Sentences with word «enantiomer»

• Developed five HPLC methods for the separation of enantiomers of bis - phenols, and discovered vanadium catalyzed asymmetric oxidative coupling of phenols.

Asymmetric chemical synthesis is extremely important because it allows chemists to produce new chiral drug candidates, such as single enantiomers of nonnaturally occurring amino acids.

This could open up a whole class of compounds that were previously a major challenge to produce as pure enantiomers.»

Development and Validation of Chiral HPLC Method for Identification and Quantification of (R)- Enantiomer in Ezetimibe

Chemical reactions often generate two substances whose chemical structures behave like image and mirror image, so called enantiomers.

One way of finding the structure of a naturally occurring l protein might therefore be to mix it with its d enantiomer before performing X-ray diffraction analysis.

None of the starting material would be wasted on synthesis of the inactive enantiomer.

Meanwhile, among ester substrates, the esters of chiral amino acids can be successfully reacted, and the purity of the correct enantiomer is safely preserved.

The particles are chiral, with the two enantiomers alternating in the crystal lattice.

The investigators tracked the accumulation of escitalopram in lipid - raft fractions from glioma cells and discovered that escitalopram gradually accumulated in lipid rafts in a concentration and time - dependent manner while its nontherapeutic enantiomer, R - citalopram, did not.

Mr. Justice Boivin's recent application of the sound prediction test to the selection of 1 enantiomer for preventing blood clots aptly illustrates the problem with the sound prediction test.

According to the Federal Circuit decision, the district court's claim construction analysis centered on «what combination of enantiomers claim 14 encompassed.»

[6] Sanofi - Aventis v Apotex, 2013 FCA 186 at para. 134 - 135 (the majority referred to tests «clearly disclosed» in the patent in finding there was a sound prediction of enantiomer clopidogrel's advantages at paras. 53, 71)

The remarkable anti-HIV activity of the racemic mixture necessitated the synthesis of single enantiomers to identify the active isomer.

The product's chirality just depends on the arrangement of these atoms, so if you begin with a pure enantiomer, you retain that purity.

We synthesized a K + channel containing the d - enantiomer of alanine in place of a conserved glycine and found by x-ray crystallography that its filter maintains the K + (conductive) structure in the presence of Na + and very low concentrations of K +.

Many pharmaceuticals are also chiral, and often only one enantiomer has a medicinal use.

Enantiomers can have very different properties.

Although their atoms are connected in exactly the same sequence, the two enantiomers are distinct mirror images, like a pair of hands.

Many chemical compounds display a feature called chirality, where two versions — known as enantiomers — exist for the same molecule.

Whereas most organic chemists take great pains to separate mixtures of enantiomers that they synthesise, there are times when «racemic» mixtures, containing equal quantities of the d and l forms, are desirable.

Further evidence that the products were chiral was that each enantiomer would cleave only a peptide chain of the same chirality and was only inhibited by inhibitors of the same chirality.

Organic molecules in which four different chemical groups are attached to a central carbon atom are also chiral, as they too can be constructed in two forms, usually labelled d and l and known as enantiomers.

This relies on the fact that solutions of pure enantiomers rotate the plane of polarisation of light passing through them; opposite enantiomers rotate it in opposite directions.

Carbon - based compounds can assemble into forms that are mirror images, or enantiomers.

Chiral light - matter interactions have been investigated for two centuries, leading to the discovery of many chiroptical processes used for discrimination of enantiomers.

Mirror - image isomers (enantiomers) can have substantially different biological properties, so the selective synthesis of just one enantiomer is desirable.

Furthermore, since AMD070 and related (S)- enantiomers were previously demonstrated to have a significant increase in potency, representative compounds from the pyridine 142, the thiophene 146 and the furan 149 series were synthesized as the (S)- enantiomers, resulting in compounds with an IC50 value of 4.2, 1.0, and 0.3 nM, respectively.

When derivatives were resolved in single enantiomers, compounds with S - configuration at the chiral center showed higher CXCR4 antagonistic activity with respect to the corresponding R - isomers.

Regarding my particular interests in organic synthesis, we always have to deal with chiral molecules which are present in nature as single enantiomers.

As a result, the S - enantiomer showed to be very active, while the R - enantiomer was markedly less active.

The complex molecules that exist here on our planet often come in two versions, each mirror images or enantiomers of one another.

The majority of naturally occurring (plant and animal) substances for which stereoisomers are possible exist in nature as single enantiomers.

Because only one enantiomer of a pharmaceutical (drug) is likely to be therapeutically active, chemists have devised strategies for preparing chemical compounds of only one enantiomer.

These strategies are: (1) physical separation by temporarily converting the two enantiomers into two diastereomers (called resolution); (2) physical separation in a chiral chromatographic environment; (3) chemical discrimination in a chiral environment (using enzymes or other chiral platforms as chemical reagents); and (4) asymmetric synthesis of one enantiomer in preference to the other.

Because laboratory chemical reactions are not usually conducted in chiral environments, they will produce 1:1 (racemic) mixtures of enantiomers.

S - but not R - enantiomers of flurbiprofen and ibuprofen reduce human microglial and THP - 1 cell neurotoxicity.

Naturally occurring vitamin E is a family of compounds, all members of which are chiral and only one enantiomer of each occurs in nature, so taking alpha - tocopherol doesn't meed the body's need of vitamin E.

Though glucose and fructose are enantiomers, in other words their molecular structures are mirror images of each other and they are completely different and act different too.

Reverse T3 is a kind of chemical opposite of regular T3, a mirror image compound called an enantiomer.

The district court did not err in construing claim 14 to cover the -LRB----RRB-- enantiomer.

In the Minister's view, a previously approved medicinal ingredient (here an enantiomer) could never be an «innovative drug» regardless of the innovator's effort in developing the...