Sentences with phrase «encoding cell receptors»

Not exact matches

When similar analysis was performed on the db mice, it was found that the disrupted db gene was responsible for encoding a protein that functions as a leptin receptor: When it binds circulating leptin at the cell surface, it sets in motion a biochemical cascade inside the cell.

One key gene encodes the making of a receptor called TREM2, a docking site for molecules on the surface of microglia and other innate immune cells.

Down syndrome is caused by having three copies of chromosome 21 instead of two, and since four of the six interferon receptors — the proteins that sense the presence of interferons — are encoded on chromosome 21, cells with trisomy 21 react more strongly to small amounts of interferons in their microenvironment.

The researchers scoured the already deciphered mouse genome, looking for genes that might encode additional receptor proteins in its olfactory system, the sensory cells that connect the nose to the brain.

Functional glutamate receptor (GluRs) were transiently expressed in cultured mammalian cells from cloned complementary DNAs encoding GluR - A, - B, - C, or - D polypeptides.

June's team also wants to knock out two gene segments that encode different portions of the protein that makes up a T cell's primary receptor so that the engineered NS - ESO - 1 receptor will be more effective.

Under normal circumstances, people whose taste receptor cells make more messenger RNA (mRNA) for a given gene make more of the encoded receptor.

Without it, NFAT initiates a negative regulatory program that activates genes encoding inhibitory cell surfaces markers and blunts signals received by the T cell receptor.

Dr. Mak is an internationally acclaimed immunologist renowned for his 1984 cloning of the genes encoding the human T - cell receptor.

At the heart of the pathway lies the daf - 2 gene, which encodes a member of the insulin family of cell surface receptors.

We have tested this hypothesis by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N - methyl - d - aspartate (NMDA) receptor NR1, specifically in dentate gyrus granule cells.

The new gene encodes a receptor that, on one end, can bind to a molecule that's unique to cancerous B cells.

The researchers used the new technique to mutate the genes CXCR4 and CCR5, which encode receptor molecules that different strains of the HIV virus use to sneak in and infect immune cells and which have been targeted in previous cell therapy trials.

Two other Wnt target genes, RNF43 and ZNRF3, encode stem cell - specific E3 ligases that downregulate Wnt receptors.

Among the receptors, expression of mRNA of genes that encode for NTRK2, NGFRAP1, ESR1 and EDNRA was higher in cumulus cells, while oocytes had significantly higher expression of mRNA of genes that encode for IGF1R, ESR2 and TGF - βR3.

BACKGROUND Homozygous loss - of - function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of

Polymorphisms in five of 15 genes (33 %) encoding molecules known to primarily influence pancreatic beta - cell function - ABCC8 (sulphonylurea receptor), KCNJ11 (KIR6.2), SLC2A2 (GLUT2), HNF4A (HNF4alpha), and INS (insulin)- significantly altered disease risk, and in three genes, the risk allele, haplotype, or both had a biologically consistent effect on a relevant physiological trait in the QT study.