The cellular functions that Finch studied for his «second Ph.D.» included the activation of the gene that
encodes tyrosine aminotransferase (TAT).
The complementary DNA that
encoded the tyrosine phosphatase replaced the mitotic activator p80cdc25, closely associating the cdc25 (+)- activating pathway with tyrosine dephosphorylation of pp34.
The NTRK fusions involved a gene segment
encoding a tyrosine kinase domain.
Not exact matches
The sequence, called an ITAM (immunoreceptor
tyrosine - based activation motif),
encodes a piece of protein that can by itself signal immune system cells to multiply and go to work.
These therapies, the first an antibody and the second of a class called
tyrosine kinase inhibitors (TKIs), reduce the ability of a target gene to manufacture the protein it
encodes.
AXL
encodes a receptor
tyrosine kinase that promotes breast cancer bone metastasis in mouse models (41).
Further, we identified a role for ABL kinases in promoting the expression of multiple pro — bone metastasis genes such as AXL (which
encodes a receptor
tyrosine kinase), IL6 (which
encodes interleukin - 6), MMP1 (which
encodes matrix metalloproteinase 1), and TNC (which
encodes tenascin - C) through TAZ - and signal transducer and activator of transcription 5 (STAT5)-- mediated signaling.