So what we think is that probably in many cells in this section, all cells, the chromatin is
encountered in a specific state, and in order to render the cell is permissive to reprogramming, you have to overcome these certain epigenetic modifications that block, for example, the binding of Ascl1 to its target chains, or the binding of other transcription factors to its target chains, then this way interfere with the possibility of reprogramming.
Not exact matches
When we think about, for example, what the
state of unemployment is
in the US or the extent to which the average American
encounters crime, one relevant source of information is this perception of society as a whole: If one's impression is that America as a whole is doing badly, then one would infer that the situation for a
specific issue would be rather negative as well.
To complicate matters, over the course of the 20th century,
states began using time - based measures — called instructional, clock, or contact hours —
in a number of other
state policy areas, such as minimum requirements for educational programs, school approval standards, and formulas for distributing
state funding.11 Moreover, depending on the
specific school design and the particular
state context, high school innovators can
encounter a wide range of other friction points.