that that the object of the invention was to take advantage of the chemically stable characteristics of tenofovir and emtricitabine in combination and sometimes with a third medicinal ingredient.

Their cocktail therapy adding bictegravir to its mainstays emtricitabine / tenofovir alafenamide (200 / 25 mg)(FTC / TAF) proved non-inferior to dolutegravir and other antiretroviral therapies in the 4 late - stage studies, setting up a new drug application in a matter of weeks as Gilead races to a near - term marketing OK.

The uninfected partners randomly received a placebo or a pill that contained a licensed anti-HIV drug: either tenofovir or a combination of tenofovir and emtricitabine known as Truvada.

The work was funded by Liotta's earlier work on HIV drug emtricitabine that resulted in a sale by Emory University to Gilead Sciences.

Randomised placebo - controlled trials have shown that daily oral pre-exposure prophylaxis (PrEP) with tenofovir - emtricitabine reduces the risk of HIV infection.

But it turned out that many physicians didn't feel comfortable giving healthy individuals the heavy - duty drug — a combination of emtricitabine and tenofovir, which are used to treat AIDS.

The researchers said the third group of women — those treated with TDF along with emtricitabine and atazanavir / ritonavir — actually had a 10 percent lower risk of premature birth and other complications than those who didn't receive TDF.

The «475 Patent claimed chemically stable characteristics of tenofovir and emtricitabine in combination and sometimes with a third medicinal ingredient.

Gilead hopes to pair bictegravir with emtricitabine / tenofovir alafenamide, drugs that are considered the «backbone» of HIV treatments.

A combination of two HIV drugs, tenofovir disoproxil fumarate and emtricitabine, sold under the name Truvada, was approved by the Food and Drug Administration for daily use as pre-exposure prophylaxis, or PrEP, in the U.S. in 2012 to help prevent HIV infection.

Angela D. M. Kashuba, Pharm.D., of the University of North Carolina, and colleagues determined what intracellular ratios of active tenofovir and emtricitabine, the drugs that compose Truvada, to the DNA molecules with which they compete are necessary to prevent HIV replication.

The Federal Joint Committee (G - BA) specified two appropriate comparator therapies according to the approval status: Treatment - naive patients, i.e. patients who had not been treated for HIV before, were to receive efavirenz in combination with tenofovir and emtricitabine or in combination with abacavir and lamivudine.

The drug combination of elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil (elvitegravir fixed combination, trade name: Stribild) has been approved in Germany since May 2013 for the treatment of adults infected with human immunodeficiency virus type 1 (HIV - 1).

The only FDA - approved PrEP is Truvada, a combination of two antiretroviral medications used to treat HIV: tenofovir and emtricitabine.

The uninfected partner took a daily tablet of either anti-HIV drug tenofovir, a combination of tenofovir and emtricitabine — another anti-HIV drug — or a placebo.

The two drugs in Truvada, emtricitabine and tenofovir, are effective antiretroviral treatments, but trials have shown that viruses exposed to lower doses in the acute phase of infection can become resistant, said meeting attendees.

PrEP is an HIV prevention strategy in which at - risk HIV - negative people take a daily pill of Truvada, which contains the antiretroviral drugs tenofovir and emtricitabine, to prevent them from becoming infected.

When atazanavir was used with newer drugs, such as tenofovir or emtricitabine, the risk of birth defects remained higher, but there was no significant elevation in risk when atazanavir was used with older ARV drugs like zidovudine or lamivudine.

Participants were randomly assigned (1:1) to receive daily combined tenofovir disoproxil fumarate (245 mg) and emtricitabine (200 mg)(also known as Truvada) either immediately (275 patients) or after a deferral period of 1 year (269 patients).

San Francisco, CA — In a finding with the potential to fundamentally change strategies to slow the global HIV epidemic, a new study called iPrEx shows that individuals at high risk for HIV infection who took a single daily tablet containing two widely used HIV medications, emtricitabine and tenofov

The study found no difference in the risk for premature birth, low birth weight or other serious complications among those who didn't receive TDF and those who got TDF along with emtricitabine and lopinavir / ritonavir.

The NDS stated that the drug, known as Complera, contained the medicinal ingredients: tenofovir, emtricitabine, and rilpivirine.

According to a Make Medicines Affordable (MMA) post, in January 2017, Brazil's National Institute of Industrial Property (INPI) announced that it had rejected the patent application filed by Gilead Sciences back in January 2004, covering the combination of TDF and emtricitabine.

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