Sentences with phrase «endocannabinoid signaling»

The lower Body Mass Index (BMI) of pot - smokers may be explained by an adaptive down - regulation of brain endocannabinoid signaling.

Jan Mulder, Tania Aguado, Erik Keimpema, Klaudia Barabás, Carlos J. Ballester Rosado, Laurent Nguyen, Krisztina Monory, Giovanni Marsicano, Vincenzo Di Marzo, Yasmin L. Hurd, Francois Guillemo, Ken Mackie, Beat Lutz, Manuel Guzman, Hui - Chen Lu, Ismael Galve - Roperh, Tibor Harkany (2008) «Endocannabinoid signaling controls pyramidal cell specification and corticothalamic axon patterning», Proc Natl Acad Sci U S A, 105:8760 - 8765.

We are particularly interested in an emotional stress - induced change in endocannabinoid signaling and synaptic transmission and the effects of stress on the activity of a neuronal circuitthat is associated with learning / memory (see J. Neurosci.31: 501, 2011, 29:381, 2009; Nature Neurosci.

Corollary studies focused on the mechanisms that regulate brain endocannabinoid signaling have provided critical in vivo evidence of an «on demand,» activity - dependent nature of endocannabinoid influence.

Current studies in the Parsons laboratory are investigating whether binge patterns of drug consumption evoke similar endocannabinoid disruptions, and they are probing the influence of impaired endocannabinoid signaling in the excessive motivational effects produced by drug - associated conditioned cues.

Dr. Parsons has shown that while there is some degree of tonic endocannabinoid formation in the brain, an overt influence of endocannabinoid signaling requires synapse - specific activation of endocannabinoid formation.

Distinct neurobiological mechanisms are thought to contribute to these stages of the addiction cycle, and Dr. Parsons made the seminal discovery that repeated intermittent drug exposure dysregulates endocannabinoid signaling in a manner that contributes to excessive and compulsive forms of drug consumption.

Current research addresses how disrupted endocannabinoid signaling during brain development primes for delayed neuropsychiatric illness.

He explained that rimonabant, a drug which blocked endocannabinoid signaling at cannabinoid receptors, was on the market in Europe for the treatment of human obesity.

The work describes for the first time that overeating associated with chronic consumption of a western diet is driven by an enhancement in endocannabinoid signals generated in peripheral organs.

Not exact matches

It is comprised of lipid signaling molecules called endocannabinoids — which can be thought of as the body's own «natural cannabis» — that bind to cannabinoid receptors located on cells throughout the body.

The psychoactive compound in marijuana, THC, is similar to some of the body's own signaling molecules, called endocannabinoids.

The natural endocannabinoid system regulates anxiety and the response to stress by dampening excitatory signals that involve the neurotransmitter glutamate.

Using a combination of behavioral techniques, pharmacological manipulations, and in vivo microdialysis, he also demonstrated that endocannabinoids influence drug reward through the CB1 receptor - mediated modulation of dopamine, GABA, and glutamate signaling in the mesocorticolimbic and striatopallidal circuits.

An example will be taken from the discovery of the role of CNS endocannabinoids in neuronal signaling that may lead to the development of better anxiolityc drugs.

Endocannabinoids are important endogenous signaling molecules in our body and the endocannabinoid system is thought to be one of the body's natural defense systems against injury.

He developed an innovative microdialysis approach that allows the in vivo sampling of lipid signaling molecules in the brain (including endocannabinoids) and has demonstrated that voluntary self - administration of ethanol, heroin, and cocaine produces distinct drug - and region - specific changes in brain endocannabinoid levels.

Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors) in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals, epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast cells as effector cells in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast cells, the allergic effector unit, mast cell derived tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast cell activation in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels

Once activated, the endocannabinoid system's cannabinoid receptors control the passage of proteins between cells, sending out signals for your pet's body to make the necessary adjustments to get any function that has become unbalanced back to the level where it should be.