Not exact matches
When similar analysis was performed on the db mice, it was found that the disrupted db gene was responsible for
encoding a protein that functions as a leptin
receptor: When it binds circulating leptin at the
cell surface, it sets in motion a biochemical cascade inside the
cell.
One key gene
encodes the making of a
receptor called TREM2, a docking site for molecules on the
surface of microglia and other innate immune
cells.
Without it, NFAT initiates a negative regulatory program that activates genes
encoding inhibitory
cell surfaces markers and blunts signals received by the T
cell receptor.
At the heart of the pathway lies the daf - 2 gene, which
encodes a member of the insulin family of
cell surface receptors.